Rare Disease Trial Updates: June 2026
In June 2026, Trial Friend tracked 466 rare disease clinical trial updates across 98 conditions, including 1 FDA-related actions and 71 trial status changes, alongside enrollment updates and new trial site openings sourced from ClinicalTrials.gov and FDA announcements.
This is a permanent monthly archive. For the latest updates, see the live current events feed.
Major Updates: FDA Actions, Status Changes & Results
The U.S. Food and Drug Administration today approved TREGZI, the first regulatory T (Treg) cell-based immunotherapy for improving chronic graft-versus-host disease (GVHD)-free survival in adult patients with blood cancers undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT).
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
Now recruiting (was Active Not Recruiting)
No longer enrolling new participants
Now recruiting (was Enrolling By Invitation)
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
Now recruiting (was Active Not Recruiting)
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
Now recruiting (was Active Not Recruiting)
No longer enrolling new participants
Now recruiting (was Active Not Recruiting)
No longer enrolling new participants
Now recruiting (was Enrolling By Invitation)
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
Now recruiting (was Active Not Recruiting)
No longer enrolling new participants
Now recruiting (was Active Not Recruiting)
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
Now recruiting (was Active Not Recruiting)
Status changed from Recruiting to Enrolling By Invitation
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
No longer enrolling new participants
Now recruiting (was Enrolling By Invitation)
No longer enrolling new participants
No longer enrolling new participants
Now recruiting (was Active Not Recruiting)
No longer enrolling new participants
Trial Site & Enrollment Activity
Added 1 new site: Maywood, Illinois
Added 21 new sites: Phoenix, Arizona, Little Rock, Arkansas, Los Angeles, California and 18 more
Eligibility criteria have been updated
Added 1 new site: Greenville, North Carolina
Added 13 new sites: Feldkirch, Austria, Brussels, Belgium, Bruges, Belgium and 10 more
Added 1 new site: Coon Rapids, Minnesota
Added 3 new sites: São Paulo, Brazil, Cork, Ireland, Mersin, Turkey (Türkiye)
Added 2 new sites: Chicago, Illinois, Salt Lake City, Utah
Eligibility criteria have been updated
Eligibility criteria have been updated
Added 2 new sites: Irvine, California, Durham, North Carolina
Eligibility criteria have been updated
Reduced from 5 to 2 sites
Eligibility criteria have been updated
Added 6 new sites: Tucson, Arizona, Sacramento, California, Boston, Massachusetts and 3 more
Added 5 new sites: Caen, France, Paris, France, Roma, Italy and 2 more
Added 4 new sites: Rochester, Minnesota, Ramat Gan, Israel, Ramat Gan, Israel and 1 more
Added 6 new sites: Berkeley Heights, New Jersey, Columbus, Ohio, Nantong, China and 3 more
Added 2 new sites: Indianapolis, Indiana, Pittsburgh, Pennsylvania
Added 1 new site: Genova, Italy
Added 2 new sites: Toulouse, France, Zaragoza, Spain
Eligibility criteria have been updated
Eligibility criteria have been updated
Reduced from 21 to 16 sites
Added 1 new site: Meldola, Italy
Added 6 new sites: Berkeley Heights, New Jersey, Columbus, Ohio, Nantong, China and 3 more
Added 1 new site: Duarte, California
