Rare Disease Trial Updates: May 2026
In May 2026, Trial Friend tracked 546 rare disease clinical trial updates across 105 conditions, including 2 FDA-related actions and 61 trial status changes, alongside enrollment updates and new trial site openings sourced from ClinicalTrials.gov and FDA announcements.
This is a permanent monthly archive. For the latest updates, see the live current events feed.
Major Updates: FDA Actions, Status Changes & Results
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
Now recruiting (was Active Not Recruiting)
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
Status changed from Recruiting to Enrolling By Invitation
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
Now recruiting (was Active Not Recruiting)
The FDA granted orphan drug designation to rituximab, developed by ODDIFACT SAS, on 2026-05-12 for the treatment of chronic graft-versus-host disease. Orphan designation is an incentive for rare disease drug development, not an approval: it gives the sponsor tax credits, fee waivers, and 7 years of market exclusivity if the drug is eventually approved. It often signals that a company is committing to a full development program.
No longer enrolling new participants
No longer enrolling new participants
Now recruiting (was Active Not Recruiting)
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
Now recruiting (was Active Not Recruiting)
No longer enrolling new participants
FDA issued an approval for Bizengri (zenocutuzumab-zbco), a drug that treats NRG1 fusion-positive cholangiocarcinoma, an ultra-rare, aggressive cancer that forms in the bile ducts.
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
Now recruiting (was Active Not Recruiting)
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
Trial Site & Enrollment Activity
Added 1 new site: Sejong, South Korea
Added 2 new sites: Palo Alto, California, St Louis, Missouri
Added 1 new site: Nashville, Tennessee
Target enrollment decreased from 127 to 99
Added 1 new site: Boston, Massachusetts
Added 2 new sites: Paris, France, Valencia, Spain
Added 1 new site: Bergamo, Italy
Added 7 new sites: Boston, Massachusetts, Detroit, Michigan, CABA, Argentina and 4 more
Added 2 new sites: Tel Aviv, Israel, Milan, Italy
Eligibility criteria have been updated
Added 8 new sites: Phoenix, Arizona, Northbrook, Illinois, Teaneck, New Jersey and 5 more
Eligibility criteria have been updated
Added 1 new site: Chicago, Illinois
Reduced from 225 to 223 sites
Added 11 new sites: Chicago, Illinois, Rosario, Argentina, Murdoch, Australia and 8 more
Added 6 new sites: Arnsdorf, Germany, Berg, Germany, Frankfurt, Germany and 3 more
Added 3 new sites: Bradenton, Florida, Rochester Hills, Michigan, St Louis, Missouri
Added 2 new sites: Irvine, California, Hradec Králové, Czechia
Added 3 new sites: Tulza, Bosnia and Herzegovina, Kragujevac, Serbia, Niš, Serbia
Added 1 new site: Savannah, Georgia
Added 3 new sites: Billings, Montana, Norman, Oklahoma, Ogden, Utah
Added 2 new sites: Pheonix, Arizona, West Hollywood, California
Added 31 new sites: New York, New York, Philadelphia, Pennsylvania, Clayton, Australia and 28 more
Target enrollment increased from 764 to 884
Eligibility criteria have been updated
Added 1 new site: Chūō, Japan
Added 4 new sites: Los Angeles, California, New York, New York, Shanghai, China and 1 more
Added 2 new sites: Opole, Poland, Seoul, South Korea
Eligibility criteria have been updated
Added 8 new sites: Huangshan City, China, Wuhu, China, Zhanjiang, China and 5 more
