Rare Disease Trial Updates: August 2026
In August 2026, Trial Friend tracked 575 rare disease clinical trial updates across 104 conditions, including 5 FDA-related actions and 84 trial status changes, alongside enrollment updates and new trial site openings sourced from ClinicalTrials.gov and FDA announcements.
This is a permanent monthly archive. For the latest updates, see the live current events feed.
Major Updates: FDA Actions, Status Changes & Results
No longer enrolling new participants
No longer enrolling new participants
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No longer enrolling new participants
No longer enrolling new participants
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Now recruiting (was Active Not Recruiting)
The U.S. Food and Drug Administration today approved Mimrylo (rusfertide), a new treatment for adults with polycythemia vera, a rare blood disorder that causes the body to make too many red blood cells.
The U.S. Food and Drug Administration has approved Lisraya (brepocitinib) tablets for the treatment of dermatomyositis in adults.
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
The FDA granted orphan drug designation to immune globulin intravenous (human), developed by Kedrion S.p.A, on 2026-08-25 for the treatment of stiff person syndrome. Orphan designation is an incentive for rare disease drug development, not an approval: it gives the sponsor tax credits, fee waivers, and 7 years of market exclusivity if the drug is eventually approved. It often signals that a company is committing to a full development program.
No longer enrolling new participants
The FDA granted orphan drug designation to ambroxol, developed by LILA Holding AG, on 2026-08-24 for the treatment of Gaucher disease. Orphan designation is an incentive for rare disease drug development, not an approval: it gives the sponsor tax credits, fee waivers, and 7 years of market exclusivity if the drug is eventually approved. It often signals that a company is committing to a full development program.
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
Status changed from Recruiting to Enrolling By Invitation
No longer enrolling new participants
Now recruiting (was Active Not Recruiting)
No longer enrolling new participants
Now recruiting (was Enrolling By Invitation)
No longer enrolling new participants
No longer enrolling new participants
Now recruiting (was Active Not Recruiting)
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
Now recruiting (was Active Not Recruiting)
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
Status changed from Recruiting to Enrolling By Invitation
No longer enrolling new participants
No longer enrolling new participants
The FDA approved Orzeyful (oveporexton) tablets for the treatment of narcolepsy type 1 in adults.
Status changed from Recruiting to Enrolling By Invitation
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
Now recruiting (was Active Not Recruiting)
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
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No longer enrolling new participants
Trial Site & Enrollment Activity
Added 1 new site: Hamilton, Canada
Added 1 new site: Seoul, South Korea
Added 1 new site: Chongqing, China
Added 7 new sites: Coronado, California, Englewood, Colorado, Littleton, Colorado and 4 more
Added 3 new sites: Jupiter, Florida, Houston, Texas, Kocaeli, Turkey (Türkiye)
Reduced from 40 to 38 sites
Target enrollment increased from 260 to 333
Added 3 new sites: Baltimore, Maryland, Morrisville, North Carolina, Florence, Italy
Added 4 new sites: Tainan, Taiwan, Ankara, Turkey (Türkiye), Ankara, Turkey (Türkiye) and 1 more
Added 3 new sites: Graz, Austria, Innsbruck, Austria, Leipzig, Germany
Added 4 new sites: Peoria, Illinois, Norton Shores, Michigan, Tulsa, Oklahoma and 1 more