Added 2 new sites: Copenhagen, Denmark, Bratislava, Slovakia
Target enrollment increased from 20 to 40
Eligibility criteria have been updated
Added 1 new site: Memphis, Tennessee
Eligibility criteria have been updated
Added 2 new sites: Philadelphia, Pennsylvania, Chiba, Japan
Added 3 new sites: Córdoba, Argentina, Bahia, Brazil, Chiba, Japan
Added 6 new sites: South Brisbane, Australia, Burnaby, Canada, Ulm, Germany and 3 more
Added 18 new sites: Phoenix, Arizona, Tampa, Florida, Worchester, Massachusetts and 15 more
Added 2 new sites: Capital Federal, Argentina, Braga, Portugal
Added 5 new sites: Columbus, Ohio, Choceň, Czechia, Erbach im Odenwald, Germany and 2 more
Reduced from 108 to 106 sites
Added 2 new sites: Columbus, Ohio, Beijing, China
Added 1 new site: Livingston, New Jersey
Eligibility criteria have been updated
Added 14 new sites: Richmond, Virginia, Milwaukee, Wisconsin, Porto Alegre, Brazil and 11 more
Added 2 new sites: Santa Rosa, California, East Brunswick, New Jersey
Target enrollment decreased from 154 to 27
Eligibility criteria have been updated
Added 69 new sites: Tampa, Florida, Atlanta, Georgia, Chicago, Illinois and 66 more
Eligibility criteria have been updated
Eligibility criteria have been updated
Added 1 new site: Paris, France
Added 3 new sites: São Paulo, Brazil, Cork, Ireland, Mersin, Turkey (Türkiye)
Added 1 new site: Chicago, Illinois
Added 1 new site: Boston, Massachusetts
Added 1 new site: Barcelona, Spain
Added 17 new sites: Iowa City, Iowa, Serra, Brazil, Botucatu, Brazil and 14 more
Target enrollment increased from 476 to 750
Added 2 new sites: Bogotá, Colombia, London, United Kingdom
Reduced from 267 to 246 sites
Target enrollment increased from 510 to 579
Eligibility criteria have been updated
Target enrollment increased from 200 to 250
Eligibility criteria have been updated
Added 13 new sites: Buenos Aires, Argentina, Buenos Aires, Argentina, Chermside, Australia and 10 more
Added 3 new sites: Los Angeles, California, Westmead, Australia, London, United Kingdom
Added 8 new sites: La Jolla, California, Chicago, Illinois, Fairway, Kansas and 5 more
Added 2 new sites: CABA, Argentina, Santiago, Chile
Eligibility criteria have been updated
Reduced from 24 to 21 sites
Added 3 new sites: Ludwigshafen, Germany, Arecibo, Puerto Rico, Santiago Compostela, Spain
Added 3 new sites: Columbus, Ohio, Wenzhou, China, Fuzhou, China
Added 3 new sites: Varna, Bulgaria, Varna, Bulgaria, Prague, Czechia
Added 4 new sites: Cuneo, Italy, Shibuya City, Japan, Riga, Latvia and 1 more
Reduced from 76 to 63 sites
Added 1 new site: London, United Kingdom
Added 10 new sites: Scottsdale, Arizona, Campbell, California, Torrance, California and 7 more
Added 3 new sites: Dijon, France, Debrecen, Hungary, Budapest, Hungary
Added 12 new sites: Créteil, France, Nice, France, Paris, France and 9 more
Added 1 new site: Colorado Springs, Colorado
Added 13 new sites: Los Angeles, California, Coral Gables, Florida, Coral Springs, Florida and 10 more
Added 3 new sites: Berkeley Heights, New Jersey, Nantong, China, Beijing, China
Added 2 new sites: Copenhagen, Denmark, Bratislava, Slovakia
Added 6 new sites: Dresden, Germany, Dresden, Germany, Essen, Germany and 3 more
Reduced from 76 to 63 sites
Eligibility criteria have been updated
Added 1 new site: St Louis, Missouri
Eligibility criteria have been updated
Added 1 new site: Cordova, Tennessee
Eligibility criteria have been updated