Added 1 new site: Parkville, Australia
Added 2 new sites: Georgetown, Texas, Southampton, United Kingdom
Added 7 new sites: Innsbruck, Austria, Linz, Austria, Vienna, Austria and 4 more
Added 52 new sites: Phoenix, Arizona, New Haven, Connecticut, Atlanta, Georgia and 49 more
Eligibility criteria have been updated
Added 1 new site: Los Angeles, California
Added 4 new sites: Los Angeles, California, Jacksonville, Florida, Miami Beach, Florida and 1 more
Eligibility criteria have been updated
Added 2 new sites: Padova, Italy, San Donato Milanese, Italy
Eligibility criteria have been updated
Added 24 new sites: Aarhus, Denmark, Copenhagen, Denmark, Marseille, France and 21 more
Added 15 new sites: Fortaleza, Brazil, Porto Alegre, Brazil, São Paulo, Brazil and 12 more
Added 1 new site: Nashville, Tennessee
Reduced from 11 to 2 sites
Eligibility criteria have been updated
Added 1 new site: Taichung, Taiwan
Added 1 new site: Taichung, Taiwan
Added 4 new sites: Phoenix, Arizona, Carlsbad, California, Jacksonville, Florida and 1 more
Added 1 new site: Wesley Chapel, Florida
Added 2 new sites: Bucharest, Romania, Cluj-Napoca, Romania
Added 3 new sites: Pécs, Hungary, Bydgoszcz, Poland, Krakow, Poland
Added 2 new sites: London, United Kingdom, Southampton, United Kingdom
Eligibility criteria have been updated
Target enrollment decreased from 550 to 476
Eligibility criteria have been updated
Added 1 new site: Fort Wayne, Indiana
Added 1 new site: Ann Arbor, Michigan
Added 1 new site: Amarillo, Texas
Added 1 new site: Nanjing, China
Added 13 new sites: Linz, Austria, Sofia, Bulgaria, Fuzhou, China and 10 more
Eligibility criteria have been updated
Added 1 new site: Columbus, Ohio
Added 1 new site: Baltimore, Maryland
Reduced from 43 to 26 sites
Target enrollment decreased from 39 to 26
Target enrollment decreased from 255 to 165
Added 5 new sites: Centennial, Colorado, Bradenton, Florida, Kansas City, Kansas and 2 more
Added 2 new sites: Kansas City, Kansas, Philadelphia, Pennsylvania
Added 1 new site: Budapest, Hungary
Added 4 new sites: Cleveland, Ohio, Adelaide, Australia, Roeselare, Belgium and 1 more
Added 7 new sites: Portland, Oregon, Fuzhou, China, Guangzhou, China and 4 more
Target enrollment decreased from 20 to 1
Added 2 new sites: Brisbane, Australia, Fredericton, Canada
Added 7 new sites: Portland, Oregon, Fuzhou, China, Guangzhou, China and 4 more
Added 2 new sites: Saint Louis Park, Minnesota, Appleton, Wisconsin
Added 14 new sites: Little Rock, Arkansas, Hollywood, Florida, Columbus, Ohio and 11 more
Added 1 new site: Nashville, Tennessee
Eligibility criteria have been updated
Added 1 new site: Nampa, Idaho
Target enrollment decreased from 36 to 21
Added 1 new site: Hanover, Germany
Added 4 new sites: Buenos Aires, Argentina, Ghent, Belgium, Brno, Czechia and 1 more
Added 1 new site: Lisbon, Portugal
Reduced from 44 to 22 sites
Added 27 new sites: Tucson, Arizona, Chula Vista, California, Los Angeles, California and 24 more
Added 1 new site: Durham, North Carolina
Target enrollment decreased from 50 to 32
Added 1 new site: Edmonton, Canada
Added 5 new sites: Orange, California, Dallas, Texas, Blumenau, Brazil and 2 more
Added 1 new site: Rochester, Minnesota
Added 4 new sites: Chicago, Illinois, Ann Arbor, Michigan, Chapel Hill, North Carolina and 1 more
Target enrollment increased from 100 to 132
Expanded from 4 to 5 sites
Added 3 new sites: Le Kremlin-Bicêtre, France, Hanover, Germany, Seoul, South Korea
Added 1 new site: Palo Alto, California
Eligibility criteria have been updated