Added 1 new site: Charlottesville, Virginia
Added 5 new sites: Milwaukee, Wisconsin, Toronto, Canada, Montreal, Canada and 2 more
Eligibility criteria have been updated
Added 1 new site: Liège, Belgium
Added 4 new sites: Tainan, Taiwan, Ankara, Turkey (Türkiye), Ankara, Turkey (Türkiye) and 1 more
Added 2 new sites: Gilbert, Arizona, Durham, North Carolina
Reduced from 8 to 6 sites
Added 1 new site: Ottawa, Canada
Added 3 new sites: Peoria, Illinois, Houston, Texas, San Juan, Puerto Rico
Added 2 new sites: Copenhagen, Denmark, Odense C, Denmark
Added 2 new sites: Boca Raton, Florida, Houston, Texas
Added 2 new sites: Tampa, Florida, Kansas City, Kansas
Added 5 new sites: Scottsdale, Arizona, O'Fallon, Illinois, Greenfield, Wisconsin and 2 more
Added 1 new site: Joinville, Brazil
Eligibility criteria have been updated
Added 3 new sites: Cordova, Tennessee, Tallinn, Estonia, Poznan, Poland
Eligibility criteria have been updated
Added 6 new sites: Sofia, Bulgaria, Tbilisi, Georgia, Niš, Serbia and 3 more
Target enrollment decreased from 55 to 25
Added 1 new site: Shanghai, China
Eligibility criteria have been updated
Added 1 new site: Reno, Nevada
Added 1 new site: Songpa-dong, South Korea
Added 43 new sites: Birmingham, Alabama, Kissimmee, Florida, Ann Arbor, Michigan and 40 more
Added 4 new sites: Seattle, Washington, Buenos Aires, Argentina, Buenos Aires, Argentina and 1 more
Added 8 new sites: Los Angeles, California, Las Vegas, Nevada, Reno, Nevada and 5 more
Added 4 new sites: Chicago, Illinois, Minneota, Minnesota, Greenville, North Carolina and 1 more
Added 2 new sites: Cambridge, United Kingdom, London, United Kingdom
Added 1 new site: Houston, Texas
Added 6 new sites: Torrance, California, Morehead City, North Carolina, DeSoto, Texas and 3 more
Added 3 new sites: Bergamo, Italy, Rome, Italy, Madrid, Spain
Added 60 new sites: Linz, Austria, Vienna, Austria, Vienna, Austria and 57 more
Eligibility criteria have been updated
Added 1 new site: Beachwood, Ohio
Eligibility criteria have been updated
Eligibility criteria have been updated
Added 4 new sites: Tainan, Taiwan, Ankara, Turkey (Türkiye), Ankara, Turkey (Türkiye) and 1 more
Eligibility criteria have been updated
Added 1 new site: Liège, Belgium
Added 3 new sites: Frisco, Texas, Mendoza, Argentina, Gurugram, India
Added 16 new sites: Ann Arbor, Michigan, St Louis, Missouri, Bron, France and 13 more
Reduced from 48 to 44 sites
Added 6 new sites: Philadelphia, Pennsylvania, Brasília, Brazil, Porto Alegre, Brazil and 3 more
Added 6 new sites: New York, New York, Beaumont, Texas, Schwäbisch Hall, Germany and 3 more
Added 7 new sites: Philadelphia, Pennsylvania, Philadelphia, Pennsylvania, São Paulo, Brazil and 4 more
Eligibility criteria have been updated
Target enrollment increased from 52 to 65
Reduced from 130 to 120 sites
Added 1 new site: Knoxville, Tennessee
Eligibility criteria have been updated
Added 1 new site: Liège, Belgium
Added 2 new sites: Matosinhos Municipality, Portugal, Barcelona, Spain
Added 1 new site: Nottingham, United Kingdom
Added 1 new site: Krakow, Poland
Added 6 new sites: Hokkaido, Japan, Tokyo, Japan, Glasgow, United Kingdom and 3 more
Added 2 new sites: Miami, Florida, Cincinnati, Ohio
Added 4 new sites: Baltimore, Maryland, Houston, Texas, Montreal, Canada and 1 more
Added 1 new site: Norwich, United Kingdom
Reduced from 28 to 23 sites
Added 1 new site: Tokyo, Japan
Added 4 new sites: Montpellier, France, Düsseldorf, Germany, Trieste, Italy and 1 more
Eligibility criteria have been updated
Added 12 new sites: Al Jahra, Kuwait, Andalusia, Kuwait, Kuwait City, Kuwait and 9 more
Added 1 new site: Salt Lake City, Utah
Target enrollment increased from 58 to 78
Eligibility criteria have been updated
Eligibility criteria have been updated
Added 10 new sites: The Woodlands, Texas, Burgas, Bulgaria, Angers, France and 7 more