Added 4 new sites: Jerusalem, Israel, Tel Aviv, Israel, Santiago de Compostela, Spain and 1 more
Target enrollment decreased from 50 to 32
Added 7 new sites: Wuhan, China, Nanjing, China, Suzhou, China and 4 more
Eligibility criteria have been updated
Added 2 new sites: New York, New York, Cincinnati, Ohio
Added 1 new site: Umeå, Sweden
Target enrollment increased from 42 to 54
Added 2 new sites: Caulfield South, Australia, Nedlands, Australia
Eligibility criteria have been updated
Added 8 new sites: San Francisco, California, Chicago, Illinois, St Louis, Missouri and 5 more
Added 1 new site: New York, New York
Added 7 new sites: Wuhan, China, Nanjing, China, Suzhou, China and 4 more
Added 2 new sites: Toulouse, France, Zaragoza, Spain
Added 1 new site: Salt Lake City, Utah
Reduced from 130 to 127 sites
Added 1 new site: Belo Horizonte, Brazil
Added 5 new sites: Palo Alto, California, St. Petersburg, Florida, Minneapolis, Minnesota and 2 more
Added 2 new sites: Copenhagen, Denmark, Bratislava, Slovakia
Added 1 new site: Lahore, Pakistan
Added 4 new sites: Cali, Colombia, Al Qaţīf, Saudi Arabia, Riyadh, Saudi Arabia and 1 more
Added 5 new sites: Hobart, Australia, Le Kremlin-Bicêtre, France, Seoul, South Korea and 2 more
Added 1 new site: Porto Alegre, Brazil
Reduced from 5 to 3 sites
Target enrollment decreased from 20 to 9
Added 2 new sites: Copenhagen, Denmark, Bratislava, Slovakia
Added 1 new site: Belo Horizonte, Brazil
Added 14 new sites: San Francisco, California, Jacksonville, Florida, Melbourne, Australia and 11 more
Added 3 new sites: Stuttgart, Germany, Nuremberg, Germany, Freiburg im Breisgau, Germany
Added 1 new site: Tours, France
Added 3 new sites: Rome, Italy, Seoul, South Korea, Izmir, Turkey (Türkiye)
Added 1 new site: London, United Kingdom
Added 1 new site: Seoul, South Korea
Added 5 new sites: Palo Alto, California, St. Petersburg, Florida, Minneapolis, Minnesota and 2 more
Added 1 new site: Lahore, Pakistan
Added 1 new site: Lahore, Pakistan
Added 1 new site: Lahore, Pakistan
Added 1 new site: Lahore, Pakistan
Reduced from 174 to 144 sites
Eligibility criteria have been updated
Added 43 new sites: Gilbert, Arizona, Duarte, California, Santa Rosa, California and 40 more
Eligibility criteria have been updated
Added 6 new sites: Scottsdale, Arizona, O'Fallon, Illinois, Columbia, Missouri and 3 more
Added 1 new site: Schaumburg, Illinois
Added 4 new sites: Paris, France, Beelitz, Germany, Elche, Spain and 1 more
Added 1 new site: Sendai, Japan
Reduced from 109 to 89 sites
Target enrollment decreased from 700 to 489
Added 2 new sites: Roeland Park, Kansas, Salem, Virginia
Added 1 new site: Los Angeles, California
Added 2 new sites: Birmingham, Alabama, St Louis, Missouri
Eligibility criteria have been updated
Added 4 new sites: St Leonards, Australia, Guangzhou, China, Wuhan, China and 1 more
Eligibility criteria have been updated
Added 6 new sites: Hadera, Israel, Epsom, New Zealand, Papatoetoe, New Zealand and 3 more
Eligibility criteria have been updated
Added 1 new site: Pittsburgh, Pennsylvania
Eligibility criteria have been updated
Added 6 new sites: Aomori, Japan, Kagoshima, Japan, Kitakyusyu-shi, Fukuoka, Japan and 3 more
Added 15 new sites: Fukui, Japan, Fukushima, Japan, Hyōgo, Japan and 12 more
Added 6 new sites: Aomori, Japan, Kagoshima, Japan, Kitakyusyu-shi, Fukuoka, Japan and 3 more
Added 15 new sites: Fukui, Japan, Fukushima, Japan, Hyōgo, Japan and 12 more