Eligibility criteria have been updated
Added 1 new site: Changchun, China
Added 3 new sites: Boca Raton, Florida, Houston, Texas, Waxahachie, Texas
Added 2 new sites: Huntsville, Alabama, Rosario, Argentina
Added 5 new sites: Farmington, Connecticut, Cincinnati, Ohio, Camperdown, Australia and 2 more
Eligibility criteria have been updated
Eligibility criteria have been updated
Added 2 new sites: La Jolla, California, Roma, Italy
Added 26 new sites: Heidelberg, Australia, Nîmes, France, Saint-Herblain, France and 23 more
Added 5 new sites: Hradec Králové, Czechia, Tallinn, Estonia, 's-Hertogenbosch, Netherlands and 2 more
Target enrollment decreased from 15 to 9
Eligibility criteria have been updated
Added 3 new sites: Miami, Florida, Weston, Florida, Columbus, Ohio
Added 1 new site: Houston, Texas
Added 7 new sites: Scottsdale, Arizona, Bradenton, Florida, St Louis, Missouri and 4 more
Added 1 new site: Gilbert, Arizona
Target enrollment decreased from 800 to 300
Eligibility criteria have been updated
Eligibility criteria have been updated
Eligibility criteria have been updated
Added 4 new sites: Stanford, California, Nashville, Tennessee, Lucknow, India and 1 more
Added 1 new site: Parkville, Australia
Target enrollment increased from 96 to 120
Eligibility criteria have been updated
Added 1 new site: Kansas City, Kansas
Added 4 new sites: Buenos Aires, Argentina, Ghent, Belgium, Brno, Czechia and 1 more
Added 2 new sites: Hong Kong, China, Sheffield, United Kingdom
Added 9 new sites: Midland, Australia, Spearwood, Australia, Trois-Rivières, Canada and 6 more
Eligibility criteria have been updated
Added 2 new sites: Philadelphia, Pennsylvania, Montreal, Canada
Eligibility criteria have been updated
Added 1 new site: Krakow, Poland
Added 9 new sites: Little Rock, Arkansas, San Diego, California, Santa Monica, California and 6 more
Added 2 new sites: Miami, Florida, Hershey, Pennsylvania
Added 1 new site: Cambridge, United Kingdom
Added 10 new sites: Fortaleza, Brazil, Brasília, Brazil, Curitiba, Brazil and 7 more
Added 1 new site: Los Angeles, California
Eligibility criteria have been updated
Eligibility criteria have been updated
Reduced from 27 to 24 sites
Eligibility criteria have been updated
Added 1 new site: Nashville, Tennessee
Added 2 new sites: Toronto, Canada, Adana, Turkey (Türkiye)
Added 2 new sites: Toronto, Canada, Adana, Turkey (Türkiye)
Added 3 new sites: Seoul, South Korea, Seoul, South Korea, Ulsan, South Korea
Added 10 new sites: Oakland, California, Redwood City, California, San Francisco, California and 7 more
Added 7 new sites: Los Angeles, California, Jacksonville, Florida, Tampa, Florida and 4 more
Added 3 new sites: Rome, Italy, Barcelona, Spain, Uppsala, Sweden
Added 2 new sites: Boston, Massachusetts, Philadelphia, Pennsylvania
Reduced from 22 to 19 sites
Eligibility criteria have been updated
Added 12 new sites: Washington D.C., District of Columbia, Edegem, Belgium, Porto Alegre, Brazil and 9 more
Added 1 new site: Rochester, Minnesota
Reduced from 3 to 1 sites
Target enrollment decreased from 12 to 5
Eligibility criteria have been updated
Added 1 new site: Rochester, Minnesota
Added 17 new sites: Allen, Texas, Beckley, West Virginia, SAN M. de Tucuman, Argentina and 14 more
Added 10 new sites: Atlanta, Georgia, Pittsburgh, Pennsylvania, Dallas, Texas and 7 more
Added 4 new sites: Hershey, Pennsylvania, Houston, Texas, Belo Horizonte, Brazil and 1 more
Added 3 new sites: Rancho Mirage, California, New York, New York, Sherman, Texas