Reduced from 30 to 20 sites
Eligibility criteria have been updated
Added 2 new sites: Chicago, Illinois, Philadelphia, Pennsylvania
Target enrollment decreased from 94 to 31
Moved from Phase 2 to Phase 2, Phase 3
Target enrollment increased from 28 to 168
Eligibility criteria have been updated
Added 2 new sites: Birmingham, Alabama, Chicago, Illinois
Target enrollment increased from 3 to 4
Added 1 new site: Houston, Texas
Added 3 new sites: São Paulo, Brazil, Munich, Germany, Kfar Saba, Israel
Added 2 new sites: Boston, Massachusetts, Toledo, Spain
Added 1 new site: Okayama, Japan
Added 7 new sites: Palo Alto, California, San Diego, California, Boston, Massachusetts and 4 more
Added 2 new sites: Shenyang, China, Tianjin, China
Eligibility criteria have been updated
Added 1 new site: Salt Lake City, Utah
Added 18 new sites: New Haven, Connecticut, Atlanta, Georgia, CABA, Argentina and 15 more
Added 2 new sites: Grand Rapids, Michigan, West Perth, Australia
Added 4 new sites: Oakland, California, Palo Alto, California, Lexington, Kentucky and 1 more
Added 2 new sites: George Town, Malaysia, Kuantan, Malaysia
Added 4 new sites: Montpellier, France, Düsseldorf, Germany, Trieste, Italy and 1 more
Added 12 new sites: Brandon, Florida, Miami, Florida, Atlanta, Georgia and 9 more
Added 1 new site: Nijmegen, Netherlands
Added 1 new site: Leuven, Belgium
Added 18 new sites: New Haven, Connecticut, Atlanta, Georgia, CABA, Argentina and 15 more
Target enrollment decreased from 37 to 29
Added 6 new sites: Hot Springs, Arkansas, Bethesda, Maryland, Hackensack, New Jersey and 3 more
Eligibility criteria have been updated
Added 4 new sites: Orange, California, Tampa, Florida, Chapel Hill, North Carolina and 1 more
Added 1 new site: Lebanon, New Hampshire
Reduced from 179 to 177 sites
Added 3 new sites: Göttingen, Germany, Würzburg, Germany, Hanamaki, Japan
Added 1 new site: Amherst, New York
Added 2 new sites: Farmington Hills, Michigan, New Bern, North Carolina
Added 3 new sites: Göttingen, Germany, Würzburg, Germany, Hanamaki, Japan
Eligibility criteria have been updated
Added 6 new sites: Santiago del Estero, Argentina, Zagreb, Croatia, Dublin, Ireland and 3 more
Reduced from 11 to 1 sites
Eligibility criteria have been updated
Added 5 new sites: Camperdown, Australia, Mannheim, Germany, Essen, Germany and 2 more
Added 4 new sites: Zagreb, Croatia, Bydgoszcz, Poland, Poznan, Poland and 1 more
Added 1 new site: Bydgoszcz, Poland
Added 2 new sites: Philadelphia, Pennsylvania, Lewisville, Texas
Added 8 new sites: Zagreb, Croatia, Vukovar, Croatia, Chiba, Japan and 5 more
Added 3 new sites: Atlanta, Georgia, Atlanta, Georgia, Cincinnati, Ohio
Eligibility criteria have been updated
Target enrollment increased from 60 to 120
Eligibility criteria have been updated
Added 7 new sites: São Paulo, Brazil, Vancouver, Canada, Shenzhen, China and 4 more
Eligibility criteria have been updated
Added 1 new site: Taipei, Taiwan
Added 4 new sites: New Haven, Connecticut, Boston, Massachusetts, Boston, Massachusetts and 1 more
Added 33 new sites: Orlando, Florida, Beijing, China, Beijing, China and 30 more
Added 1 new site: Houston, Texas
Added 5 new sites: Concord, Australia, Anyang-si, South Korea, Seongnam-si, South Korea and 2 more
Added 2 new sites: Hong Kong, China, Hong Kong, China
Added 5 new sites: Iowa City, Iowa, Gosford, Australia, Monterrey, Mexico and 2 more
Reduced from 111 to 104 sites
Added 4 new sites: Mar del Plata, Argentina, Quilmes, Argentina, Québec, Canada and 1 more
Added 4 new sites: Englewood, Colorado, São Paulo, Brazil, Santiago, Chile and 1 more
Added 1 new site: Palo Alto, California
Eligibility criteria have been updated
Added 1 new site: Rochester, Minnesota
Added 5 new sites: Surrey, Canada, Kawasaki, Japan, Kitakyushu, Japan and 2 more
Added 2 new sites: Los Angeles, California, Asheville, North Carolina