Added 3 new sites: Metairie, Louisiana, Worcester, Massachusetts, Ottawa, Canada
Eligibility criteria have been updated
Added 1 new site: Tbilisi, Georgia
Added 6 new sites: New York, New York, New York, New York, Lyon, France and 3 more
Added 3 new sites: Bakersfield, California, Bellaire, Texas, Vancouver, Canada
Added 30 new sites: Los Angeles, California, Los Angeles, California, San Francisco, California and 27 more
Added 16 new sites: Birmingham, Alabama, Orange City, Florida, Toledo, Ohio and 13 more
Eligibility criteria have been updated
Added 1 new site: Bethesda, Maryland
Added 1 new site: San Francisco, California
Added 1 new site: Palo Alto, California
Added 5 new sites: Antwerp, Belgium, Porto Alegre, Brazil, Roma, Italy and 2 more
Added 3 new sites: Philadelphia, Pennsylvania, Massa, Italy, London, United Kingdom
Added 2 new sites: Guangzhou, China, Taichung, Taiwan
Added 2 new sites: Messina, Italy, Krakow, Poland
Added 2 new sites: Nedlands, Australia, Brussels, Belgium
Added 2 new sites: Bunkyo-Ku, Japan, Konya, Turkey (Türkiye)
Added 5 new sites: Centennial, Colorado, Miami Lakes, Florida, Lille, France and 2 more
Added 2 new sites: Paris, France, Salford, United Kingdom
Added 4 new sites: Miami Lakes, Florida, Belo Horizonte, Brazil, Bunkyo-Ku, Japan and 1 more
Added 5 new sites: Birmingham, Alabama, Rosario, Argentina, Lille, France and 2 more
Target enrollment increased from 241 to 296
Added 12 new sites: Aurora, Colorado, Chicago, Illinois, Rochester, Minnesota and 9 more
Added 9 new sites: Liverpool, Australia, Rio de Janeiro, Brazil, Vancouver, Canada and 6 more
Eligibility criteria have been updated
Added 1 new site: Ann Arbor, Michigan
Added 15 new sites: Tampa, Florida, Baltimore, Maryland, St Louis, Missouri and 12 more
Added 3 new sites: Minneapolis, Minnesota, Saint Paul, Minnesota, Monroe, North Carolina
Added 2 new sites: Mersin, Turkey (Türkiye), London, United Kingdom
Added 1 new site: Philadelphia, Pennsylvania
Eligibility criteria have been updated
Added 2 new sites: Mersin, Turkey (Türkiye), London, United Kingdom
Eligibility criteria have been updated
Added 3 new sites: Tampa, Florida, Regensburg, Germany, Otwock, Poland
Added 1 new site: Santa Barbara, California
Reduced from 35 to 33 sites
Added 2 new sites: Capital Federal, Argentina, Pune, India
Added 2 new sites: Denver, Colorado, Philadelphia, Pennsylvania
Added 2 new sites: Glendale, California, San Diego, California
Added 1 new site: Atlanta, Georgia
Added 4 new sites: Macon, Georgia, Dallas, Texas, San Antonio, Texas and 1 more
Added 1 new site: Huntersville, North Carolina
Added 2 new sites: Capital Federal, Argentina, Pune, India
Added 2 new sites: Denver, Colorado, Philadelphia, Pennsylvania
Eligibility criteria have been updated
Added 1 new site: Winston-Salem, North Carolina
Target enrollment decreased from 180 to 82
Target enrollment decreased from 40 to 10
Added 3 new sites: Detroit, Michigan, Durham, North Carolina, Milan, Italy
Added 2 new sites: O'Fallon, Illinois, Sherman, Texas
Added 2 new sites: Detroit, Michigan, Durham, North Carolina
Added 1 new site: Palo Alto, California
Eligibility criteria have been updated
Added 1 new site: Kassel, Germany
Added 3 new sites: Nashville, Tennessee, Caen, France, Barakaldo, Spain
Added 2 new sites: Athens, Greece, Athens, Greece
Target enrollment decreased from 444 to 152
Expanded from 127 to 129 sites
Eligibility criteria have been updated