Added 6 new sites: Milan, Italy, Naples, Italy, Pisa, Italy and 3 more
Eligibility criteria have been updated
Added 2 new sites: Grand Rapids, Michigan, Philadelphia, Pennsylvania
Reduced from 25 to 21 sites
Reduced from 22 to 19 sites
Eligibility criteria have been updated
Added 11 new sites: Baltimore, Maryland, São Paulo, Brazil, Le Kremlin-Bicêtre, France and 8 more
Added 15 new sites: Evanston, Illinois, Portland, Oregon, Charleston, South Carolina and 12 more
Reduced from 86 to 74 sites
Eligibility criteria have been updated
Added 5 new sites: Nagoya, Japan, Fukuoka, Japan, Koto-ku, Japan and 2 more
Added 2 new sites: Le Kremlin-Bicêtre, France, Seoul, South Korea
Added 4 new sites: Kyoto, Japan, Sakai-shi, Japan, Chuo-shi, Japan and 1 more
Added 1 new site: Southaven, Mississippi
Eligibility criteria have been updated
Added 1 new site: Providence, Rhode Island
Added 1 new site: Orange, California
Eligibility criteria have been updated
Added 2 new sites: Louisville, Kentucky, Greenville, North Carolina
Eligibility criteria have been updated
Added 2 new sites: Milan, Italy, Torino, Italy
Eligibility criteria have been updated
Added 36 new sites: Costa Mesa, California, Orange, California, Sacramento, California and 33 more
Added 6 new sites: Houston, Texas, Calgary, Canada, Hanover, Germany and 3 more
Added 1 new site: Cambridge, United Kingdom
Added 1 new site: Ulm, Germany
Added 4 new sites: Balçova, Turkey (Türkiye), Rize, Turkey (Türkiye), Sanliurfa, Turkey (Türkiye) and 1 more
Target enrollment decreased from 150 to 102
Added 1 new site: Coral Springs, Florida
Added 1 new site: Sydney, Australia
Added 1 new site: Genolier, Switzerland
Added 1 new site: Sacramento, California
Added 2 new sites: Nashville, Tennessee, Groningen, Netherlands
Added 1 new site: Concord, Australia
Added 1 new site: Guangzhou, China
Added 3 new sites: Seoul, South Korea, Murcia, Spain, Salamanca, Spain
Added 12 new sites: Los Angeles, California, Atlanta, Georgia, Chicago, Illinois and 9 more
Target enrollment decreased from 54 to 30
Moved from Phase 4 to Phase 3
Added 3 new sites: Stanford, California, Gainesville, Florida, St Louis, Missouri
Added 1 new site: Coral Springs, Florida
Added 5 new sites: Bologna, Italy, Milan, Italy, Madrid, Spain and 2 more
Added 1 new site: Sydney, Australia
Added 1 new site: Genolier, Switzerland
Added 1 new site: Sacramento, California
Reduced from 7 to 1 sites
Eligibility criteria have been updated
Added 2 new sites: Los Angeles, California, Stony Brook, New York
Added 1 new site: Sydney, Australia
Added 1 new site: Stony Brook, New York
Eligibility criteria have been updated
Added 26 new sites: Kansas City, Missouri, Lake Success, New York, Winston-Salem, North Carolina and 23 more
Added 1 new site: Saint Petersburg, Russia
Added 2 new sites: Columbia, Missouri, Munich, Germany
Added 1 new site: Porto Alegre, Brazil
Added 1 new site: Düsseldorf, Germany
Reduced from 384 to 382 sites
Target enrollment increased from 1600 to 1655
Target enrollment increased from 500 to 2000
Added 15 new sites: Homestead, Florida, Foxborough, Massachusetts, Greenville, South Carolina and 12 more
Reduced from 338 to 311 sites
Added 3 new sites: Buffalo, New York, São Paulo, Brazil, Bochum, Germany
Added 6 new sites: Fort Collins, Colorado, Ghent, Belgium, Chengdu, China and 3 more
Added 1 new site: Pensacola, Florida
Added 1 new site: Tampa, Florida
Added 2 new sites: Tustin, California, Summit, New Jersey
Added 7 new sites: Belo Horizonte, Brazil, Harbin, China, Shijiazhuang, China and 4 more