Added 2 new sites: Shanghai, China, Kuching, Malaysia
Added 5 new sites: Miami, Florida, Tampa, Florida, Columbus, Ohio and 2 more
Added 5 new sites: Miami, Florida, Tampa, Florida, Columbus, Ohio and 2 more
Added 1 new site: St Louis, Missouri
Added 1 new site: Kirchheim unter Teck, Germany
Eligibility criteria have been updated
Added 8 new sites: Poway, California, Boston, Massachusetts, St Louis, Missouri and 5 more
Reduced from 9 to 5 sites
Target enrollment decreased from 15 to 8
Added 1 new site: New York, New York
Added 5 new sites: Olympia Fields, Illinois, Dallas, Texas, San Miguel de Tucumán, Argentina and 2 more
Added 1 new site: Birmingham, Alabama
Target enrollment decreased from 48 to 32
Added 16 new sites: New Haven, Connecticut, Atlanta, Georgia, CABA, Argentina and 13 more
Target enrollment decreased from 24 to 6
Added 1 new site: Seattle, Washington
Eligibility criteria have been updated
Added 1 new site: Leuven, Belgium
Added 3 new sites: Stony Brook, New York, Cincinnati, Ohio, Columbus, Ohio
Added 1 new site: Palo Alto, California
Eligibility criteria have been updated
Target enrollment increased from 300 to 3000
Added 1 new site: Spokane, Washington
Target enrollment decreased from 192 to 128
Added 7 new sites: Buenos Aires, Argentina, Monza, Italy, Salerno, Italy and 4 more
Added 2 new sites: Newport Beach, California, Montreal, Canada
Eligibility criteria have been updated
Added 1 new site: Duarte, California
Eligibility criteria have been updated
Added 3 new sites: Stony Brook, New York, Cincinnati, Ohio, Columbus, Ohio
Added 4 new sites: Baltimore, Maryland, Houston, Texas, Montreal, Canada and 1 more
Added 4 new sites: Baltimore, Maryland, Guiyang, China, Jinan, China and 1 more
Eligibility criteria have been updated
Target enrollment increased from 4000 to 5000
Added 1 new site: Leuven, Belgium
Added 1 new site: Toronto, Canada
Eligibility criteria have been updated
Added 10 new sites: Laguna Hills, California, Chicago, Illinois, Edegem, Belgium and 7 more
Added 7 new sites: Nashville, Tennessee, Vancouver, Canada, Heidelberg, Germany and 4 more
Added 2 new sites: Paris, France, London, United Kingdom
Added 4 new sites: Randwick, Australia, Porto Alegre, Brazil, Sai Paula, Brazil and 1 more
Added 34 new sites: Mobile, Alabama, Hartford, Connecticut, Plantation, Florida and 31 more
Eligibility criteria have been updated
Added 8 new sites: Athens, Greece, Pátrai, Greece, Thessaloniki, Greece and 5 more
Added 5 new sites: Miami, Florida, Tampa, Florida, Columbus, Ohio and 2 more
Moved from Phase 1, Phase 2 to Phase 3
Expanded from 105 to 106 sites
Added 5 new sites: Miami, Florida, Tampa, Florida, Columbus, Ohio and 2 more
Added 1 new site: Berlin, Germany
Expanded from 105 to 106 sites
Added 2 new sites: Amsterdam, Netherlands, Al Ahsa, Saudi Arabia
Target enrollment increased from 10 to 120
Added 7 new sites: Atlanta, Georgia, Chicago, Illinois, St Louis, Missouri and 4 more
Added 5 new sites: Miami, Florida, Tampa, Florida, Columbus, Ohio and 2 more
Added 1 new site: St Louis, Missouri
Added 1 new site: Skawina, Poland
Added 11 new sites: Chicago, Illinois, Leuven, Belgium, Helsinki, Finland and 8 more
Target enrollment increased from 5000 to 10000
Target enrollment decreased from 60 to 20
Added 4 new sites: Belo Horizonte, Brazil, Lille, France, Mexico City, Mexico and 1 more
Added 4 new sites: Houston, Texas, Foggia, Italy, Rome, Italy and 1 more
Eligibility criteria have been updated
Added 6 new sites: New York, New York, Prague, Czechia, Villejuif, France and 3 more
Added 23 new sites: Phoenix, Arizona, Los Angeles, California, Sacramento, California and 20 more
Eligibility criteria have been updated
Added 2 new sites: Los Angeles, California, Saint Albans, Australia
Target enrollment increased from 62 to 78
Eligibility criteria have been updated