Eligibility criteria have been updated
Reduced from 178 to 151 sites
Added 2 new sites: West Valley City, Utah, Seattle, Washington
Eligibility criteria have been updated
Expanded from 11 to 13 sites
Added 1 new site: Kyoto, Japan
Added 5 new sites: Cleveland, Ohio, London, Canada, Xi'an, China and 2 more
Reduced from 12 to 9 sites
Added 1 new site: Herston, Australia
Added 4 new sites: Liverpool, Australia, Wŏnju, South Korea, Barcelona, Spain and 1 more
Added 4 new sites: Melbourne, Australia, Be’er Ya‘aqov, Israel, Petah Tikva, Israel and 1 more
Eligibility criteria have been updated
Added 9 new sites: Cleveland, Ohio, Tel Aviv, Israel, Seoul, South Korea and 6 more
Added 2 new sites: Chicago, Illinois, Hackensack, New Jersey
Added 1 new site: Barcelona, Spain
Target enrollment decreased from 44 to 24
Added 1 new site: Chicago, Illinois
Added 1 new site: Dublin, Ireland
Eligibility criteria have been updated
Added 5 new sites: Zagreb, Croatia, Brno, Czechia, Helsinki, Finland and 2 more
Added 3 new sites: Torino, Italy, Porto, Portugal, Malmö, Sweden
Added 3 new sites: Torino, Italy, Porto, Portugal, Malmö, Sweden
Added 4 new sites: Lille, France, Coimbra, Portugal, Lisbon, Portugal and 1 more
Added 2 new sites: Nantes, France, Nantes, France
Moved from Phase 1 to Phase 2
Added 1 new site: Poitiers, France
Target enrollment increased from 20 to 50
Added 2 new sites: Ramat Gan, Israel, Nagoya, Japan
Added 9 new sites: Belo Horizonte, Brazil, São Paulo, Brazil, São Paulo, Brazil and 6 more
Added 1 new site: Southport, Australia
Added 1 new site: Sunderland, United Kingdom
Target enrollment decreased from 1000 to 500
Eligibility criteria have been updated
Eligibility criteria have been updated
Added 5 new sites: Portland, Oregon, Fortaleza, Brazil, Belo Horizonte, Brazil and 2 more
Added 7 new sites: Redding, California, Orlando, Florida, Riverview, Florida and 4 more
Added 2 new sites: Atlanta, Georgia, São Paulo, Brazil
Added 2 new sites: Birmingham, Alabama, St Louis, Missouri
Added 1 new site: Bentonville, Arkansas
Added 2 new sites: Denver, Colorado, Philadelphia, Pennsylvania
Added 1 new site: Nashville, Tennessee
Added 2 new sites: Capital Federal, Argentina, Pune, India
Added 5 new sites: Candiolo, Italy, Milan, Italy, Padova, Italy and 2 more
Added 1 new site: Palo Alto, California
Added 2 new sites: Rosario, Argentina, Orbassano, Italy
Added 3 new sites: Xuzhou, China, Xian, China, Chongqing, China
Added 1 new site: Atlanta, Georgia
Added 1 new site: Ankara, Turkey (Türkiye)
Added 11 new sites: Florida City, Florida, Atlanta, Georgia, Philadelphia, Pennsylvania and 8 more
Added 3 new sites: La Jolla, California, Burlington, Massachusetts, Houston, Texas
Added 2 new sites: Alicante, Spain, Barcelona, Spain
Added 2 new sites: Edmonton, Canada, Ottawa, Canada
Added 2 new sites: Chicago, Illinois, Shanghai, China
Added 2 new sites: Minneapolis, Minnesota, Saint Paul, Minnesota
Added 1 new site: Boston, Massachusetts
Added 3 new sites: Louisville, Kentucky, ClermontFerrand, France, Newmarket, United Kingdom
Eligibility criteria have been updated
Added 1 new site: Dallas, Texas
Added 1 new site: Cincinnati, Ohio
Added 1 new site: Bethesda, Maryland
Eligibility criteria have been updated
Added 1 new site: Barranquilla, Colombia
Added 1 new site: Dresden, Germany
Eligibility criteria have been updated
Target enrollment increased from 116 to 166