Added 2 new sites: Nashville, Tennessee, Pavia, Italy
Added 2 new sites: Doral, Florida, Cleveland, Ohio
Target enrollment increased from 30 to 1000
Eligibility criteria have been updated
Added 3 new sites: The Woodlands, Texas, Vienna, Austria, Exeter, United Kingdom
Added 1 new site: Manchester, United Kingdom
Reduced from 7 to 1 sites
Eligibility criteria have been updated
Target enrollment increased from 60 to 80
Target enrollment decreased from 30 to 18
Target enrollment increased from 88 to 118
Eligibility criteria have been updated
Added 1 new site: Madrid, Spain
Added 1 new site: London, United Kingdom
Added 11 new sites: Rancho Cordova, California, Sacramento, California, Sacramento, California and 8 more
Added 13 new sites: Sacramento, California, Sacramento, California, Metairie, Louisiana and 10 more
Added 1 new site: Stasbourg, France
Added 11 new sites: Rancho Cordova, California, Sacramento, California, Sacramento, California and 8 more
Added 4 new sites: Greenville, North Carolina, Canton, Ohio, Memphis, Tennessee and 1 more
Added 2 new sites: Erie, Pennsylvania, Bellaire, Texas
Added 10 new sites: Brunswick, Georgia, Ahmedabad, India, Dehradun, India and 7 more
Added 3 new sites: Buenos Aires, Argentina, San Luis, Argentina, Kuopio, Finland
Added 1 new site: Portland, Oregon
Added 1 new site: Sacramento, California
Added 3 new sites: Amarillo, Texas, Dallas, Texas, Webster, Texas
Added 1 new site: Coral Springs, Florida
Added 1 new site: Genolier, Switzerland
Added 1 new site: Sydney, Australia
Reduced from 25 to 21 sites
Added 13 new sites: Birmingham, Alabama, Little Rock, Arkansas, Morrisville, North Carolina and 10 more
Added 2 new sites: Los Angeles, California, Denver, Colorado
Target enrollment increased from 24 to 64
Eligibility criteria have been updated
Added 1 new site: Chiba, Japan
Target enrollment increased from 600 to 1211
Target enrollment increased from 6 to 9
Eligibility criteria have been updated
Target enrollment increased from 600 to 1211
Reduced from 24 to 7 sites
Added 1 new site: Boise, Idaho
Target enrollment increased from 12 to 20
Eligibility criteria have been updated
Added 6 new sites: Washington D.C., District of Columbia, St Louis, Missouri, Cleveland, Ohio and 3 more
Target enrollment increased from 12 to 33
Eligibility criteria have been updated
Added 14 new sites: Nashville, Tennessee, Buenos Aires, Argentina, Liverpool, Australia and 11 more
Added 5 new sites: Marseille, France, Nîmes, France, Milan, Italy and 2 more
Added 27 new sites: Tampa, Florida, Rosario, Argentina, Vienna, Austria and 24 more
Added 24 new sites: Rancho Mirage, California, Naples, Florida, Philadelphia, Pennsylvania and 21 more
Added 1 new site: Tampa, Florida
Eligibility criteria have been updated
Added 1 new site: Los Alamitos, California
Target enrollment increased from 600 to 1211
Target enrollment increased from 6 to 9
Eligibility criteria have been updated
Added 2 new sites: Iruma-gun, Japan, Mersin, Turkey (Türkiye)
Target enrollment decreased from 125 to 65
Eligibility criteria have been updated
Added 3 new sites: Seattle, Washington, Murdoch, Australia, Woolloongabba, Australia
Eligibility criteria have been updated
Reduced from 9 to 7 sites
Target enrollment decreased from 700 to 119
Added 2 new sites: California City, California, Parkville, Australia
Reduced from 20 to 17 sites
Reduced from 82 to 80 sites
Added 2 new sites: Birmingham, Alabama, Augusta, Georgia
Added 2 new sites: Little Rock, Arkansas, Bethesda, Maryland
Added 1 new site: Shenyang, China