Added 10 new sites: Antwerp, Belgium, Bordeaux, France, Lyon, France and 7 more
Eligibility criteria have been updated
Added 2 new sites: Birmingham, Alabama, Ann Arbor, Michigan
Added 4 new sites: Glendale, California, Lexington, Massachusetts, Cincinnati, Ohio and 1 more
Target enrollment increased from 8 to 27
Added 2 new sites: Wilmington, Delaware, Seattle, Washington
Moved from Phase 1, Phase 2 to Phase 1
Added 2 new sites: Orlando, Florida, Atlanta, Georgia
Added 35 new sites: Liverpool, Australia, Birtinya, Australia, Herston, Australia and 32 more
Eligibility criteria have been updated
Added 1 new site: Cerqueira César, Brazil
Added 3 new sites: Madrid, Spain, Seville, Spain, Newcastle, United Kingdom
Added 8 new sites: Los Angeles, California, Edegem, Belgium, Garches, France and 5 more
Added 2 new sites: St Louis, Missouri, Richmond, Virginia
Added 2 new sites: Los Angeles, California, Saint Albans, Australia
Added 71 new sites: Los Angeles, California, Washington D.C., District of Columbia, Kansas City, Kansas and 68 more
Target enrollment increased from 62 to 78
Eligibility criteria have been updated
Added 2 new sites: Los Angeles, California, Saint Albans, Australia
Added 1 new site: Tampa, Florida
Target enrollment increased from 40 to 59
Eligibility criteria have been updated
Added 5 new sites: Rome, Italy, Rome, Italy, Kragujevac, Serbia and 2 more
Target enrollment increased from 12 to 24
Added 2 new sites: Lodz, Poland, Yenimahalle, Turkey (Türkiye)
Added 2 new sites: Newport Beach, California, Montreal, Canada
Eligibility criteria have been updated
Reduced from 125 to 116 sites
Target enrollment increased from 50 to 60
Eligibility criteria have been updated
Reduced from 65 to 63 sites
Eligibility criteria have been updated
Added 4 new sites: Milan, Italy, Foggia, Italy, Roma, Italy and 1 more
Added 7 new sites: Torrance, California, Choceň, Czechia, Kaunas, Lithuania and 4 more
Added 1 new site: Salford, United Kingdom
Added 2 new sites: Newport Beach, California, Montreal, Canada
Added 7 new sites: Hollywood, Florida, Miami, Florida, Chicago, Illinois and 4 more
Target enrollment increased from 60 to 151
Added 1 new site: Lyon, France
Eligibility criteria have been updated
Added 1 new site: Munich, Germany
Added 1 new site: München, Germany
Eligibility criteria have been updated
Added 4 new sites: Evanston, Illinois, Rochester, Minnesota, Omaha, Nebraska and 1 more
Target enrollment increased from 450 to 750
Eligibility criteria have been updated
Added 3 new sites: Recife, Brazil, Natal, Brazil, Prague, Czechia
Reduced from 204 to 178 sites
Added 4 new sites: San Luis, Argentina, Greenslopes, Australia, Montreal, Canada and 1 more
Added 1 new site: Rotterdam, Netherlands
Added 6 new sites: Los Angeles, California, Temple, Texas, Camperdown, Australia and 3 more
Added 21 new sites: Camperdown, Australia, Westmead, Australia, Vancouver, Canada and 18 more
Eligibility criteria have been updated
Added 3 new sites: Detroit, Michigan, Philadelphia, Pennsylvania, Colchester, Vermont
Added 1 new site: Haifa, Israel
Target enrollment decreased from 81 to 62
Added 13 new sites: Sacramento, California, Farmington, Connecticut, Durham, North Carolina and 10 more
Added 5 new sites: Chicago, Illinois, New York, New York, Morrisville, North Carolina and 2 more
Target enrollment increased from 32 to 39
Eligibility criteria have been updated
Added 4 new sites: Madera, California, Jacksonville, Florida, Orlando, Florida and 1 more
Eligibility criteria have been updated
Target enrollment decreased from 39 to 8
Added 1 new site: Sacramento, California
Added 7 new sites: Lyon, France, Paris, France, Tours, France and 4 more
Added 32 new sites: Salt Lake City, Utah, Maruípe, Brazil, Edmonton, Canada and 29 more
Added 32 new sites: Salt Lake City, Utah, Maruípe, Brazil, Edmonton, Canada and 29 more