Eligibility criteria have been updated
Eligibility criteria have been updated
Eligibility criteria have been updated
Added 3 new sites: Lodz, Poland, Hat Yai, Thailand, Khon Kaen, Thailand
Eligibility criteria have been updated
Added 1 new site: Kurashiki, Japan
Added 4 new sites: Clayton, Australia, Tianjin, China, Suwon, South Korea and 1 more
Added 3 new sites: Hefei, China, Nantong, China, Jinan, China
Eligibility criteria have been updated
Target enrollment increased from 60 to 76
Added 8 new sites: Los Angeles, California, Boulder, Colorado, Miami, Florida and 5 more
Eligibility criteria have been updated
Target enrollment increased from 500 to 1000
Eligibility criteria have been updated
Added 1 new site: Columbia, Missouri
Added 1 new site: Maastricht, Netherlands
Eligibility criteria have been updated
Added 4 new sites: Clayton, Australia, Tianjin, China, Suwon, South Korea and 1 more
Added 1 new site: Kurashiki, Japan
Added 2 new sites: Cardiff, United Kingdom, Glasgow, United Kingdom
Added 2 new sites: Nedlands, Australia, Barcelona, Spain
Target enrollment decreased from 255 to 155
Eligibility criteria have been updated
Added 2 new sites: New York, New York, Seattle, Washington
Eligibility criteria have been updated
Added 2 new sites: Fullerton, California, Indianapolis, Indiana
Added 3 new sites: Tampa, Florida, Columbus, Ohio, San Antonio, Texas
Added 27 new sites: Sacramento, California, Washington D.C., District of Columbia, Maitland, Florida and 24 more
Added 5 new sites: Tampa, Florida, Columbus, Ohio, Chattanooga, Tennessee and 2 more
Added 1 new site: Madrid, Spain
Added 3 new sites: Marburg, Germany, Sagamihara, Japan, Pamplona, Spain
Eligibility criteria have been updated
Added 4 new sites: Phoenix, Arizona, Fullerton, California, West Hollywood, California and 1 more
Added 2 new sites: Brno, Czechia, Ulm, Germany
Added 7 new sites: Seattle, Washington, Leuven, Belgium, Bonheiden, Belgium and 4 more
Added 1 new site: Miami, Florida
Target enrollment decreased from 240 to 20
Added 1 new site: Philadelphia, Pennsylvania
Added 1 new site: Durham, North Carolina
Eligibility criteria have been updated
Target enrollment decreased from 240 to 20
Added 2 new sites: Nagoya, Japan, Kobe, Japan
Added 5 new sites: Recife, Brazil, Shijiazhuang, China, Dublin, Ireland and 2 more
Added 2 new sites: Belo Horizonte, Brazil, São Paulo, Brazil
Target enrollment decreased from 50 to 26
Added 3 new sites: Shelby, Michigan, Houston, Texas, Salt Lake City, Utah
Reduced from 161 to 155 sites
Target enrollment decreased from 540 to 448
Added 2 new sites: Toyoake, Japan, Riyadh, Saudi Arabia
Added 1 new site: London, United Kingdom
Target enrollment increased from 12 to 24
Eligibility criteria have been updated
Added 3 new sites: Caba, Argentina, Kogarah, Australia, Kuantan, Malaysia
Eligibility criteria have been updated
Added 7 new sites: Westmead, Australia, Vancouver, Canada, Ramat Gan, Israel and 4 more
Added 5 new sites: Denver, Colorado, Weston, Florida, Chapel Hill, North Carolina and 2 more
Added 5 new sites: CABA, Argentina, CABA, Argentina, CABA, Argentina and 2 more
Added 2 new sites: Lyon, France, Montpellier, France
Added 18 new sites: Colorado Springs, Colorado, Wheaton, Maryland, Santo André, Brazil and 15 more
Added 4 new sites: Miami, Florida, Louisville, Kentucky, Linz, Austria and 1 more
Added 6 new sites: Sofia, Bulgaria, Bonn, Germany, Milan, Italy and 3 more