Added 2 new sites: Melbourne, Australia, Warsaw, Poland
Target enrollment increased from 600 to 1211
Added 3 new sites: Kansas City, Missouri, Rochester, New York, Montreal, Canada
Added 2 new sites: Royal Oak, Michigan, Westbury, New York
Added 1 new site: Phoenix, Arizona
Moved from Phase 2 to N/A
Target enrollment increased from 70 to 145
Eligibility criteria have been updated
Added 1 new site: Atlanta, Georgia
Eligibility criteria have been updated
Added 3 new sites: Bellaire, Texas, Milan, Italy, Rome, Italy
Reduced from 67 to 31 sites
Added 2 new sites: Dallas, Texas, Oxford, United Kingdom
Added 1 new site: Berkeley Heights, New Jersey
Target enrollment decreased from 26 to 10
Added 3 new sites: Tours, France, Dublin, Ireland, Warsaw, Poland
Added 2 new sites: Brookline, Massachusetts, Cincinnati, Ohio
Added 1 new site: Okayama, Japan
Added 11 new sites: Middletown, New Jersey, Durham, North Carolina, Winston-Salem, North Carolina and 8 more
Added 6 new sites: Brandon, Florida, Macon, Georgia, Lansing, Michigan and 3 more
Added 1 new site: Toyonaka-Shi, Japan
Added 1 new site: Berkeley Heights, New Jersey
Target enrollment decreased from 26 to 10
Reduced from 53 to 49 sites
Target enrollment decreased from 58 to 30
Target enrollment decreased from 70 to 6
Added 2 new sites: Los Angeles, California, Pembroke Pines, Florida
Added 9 new sites: Aarhus, Denmark, Copenhagen, Denmark, Berlin, Germany and 6 more
Added 1 new site: Winfield, Illinois
Reduced from 169 to 144 sites
Moved from Phase 2 to N/A
Added 2 new sites: Córdoba, Argentina, Joinville, Brazil
Added 4 new sites: Pomona, California, Fort Collins, Colorado, Raleigh, North Carolina and 1 more
Added 1 new site: Niš, Serbia
Added 2 new sites: Denton, Texas, Ankara, Turkey (Türkiye)
Added 3 new sites: Boca Raton, Florida, Homestead, Florida, Las Vegas, Nevada
Added 34 new sites: Tampa, Florida, Mendoza, Argentina, Liège, Belgium and 31 more
Added 2 new sites: Salerno, Italy, Niigata, Japan
Target enrollment decreased from 386 to 300
Target enrollment decreased from 250 to 50
Added 22 new sites: Washington D.C., District of Columbia, Miami, Florida, Albuquerque, New Mexico and 19 more
Added 4 new sites: Birmingham, Alabama, Southfield, Michigan, Hradec Králové, Czechia and 1 more
Added 1 new site: Lublin, Poland
Added 4 new sites: Scottsdale, Arizona, Boston, Massachusetts, San Antonio, Texas and 1 more
Added 4 new sites: Albstadt, Germany, Magdeburg, Germany, Schneverdingen, Germany and 1 more
Reduced from 45 to 42 sites
Added 2 new sites: St Albans, Australia, Chandigarh, India
Target enrollment increased from 600 to 1211
Added 3 new sites: Kansas City, Missouri, Rochester, New York, Montreal, Canada
Added 4 new sites: Guangzhou, China, Changchun, China, Changchun, China and 1 more
Eligibility criteria have been updated
Added 84 new sites: Goodyear, Arizona, Tucson, Arizona, Tucson, Arizona and 81 more
Added 5 new sites: Philadelphia, Pennsylvania, Santa Fe, Argentina, Fontevivo, Italy and 2 more
Added 158 new sites: Birmingham, Alabama, Los Angeles, California, Palo Alto, California and 155 more
Eligibility criteria have been updated
Added 10 new sites: Orlando, Florida, New York, New York, Dallas, Texas and 7 more
Added 3 new sites: Atlanta, Georgia, Pittsburgh, Pennsylvania, Curitiba, Brazil
Added 3 new sites: Aurora, Colorado, Houston, Texas, Salt Lake City, Utah
Added 3 new sites: Copenhagen, Denmark, Leicester, United Kingdom, Norwich, United Kingdom
Added 2 new sites: New Haven, Connecticut, Edinburgh, United Kingdom
