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All 168 Amyotrophic Lateral Sclerosis trials and their US sites
Enter your ZIP code above to sort them by how far their nearest open site is from you.
- ASSESS ALL ALS StudyMost sites in California, Pennsylvania and FloridaRecruitingAges 18+St. Joseph's Hospital and Medical Center, Phoenix34US sites
26 states - ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)Most sites in California, Maryland and New YorkRecruitingAges 18+Mayo Clinic24US sites
19 states - Pridopidine Phase 3 Study to Evaluate Efficacy and Safety in ALSMost sites in Florida, Texas and WashingtonRecruitingPhase 3Ages 18-80Prilenia18US sites
15 states - Usnoflast Neuromuscular Investigation for Treatment Efficacy in Amyotrophic Lateral SclerosisMost sites in California, Texas and ConnecticutRecruitingPhase 2Ages 18+Zydus Therapeutics15US sites
12 states - ALS/MND Natural History Study Data RepositoryMost sites in Pennsylvania, California and MichiganRecruitingAges 18-90Massachusetts General Hospital14US sites
10 states - AMX0114 in Adult Participants With Amyotrophic Lateral SclerosisMost sites in Florida, California and District of ColumbiaRecruitingPhase 1Ages 18+Amylyx Pharmaceuticals10US sites
8 states - Clinical Procedures to Support Research in ALSMost sites in California, North Carolina and FloridaRecruitingAges 18+University of Miami10US sites
7 states - Target ALS Biomarker Study; Longitudinal Biofluids, Clinical Measures, and At Home MeasuresMost sites in Arizona, California and District of ColumbiaRecruitingAges 18+Target ALS Foundation10US sites
10 states - A Study to Investigate the Safety and Pharmacodynamics of a Single Intrathecal Injection (IT) of INS1202 in Participants With Amyotrophic Lateral Sclerosis (ALS)Most sites in California, Arizona and MarylandRecruitingPhase 1Ages 18-79Insmed Gene Therapy9US sites
8 states - Do Video Recordings of Multidisciplinary Clinics Improve Quality of Life for People With ALS and Their Caregivers?Most sites in Pennsylvania, Arizona and FloridaRecruitingAges 18+Trustees of Dartmouth College7US sites
6 states - A Study of Ranolazine in ALSMost sites in Kansas, California and FloridaRecruitingPhase 2Ages 18+Swathy Chandrashekhar, MBBS6US sites
5 states - BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With TetraplegiaMost sites in California, Georgia and MassachusettsRecruitingAges 18-80Leigh R. Hochberg, MD, PhD.6US sites
5 states - Efficacy and Safety of Masitinib Versus Placebo in the Treatment of ALS PatientsMost sites in Alabama, California and KentuckyRecruitingPhase 3Ages 18-81AB Science6US sites
6 states - EIM Via the Myolex mScan as an ALS BiomarkerMost sites in Massachusetts, Arizona and MichiganRecruitingAges 18+Beth Israel Deaconess Medical Center6US sites
5 states - Study is to Assess the Safety and Tolerability of VTx-002 in Participants With ALSMost sites in Arizona, California and FloridaRecruitingPhase 1/2Ages 18+Vector Y Therapeutics6US sites
6 states - PHENOGENE-1A (Cromolyn) Treatment in Patients With Mild to Moderate ALSMost sites in California, Arizona and FloridaRecruitingPhase 2Ages 18-75PhenoNet5US sites
4 states - Healey ALS MyMatch Common Screening ProtocolMost sites in Florida, Illinois and MassachusettsRecruitingAges 18+Massachusetts General Hospital4US sites
4 states - A Study to Learn About the Safety of BIIB147 and Its Effects in Adults With Amyotrophic Lateral Sclerosis (ALS)Most sites in Arizona, Missouri and TexasRecruitingPhase 1/2Ages 18+Biogen3US sites
3 states - Connect-One: Early Feasibility Study of Connexus® Brain-Computer Interface (BCI)Most sites in California, Massachusetts and MichiganRecruitingAges 22-75Paradromics3US sites
3 states - Intermuscular Coherence as a Biomarker for ALSMost sites in Florida, Massachusetts and MissouriRecruitingAges 20-90University of Chicago3US sites
3 states
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Who runs the Amyotrophic Lateral Sclerosis trials in the US, and what stage they are in
Of the 85 Amyotrophic Lateral Sclerosis trials with a US site, 4 are in Phase 3, the last stage before a company can ask the FDA for approval. Earlier Phase 1 or 2 tests of safety and dosing make up 22 of them. The remaining 59 have no drug phase, such as studies that follow people over time or test a device or a way of giving care. Companies run 26 of them, and universities, hospitals, foundations and government groups run 59. The sponsors with the most are Johns Hopkins University (4), Cognixion (3) and Duke University (3). The most recently listed one first appeared on ClinicalTrials.gov on November 12, 2026.