Added 4 new sites: Los Angeles, California, San Dimas, California, Arvada, Colorado and 1 more
Added 1 new site: Hamilton, Pennsylvania
Eligibility criteria have been updated
Added 4 new sites: St Louis, Missouri, San Antonio, Texas, Chambéry, France and 1 more
Added 3 new sites: Greenville, North Carolina, Greenville, North Carolina, Fatih, Turkey (Türkiye)
Added 3 new sites: Santa Barbara, California, Prague, Czechia, Créteil, France
Added 25 new sites: Gilbert, Arizona, Huntington Beach, California, Oxnard, California and 22 more
Added 1 new site: Genova, Italy
Eligibility criteria have been updated
Eligibility criteria have been updated
Added 1 new site: Kurashiki, Japan
Added 6 new sites: Sydney, Australia, Sydney, Australia, Adelaide, Australia and 3 more
Added 4 new sites: Clayton, Australia, Tianjin, China, Suwon, South Korea and 1 more
Added 8 new sites: Los Angeles, California, Minneapolis, Minnesota, Milwaukee, Wisconsin and 5 more
Added 3 new sites: Chicago, Illinois, Bari, Italy, Catania, Italy
Added 1 new site: Shanghai, China
Added 4 new sites: Essen, Germany, Giessen, Germany, Mainz, Germany and 1 more
Added 1 new site: Philadelphia, Pennsylvania
Added 3 new sites: Little Rock, Arkansas, Flower Mound, Texas, Norfolk, Virginia
Target enrollment increased from 1500 to 2000
Added 10 new sites: San Diego, California, Jacksonville, Florida, Chicago, Illinois and 7 more
Added 1 new site: Birmingham, Alabama
Eligibility criteria have been updated
Added 1 new site: Boston, Massachusetts
Eligibility criteria have been updated
Added 1 new site: Manchester, United Kingdom
Eligibility criteria have been updated
Target enrollment decreased from 59 to 4
Added 2 new sites: Athens, Greece, Coimbra, Portugal
Target enrollment increased from 100 to 230
Eligibility criteria have been updated
Added 5 new sites: Fukuoka, Japan, Yokohama, Japan, Tosa-gun, Japan and 2 more
Added 3 new sites: Little Rock, Arkansas, Flower Mound, Texas, Norfolk, Virginia
Target enrollment decreased from 35 to 15
Target enrollment decreased from 145 to 13
Added 1 new site: Seville, Spain
Added 1 new site: Houston, Texas
Added 6 new sites: Los Angeles, California, San Francisco, California, St Louis, Missouri and 3 more
Added 7 new sites: Chicago, Illinois, Baltimore, Maryland, San Antonio, Texas and 4 more
Added 1 new site: Houston, Texas
Added 2 new sites: Hiroshima, Japan, Nagano, Japan
Added 7 new sites: East Lansing, Michigan, Las Vegas, Nevada, Narita, Japan and 4 more
Added 1 new site: Sejong, South Korea
Added 1 new site: Phoenix, Arizona
Added 2 new sites: Sacramento, California, Portland, Oregon
Added 1 new site: Boston, Massachusetts
Target enrollment increased from 22 to 27
Eligibility criteria have been updated
Added 2 new sites: Auchenflower, Australia, Pavia, Italy
Added 3 new sites: Scottsdale, Arizona, Edmonton, Canada, Giessen, Germany
Added 3 new sites: Riga, Latvia, Namdong-gu, South Korea, Seoul, South Korea
Added 3 new sites: Leipzig, Germany, Berlin, Germany, Stadtroda, Germany
Added 1 new site: Chandler, Arizona
Added 3 new sites: Birmingham, Alabama, Padova, Italy, Chiayi City, Taiwan
Added 3 new sites: Fitzroy, Australia, Linz, Austria, Montreal, Canada
Added 1 new site: Cleveland, Ohio
Added 1 new site: Nashville, Tennessee
Added 1 new site: Szczecin, Poland
Added 2 new sites: Chicago, Illinois, Lexington, Massachusetts
Added 2 new sites: Ribeirão Preto, Brazil, Istanbul, Turkey (Türkiye)