Added 1 new site: McKinney, Texas
Added 1 new site: Houston, Texas
Added 1 new site: New York, New York
Added 15 new sites: La Louvière, Belgium, Leuven, Belgium, Cerqueira César, Brazil and 12 more
Added 52 new sites: Phoenix, Arizona, New Haven, Connecticut, Atlanta, Georgia and 49 more
Eligibility criteria have been updated
Eligibility criteria have been updated
Target enrollment decreased from 9300 to 2323
Added 2 new sites: Dallas, Texas, Milan, Italy
Added 37 new sites: Birmingham, Alabama, Scottsdale, Arizona, Little Rock, Arkansas and 34 more
Added 3 new sites: Metairie, Louisiana, Nashville, Tennessee, Lublin, Poland
Added 6 new sites: Parkville, Australia, Campinas, Brazil, Rio de Janeiro, Brazil and 3 more
Added 2 new sites: London, United Kingdom, Newcastle upon Tyne, United Kingdom
Target enrollment increased from 600 to 1211
Added 1 new site: Berkeley Heights, New Jersey
Reduced from 25 to 12 sites
Reduced from 17 to 8 sites
Reduced from 66 to 34 sites
Added 3 new sites: Orange, California, Indianapolis, Indiana, Seattle, Washington
Reduced from 17 to 8 sites
Reduced from 66 to 34 sites
Added 7 new sites: Sacramento, California, Toms River, New Jersey, Houston, Texas and 4 more
Added 1 new site: La Crosse, Wisconsin
Target enrollment decreased from 132 to 27
Added 2 new sites: Gloucester, United Kingdom, London, United Kingdom
Added 18 new sites: Fullerton, California, Tampa, Florida, Elmhurst, Illinois and 15 more
Eligibility criteria have been updated
Added 4 new sites: Manchester, Connecticut, Fort Worth, Texas, Tyler, Texas and 1 more
Added 1 new site: Chicago, Illinois
Eligibility criteria have been updated
Reduced from 45 to 42 sites
Added 1 new site: Durham, North Carolina
Added 3 new sites: Edmonton, Canada, Santiago de Compostela, Spain, Taoyuan, Taiwan
Added 1 new site: West Perth, Australia
Target enrollment decreased from 26 to 10
Added 3 new sites: Eugene, Oregon, L'Hospitalet de Llobregat, Spain, Taoyuan, Taiwan
Expanded from 3 to 4 sites
Eligibility criteria have been updated
Added 1 new site: Memphis, Tennessee
Target enrollment decreased from 35 to 17
Eligibility criteria have been updated
Added 1 new site: Las Vegas, Nevada
Added 3 new sites: Bradenton, Florida, Las Vegas, Nevada, Milan, Italy
Added 2 new sites: Bonn, Germany, Ulm, Germany
Reduced from 45 to 42 sites
Added 1 new site: Berlin, Germany
Added 2 new sites: Indianapolis, Indiana, Winnipeg, Canada
Target enrollment decreased from 12 to 6
Eligibility criteria have been updated
Added 5 new sites: Shanghai, China, Hebei Sheng, China, Shaanxi, China and 2 more
Eligibility criteria have been updated
Added 1 new site: Rochester, New York
Eligibility criteria have been updated
Added 4 new sites: New York, New York, South Brisbane, Australia, Petah Tikva, Israel and 1 more
Added 5 new sites: Shanghai, China, Hebei Sheng, China, Shaanxi, China and 2 more
Added 3 new sites: Mutlangen, Germany, Paderborn, Germany, Rostock, Germany
Added 2 new sites: Phoenix, Arizona, Gainesville, Florida
Target enrollment decreased from 9300 to 2323
Added 1 new site: Braunau am Inn, Austria
Added 1 new site: Richmond, Australia
Added 2 new sites: Atlanta, Georgia, Leeds, United Kingdom
Added 8 new sites: Pittsburgh, Pennsylvania, Providence, Rhode Island, Charleston, South Carolina and 5 more
Added 1 new site: Saint Petersburg, Russia
Target enrollment decreased from 500 to 340
Added 1 new site: Tampa, Florida
Eligibility criteria have been updated
Added 1 new site: Masaka, Uganda
Added 1 new site: Salford, United Kingdom