Added 2 new sites: Thessaloniki, Greece, Torino, Italy
Added 4 new sites: Houston, Texas, Tbilisi, Georgia, Tbilisi, Georgia and 1 more
Eligibility criteria have been updated
Eligibility criteria have been updated
Added 1 new site: Waltham, Massachusetts
Reduced from 15 to 12 sites
Added 1 new site: Erie, Pennsylvania
Target enrollment decreased from 9 to 3
Added 1 new site: Philadelphia, Pennsylvania
Eligibility criteria have been updated
Added 2 new sites: Hialeah, Florida, Worcester, Massachusetts
Reduced from 152 to 150 sites
Added 3 new sites: Atlanta, Georgia, Boise, Idaho, Cleveland, Ohio
Reduced from 54 to 35 sites
Eligibility criteria have been updated
Target enrollment increased from 5000 to 10000
Target enrollment increased from 5000 to 10000
Added 2 new sites: Los Angeles, California, Saint Albans, Australia
Target enrollment increased from 62 to 78
Eligibility criteria have been updated
Eligibility criteria have been updated
Added 1 new site: Cincinnati, Ohio
Eligibility criteria have been updated
Added 1 new site: Toronto, Canada
Eligibility criteria have been updated
Added 16 new sites: Buenos Aires, Argentina, Córdoba, Argentina, Córdoba, Argentina and 13 more
Eligibility criteria have been updated
Target enrollment decreased from 88 to 4
Added 3 new sites: Madrid, Spain, Seville, Spain, Newcastle, United Kingdom
Added 34 new sites: Little Rock, Arkansas, San Francisco, California, Bethesda, Maryland and 31 more
Target enrollment decreased from 160 to 104
Eligibility criteria have been updated
Added 2 new sites: Ann Arbor, Michigan, Columbus, Ohio
Eligibility criteria have been updated
Target enrollment decreased from 5000 to 756
Added 8 new sites: Aurora, Colorado, Philadelphia, Pennsylvania, Ribeirão Preto, Brazil and 5 more
Added 1 new site: Talcahuano, Chile
Added 3 new sites: New York, New York, São Paulo, Brazil, Lisbon, Portugal
Target enrollment decreased from 140 to 109
Target enrollment decreased from 420 to 139
Added 3 new sites: Hamburg, Germany, Oldenburg, Germany, Regensburg, Germany
Eligibility criteria have been updated
Added 1 new site: Leeds, United Kingdom
Added 3 new sites: Madrid, Spain, Seville, Spain, Newcastle, United Kingdom
Added 3 new sites: Munich, Germany, Halle, Germany, München, Germany
Target enrollment increased from 5000 to 10000
Added 2 new sites: Hanover, Germany, Ulm, Germany
Moved from Phase 2 to Phase 2, Phase 3
Eligibility criteria have been updated
Eligibility criteria have been updated
Added 1 new site: London, United Kingdom
Added 2 new sites: Wilmington, Delaware, Seattle, Washington
Eligibility criteria have been updated
Reduced from 127 to 114 sites
Reduced from 8 to 6 sites
Added 1 new site: Jacksonville, Florida
Added 7 new sites: Cambridge, United Kingdom, London, United Kingdom, Oxford, United Kingdom and 4 more
Added 11 new sites: Orange, California, Atlanta, Georgia, Columbus, Ohio and 8 more
Eligibility criteria have been updated
Added 1 new site: Salamanca, Spain
Target enrollment increased from 40 to 70
Eligibility criteria have been updated
Added 5 new sites: Nagoya, Japan, Maebashi, Japan, Shinjuku-ku, Japan and 2 more
Added 90 new sites: Birmingham, Alabama, Huntington Park, California, Los Angeles, California and 87 more
Eligibility criteria have been updated
Added 1 new site: São Paulo, Brazil
Added 2 new sites: Atlanta, Georgia, Cologne, Germany
Eligibility criteria have been updated
Eligibility criteria have been updated
Added 4 new sites: Charlotte, North Carolina, Colombia, South Carolina, Markham, Canada and 1 more
Added 7 new sites: Phoenix, Arizona, Charlotte, North Carolina, Namur, Belgium and 4 more
Added 3 new sites: Cullman, Alabama, Boulder, Colorado, Kansas City, Kansas
Added 2 new sites: Little Rock, Arkansas, Kansas City, Kansas
Added 6 new sites: Fitzroy, Australia, Halle, Germany, Lübeck, Germany and 3 more