Amyotrophic Lateral Sclerosis trials in the US, state by state
Of the 85 Amyotrophic Lateral Sclerosis trials with a US site, 2 accept children under 18. Their open sites are in Maryland and New York. A trial counts once in each state where it has an open site, and some trials accept both children and adults.
Show the other 23 states
US hospitals running the most Amyotrophic Lateral Sclerosis trials
Centers that run trials for a rare condition often see more people with it than most clinics do, so this list can also help you find doctors who know Amyotrophic Lateral Sclerosis.
- Massachusetts General HospitalBoston, Massachusetts14 trials
- Northwestern UniversityChicago, Illinois7 trials
- Barrow Neurological InstitutePhoenix, Arizona6 trials
- University of MiamiMiami, Florida5 trials
- University of MinnesotaMinneapolis, Minnesota5 trials
- University of PennsylvaniaPhiladelphia, Pennsylvania5 trials
- Columbia UniversityNew York, New York4 trials
- Mayo ClinicJacksonville, Florida4 trials
- Nova Southeastern UniversityDavie, Florida4 trials
- University of MichiganAnn Arbor, Michigan4 trials
Help getting to an Amyotrophic Lateral Sclerosis trial far from home
Ask the study team whether the trial pays back travel, parking and hotel costs, because many sponsors do. The FDA's guidance on paying research volunteers says paying back these costs does not count as pressuring someone to join.
These nonprofits also help patients reach care, and each one sets its own rules.
- Mercy Medical Angels
- Pays for gas cards, ground rides and airline tickets anywhere in the US, and it lists clinical trials as a reason to travel. Household income at or below 300% of the federal poverty guidelines, and usually a trip of 50 miles or more each way.
- Air Charity Network
- Volunteer pilots in all 50 states fly patients for free in small private planes, and members also fly people taking part in clinical trials. You must be able to walk and sit upright for the flight, show financial need and have a backup plan if weather cancels it.
- Ronald McDonald House
- Gives families a room near the hospital while a child gets care, through 394 House programs around the world. Families of a sick child, with rules set by each local chapter.
- Healthcare Hospitality Network
- Keeps a map of hospitality houses near hospitals, and most member houses charge little or nothing to patients and families. Each house sets its own rules, so check with the house near your study site.
Program details were checked on each program's website on October 24, 2026.
Questions about finding an Amyotrophic Lateral Sclerosis trial near you
Are there Amyotrophic Lateral Sclerosis clinical trials near me?
As of November 13, 2026, 168 Amyotrophic Lateral Sclerosis clinical trials are recruiting now and 53 are not yet recruiting. In the US, 85 of them have at least 1 open site, across 32 states and Washington, DC. Enter your ZIP code on this page to rank every one of them by the distance to its closest open site, with the sites shown on a map.
Which states have Amyotrophic Lateral Sclerosis clinical trial sites?
Recruiting Amyotrophic Lateral Sclerosis trials list open sites in 32 states and Washington, DC. Florida, Massachusetts and California have the most, and the table on this page lists every state.
Are there Amyotrophic Lateral Sclerosis trials for children near me?
Of the 85 Amyotrophic Lateral Sclerosis trials with a US site, 2 accept children under 18. Their open sites are in Maryland and New York. Each trial sets its own age limits, so check the ages listed on a trial before you contact it.
Who pays for travel to an Amyotrophic Lateral Sclerosis clinical trial?
Many trial sponsors pay back travel, parking and hotel costs, so ask the study team before you rule out a far-away site. The FDA's guidance says paying back these costs does not count as pressuring someone to join. Charities such as Mercy Medical Angels and Air Charity Network can also help with rides and flights.
What if there is no Amyotrophic Lateral Sclerosis trial near me?
Some trials send staff to your home or use a local lab, so fewer visits happen at the study site. You can also sign up on this page to get an email when an Amyotrophic Lateral Sclerosis trial opens a new site or changes status.
How is the distance to a trial site measured?
Distances are straight-line miles from the center of your ZIP code to each study site's listed location, not driving distance. Your browser looks up the ZIP code's coordinates with a free map service, Zippopotam.us, and the ZIP code is never sent to or stored by Trial Friend.
FDA-approved for Amyotrophic Lateral Sclerosis: Qalsody (tofersen), Radicava (edaravone), Rilutek (riluzole).
Clinical trials near you for related conditions
Source: ClinicalTrials.gov, trials with status Recruiting or Not yet recruiting. Refreshed every 6 hours; counts as of November 13, 2026. Sites that ClinicalTrials.gov lists as closed or withdrawn are left out. Children means the trial's age group includes people under 18.