Added 1 new site: London, United Kingdom
Added 54 new sites: Scottsdale, Arizona, Orange, California, Orlando, Florida and 51 more
Added 1 new site: Gyeongsang, South Korea
Added 3 new sites: Guadalajara, Mexico, Monterrey, Mexico, Chiang Mai, Thailand
Added 6 new sites: Bobigny, France, Beersheba, Israel, Tel Aviv, Israel and 3 more
Added 7 new sites: Grand Rapids, Michigan, Minneapolis, Minnesota, Minneapolis, Minnesota and 4 more
Added 1 new site: Seoul, South Korea
Added 1 new site: West Perth, Australia
Added 4 new sites: Palo Alto, California, Charlotte, North Carolina, Concord, North Carolina and 1 more
Added 2 new sites: Cleveland, Ohio, Milwaukee, Wisconsin
Eligibility criteria have been updated
Target enrollment increased from 45 to 240
Eligibility criteria have been updated
Reduced from 63 to 61 sites
Added 2 new sites: Cleveland, Ohio, Milwaukee, Wisconsin
Eligibility criteria have been updated
Added 8 new sites: El Paso, Texas, Léon, France, Bologna, Italy and 5 more
Target enrollment increased from 96 to 248
Added 1 new site: Richmond, Virginia
Eligibility criteria have been updated
Eligibility criteria have been updated
Added 1 new site: Seoul, South Korea
Added 1 new site: West Perth, Australia
Added 4 new sites: Palo Alto, California, Charlotte, North Carolina, Concord, North Carolina and 1 more
Added 4 new sites: Madrid, Spain, Boston, United Kingdom, Belfast, United Kingdom and 1 more
Added 1 new site: Aomori, Japan
Added 1 new site: West Perth, Australia
Added 1 new site: Göttingen, Germany
Added 3 new sites: Innsbruck, Austria, Calgary, Canada, Stockholm, Sweden
Added 6 new sites: Amberg, Germany, Celle, Germany, Frankfurt, Germany and 3 more
Reduced from 122 to 120 sites
Added 4 new sites: Orlando, Florida, Las Vegas, Nevada, Overpelt, Belgium and 1 more
Target enrollment increased from 7 to 21
Target enrollment increased from 1310 to 1559
Eligibility criteria have been updated
Added 4 new sites: Miami, Florida, Lexington, Kentucky, Columbus, Ohio and 1 more
Added 1 new site: Seattle, Washington
Eligibility criteria have been updated
Added 1 new site: Sapporo, Japan
Added 12 new sites: Temuco, Chile, Valdivia, Chile, Santiago, Chile and 9 more
Added 1 new site: Seattle, Washington
Added 1 new site: Athens, Greece
Added 2 new sites: Pátrai, Greece, Taoyuan, Taiwan
Eligibility criteria have been updated
Added 2 new sites: Córdoba, Argentina, Riyadh, Saudi Arabia
Added 11 new sites: Birmingham, Alabama, Los Angeles, California, Baltimore, Maryland and 8 more
Added 1 new site: Spokane Valley, Washington
Added 1 new site: Lisbon, Portugal
Eligibility criteria have been updated
Added 6 new sites: Albany, New York, Houston, Texas, Seattle, Washington and 3 more
Target enrollment increased from 131 to 195
Eligibility criteria have been updated
Added 8 new sites: Birmingham, Alabama, Gainesville, Florida, Indianapolis, Indiana and 5 more
Added 7 new sites: Bullhead City, Arizona, Boulder, Colorado, St. Petersburg, Florida and 4 more
Added 1 new site: Frankfurt, Germany
Added 1 new site: Warsaw, Poland
Target enrollment decreased from 66 to 42
Eligibility criteria have been updated
Added 7 new sites: Grand Rapids, Michigan, Minneapolis, Minnesota, Minneapolis, Minnesota and 4 more
Added 1 new site: Tel Aviv, Israel
Added 7 new sites: Denver, Colorado, Washington D.C., District of Columbia, Kalamazoo, Michigan and 4 more
Added 9 new sites: Kansas City, Kansas, Grand Rapids, Michigan, Minneapolis, Minnesota and 6 more
Added 1 new site: New York, New York