Reduced from 207 to 194 sites
Target enrollment decreased from 120 to 58
Added 7 new sites: Pasadena, California, Homestead, Florida, Chicago, Illinois and 4 more
Added 2 new sites: Mission Hills, California, Poznan, Poland
Added 2 new sites: Pittsburgh, Pennsylvania, Barcelona, Spain
Reduced from 56 to 50 sites
Eligibility criteria have been updated
Added 5 new sites: Gdansk, Poland, Lublin, Poland, Constanța, Romania and 2 more
Eligibility criteria have been updated
Added 3 new sites: Irvine, California, Austin, Texas, Milwaukee, Wisconsin
Eligibility criteria have been updated
Added 1 new site: Scottsdale, Arizona
Added 1 new site: Tampa, Florida
Eligibility criteria have been updated
Added 3 new sites: Roseville, Missouri, New York, New York, Kawasaki-shi, Japan
Eligibility criteria have been updated
Added 4 new sites: Cali, Colombia, Maastricht, Netherlands, Krakow, Poland and 1 more
Added 2 new sites: Wheaton, Maryland, Ann Arbor, Michigan
Added 3 new sites: Beijing, China, Chiba, Japan, Seoul, South Korea
Added 5 new sites: Woolloongabba, Australia, Heidelberg, Germany, Leipzig, Germany and 2 more
Added 3 new sites: Curicó, Chile, Ñuñoa, Chile, Santiago, Chile
Added 14 new sites: Houston, Texas, San Miguel de Tucumán, Argentina, Buenos Aires, Argentina and 11 more
Eligibility criteria have been updated
Added 1 new site: Montral, Canada
Eligibility criteria have been updated
Added 7 new sites: Camperdown, Australia, Herston, Australia, Herston, Australia and 4 more
Added 3 new sites: Baton Rouge, Louisiana, Cleveland, Ohio, Roma, Italy
Added 1 new site: Warsaw, Poland
Added 2 new sites: Morehead City, North Carolina, Chattanooga, Tennessee
Added 1 new site: Marseille, France
Added 2 new sites: Houston, Texas, Melbourne, Australia
Added 17 new sites: Aurora, Colorado, Iowa City, Iowa, Bonn, Germany and 14 more
Added 1 new site: San Francisco, California
Added 18 new sites: Aurora, Colorado, Tampa, Florida, Leuven, Belgium and 15 more
Added 4 new sites: Farmington Hills, Michigan, Dallas, Texas, San Antonio, Texas and 1 more
Added 1 new site: Arecibo, Puerto Rico
Added 2 new sites: Palo Alto, California, Sacramento, California
Added 1 new site: Durham, North Carolina
Added 6 new sites: Bordeaux, France, Lyon, France, Saint-Cyr-sur-Loire, France and 3 more
Added 9 new sites: Northridge, California, Kansas City, Kansas, Columbus, Mississippi and 6 more
Added 1 new site: Miami, Florida
Added 2 new sites: Gulf Breeze, Florida, Philadelphia, Pennsylvania
Added 1 new site: Milwaukee, Wisconsin
Added 3 new sites: Beijing, China, Guangzhou, China, Wuhan, China
Added 1 new site: Seattle, Washington
Added 22 new sites: Los Angeles, California, Stanford, California, Baltimore, Maryland and 19 more
Added 1 new site: Chicago, Illinois
Added 1 new site: Buenos Aires, Argentina
Target enrollment increased from 10 to 15
Eligibility criteria have been updated
Target enrollment increased from 220 to 299
Added 3 new sites: Augsburg, Germany, Berlin, Germany, Passau, Germany
Added 1 new site: Belgrade, Serbia
Added 1 new site: Miami, Florida
Added 5 new sites: Los Angeles, California, Davie, Florida, Chicago, Illinois and 2 more
Eligibility criteria have been updated
Target enrollment increased from 15 to 25
Added 2 new sites: London, United Kingdom, Sheffield, United Kingdom
Added 4 new sites: Cali, Colombia, Maastricht, Netherlands, Krakow, Poland and 1 more
Added 2 new sites: Wheaton, Maryland, Ann Arbor, Michigan
Added 2 new sites: Palo Alto, California, Sacramento, California
Added 2 new sites: Detroit, Michigan, Farmington Hills, Michigan
Added 1 new site: Jacksonville, Florida
Added 2 new sites: Distrito Federal, Brazil, Guangzhou, China
Target enrollment decreased from 120 to 10
Target enrollment increased from 60 to 106
Added 1 new site: Chicago, Illinois
Target enrollment decreased from 300 to 59
Added 7 new sites: Camperdown, Australia, Herston, Australia, Herston, Australia and 4 more
Added 2 new sites: Nanjing, China, Xiamen, China
Added 2 new sites: Houston, Texas, Seattle, Washington
Added 6 new sites: Camperdown, Australia, Busan, South Korea, Seongnam-si, South Korea and 3 more
Target enrollment decreased from 35 to 28
Target enrollment decreased from 60 to 31
Reduced from 14 to 12 sites
Added 1 new site: Washington D.C., District of Columbia
Added 5 new sites: Anderlecht, Belgium, Dresden, Germany, Rotterdam, Netherlands and 2 more
Added 16 new sites: Scottsdale, Arizona, Westmead, Australia, Shanghai, China and 13 more
Added 33 new sites: Brussels, Belgium, Leuven, Belgium, Leuven, Belgium and 30 more
Eligibility criteria have been updated
Added 33 new sites: Brussels, Belgium, Leuven, Belgium, Leuven, Belgium and 30 more
Added 3 new sites: Tampa, Florida, Nashville, Tennessee, Houston, Texas
Added 1 new site: Changhua, Taiwan
Added 3 new sites: Paris, France, Florence, Italy, Târgu Mureş, Romania
Added 3 new sites: Colorado Springs, Colorado, Flowood, Mississippi, Dublin, Ohio
Added 4 new sites: Pusan, South Korea, Daegu, South Korea, Seoul, South Korea and 1 more
Added 5 new sites: Salt Lake City, Utah, Marseille, France, Bonn, Germany and 2 more
Added 3 new sites: Tampa, Florida, Nashville, Tennessee, Houston, Texas
Eligibility criteria have been updated
Target enrollment increased from 45 to 57
Eligibility criteria have been updated
Added 3 new sites: Macquarie University, Australia, Haifa, Israel, Tel Aviv, Israel
Target enrollment increased from 88 to 108
Eligibility criteria have been updated
Eligibility criteria have been updated
Added 5 new sites: Oakland, California, Roseville, California, Santa Clara, California and 2 more
Eligibility criteria have been updated
Added 1 new site: Tampa, Florida
Target enrollment decreased from 435 to 66
Eligibility criteria have been updated
Added 10 new sites: Boston, Massachusetts, Chattanooga, Tennessee, Berlin, Germany and 7 more
Added 1 new site: Cincinnati, Ohio
Added 2 new sites: New York, New York, Cordova, Tennessee
Added 4 new sites: Boston, Massachusetts, São Paulo, Brazil, Chiba, Japan and 1 more
Eligibility criteria have been updated
Added 4 new sites: Houston, Texas, Caba, Argentina, Mexico City, Mexico and 1 more
Added 9 new sites: Boston, Massachusetts, Berlin, Germany, Athens, Greece and 6 more
Added 1 new site: Valencia, Spain
Added 4 new sites: Seattle, Washington, Calgary, Canada, Saint-Herblain, France and 1 more
Added 20 new sites: Dallas, Texas, CABA, Argentina, San Juan, Argentina and 17 more
Added 3 new sites: Siegen, Germany, Görlitz, Germany, Oldenburg, Germany
Reduced from 149 to 147 sites
Added 17 new sites: Pleven, Bulgaria, Zagreb, Croatia, Tbilisi, Georgia and 14 more
Added 2 new sites: Shtip, North Macedonia, Skopje, North Macedonia
Added 5 new sites: Naples, Florida, Nowa Sól, Poland, Rzeszów, Poland and 2 more
Eligibility criteria have been updated
Added 1 new site: Almería, Spain
Target enrollment increased from 24 to 36
Eligibility criteria have been updated
Added 1 new site: Kuala Lumpur, Malaysia
Added 5 new sites: Bergamo, Italy, Pavia, Italy, Gyeonggi-do, South Korea and 2 more
Eligibility criteria have been updated
Added 4 new sites: Rosario, Argentina, Rosario, Argentina, San Miguel de Tucumán, Argentina and 1 more
Eligibility criteria have been updated
Reduced from 194 to 192 sites
Added 2 new sites: Bron, France, Le Kremlin-Bicêtre, France
Added 10 new sites: Stanford, California, Detroit, Michigan, Chapel Hill, North Carolina and 7 more
Added 1 new site: Fort Wayne, Indiana
Added 1 new site: Houston, Texas
Target enrollment decreased from 250 to 118
Eligibility criteria have been updated
Added 13 new sites: Prague, Czechia, Paris, France, Ashkelon, Israel and 10 more