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All 10 Urea Cycle Disorders trials and their US sites
Enter your ZIP code above to sort them by how far their nearest open site is from you.
- Hepatic Histopathology in Urea Cycle DisordersMost sites in District of Columbia and TexasRecruitingBaylor College of Medicine2US sites
2 states - Long-term Follow-up (LTFU) Study of Participants in Any iECURE Protocol Using an Investigational Product (IP)Most sites in Colorado and New YorkRecruitingAges 7 Months-15 MonthsiECURE2US sites
2 states - A Study to Evaluate the Pharmacodynamics and Safety of ARCT-810 in Participants With OTCDOnly in MarylandRecruitingPhase 2Ages 12+Arcturus Therapeutics1US site
- At Home Ammonia Monitoring of Inborn Errors of Ammonia MetabolismOnly in OregonRecruitingAges 12+Sequitur Health1US site
- Functional Evaluation in Patients With Urea Cycle Disorders (UCD) During a Driving TaskOnly in TennesseeRecruitingAges 16-40St. Jude Children's Research Hospital1US site
- Study of LNP.UCD.ABE in Patients With Urea Cycle DisordersOnly in PennsylvaniaRecruitingPhase 1/2Ages 24 Hours-5Rebecca Ahrens-Nicklas1US site
- Systemic Biomarkers of Brain Injury From HyperammonemiaOnly in District of ColumbiaRecruitingAges 7-18Children's National Research Institute1US site
- A Clinical Study of Glycerol Phenylbutyrate in Chinese Patients With Urea Cycle DisordersRecruitingAges 0-18Tongji HospitalNo US site yet
- Phase 1/2 Study of KRRO-121 in Healthy Volunteers and Patients With UCDRecruitingPhase 1/2Ages 18-65Korro BioNo US site yet
- Ureagenesis Analysis in Healthy Subjects and in Urea Cycle Disorder PatientsRecruitingUniversity Children's Hospital, ZurichNo US site yet
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Who runs the Urea Cycle Disorders trials in the US, and what stage they are in
None of the 7 Urea Cycle Disorders trials with a US site is in Phase 3, the last stage before a company can ask the FDA for approval. Earlier Phase 1 or 2 tests of safety and dosing make up 2 of them. The remaining 5 have no drug phase, such as studies that follow people over time or test a device or a way of giving care. Companies run 3 of them, and universities, hospitals, foundations and government groups run 4. The most recently listed one first appeared on ClinicalTrials.gov on July 14, 2026.
Urea Cycle Disorders trials in the US, state by state
All 7 Urea Cycle Disorders trials with a US site accept children under 18. Their open sites are in 7 states and Washington, DC, most often District of Columbia, Colorado and Maryland. A trial counts once in each state where it has an open site, and some trials accept both children and adults.
US hospitals running the most Urea Cycle Disorders trials
Centers that run trials for a rare condition often see more people with it than most clinics do, so this list can also help you find doctors who know Urea Cycle Disorders.
- Baylor College of MedicineHouston, Texas1 trial
- Children's Hospital of Colorado, Anshutz Medical CampusAurora, Colorado1 trial
- Children's Hospital of PhiladelphiaPhiladelphia, Pennsylvania1 trial
- Children's National Medical CenterWashington D.C., District of Columbia1 trial
- Children's National Research InstituteWashington D.C., District of Columbia1 trial
- Icahn School of Medicine at Mount SinaiNew York, New York1 trial
- Oregon Health & Science UniversityPortland, Oregon1 trial
- St. Jude Children's Research HospitalMemphis, Tennessee1 trial
- Uncommon CuresChevy Chase, Maryland1 trial
Help getting to an Urea Cycle Disorders trial far from home
Ask the study team whether the trial pays back travel, parking and hotel costs, because many sponsors do. The FDA's guidance on paying research volunteers says paying back these costs does not count as pressuring someone to join.
These nonprofits also help patients reach care, and each one sets its own rules.
- Mercy Medical Angels
- Pays for gas cards, ground rides and airline tickets anywhere in the US, and it lists clinical trials as a reason to travel. Household income at or below 300% of the federal poverty guidelines, and usually a trip of 50 miles or more each way.
- Air Charity Network
- Volunteer pilots in all 50 states fly patients for free in small private planes, and members also fly people taking part in clinical trials. You must be able to walk and sit upright for the flight, show financial need and have a backup plan if weather cancels it.
- Ronald McDonald House
- Gives families a room near the hospital while a child gets care, through 394 House programs around the world. Families of a sick child, with rules set by each local chapter.
- Healthcare Hospitality Network
- Keeps a map of hospitality houses near hospitals, and most member houses charge little or nothing to patients and families. Each house sets its own rules, so check with the house near your study site.
Program details were checked on each program's website on October 24, 2026.
Questions about finding an Urea Cycle Disorders trial near you
Are there Urea Cycle Disorders clinical trials near me?
As of November 13, 2026, 10 Urea Cycle Disorders clinical trials are recruiting now and 1 is not yet recruiting. In the US, 7 of them have at least 1 open site, across 7 states and Washington, DC. Enter your ZIP code on this page to rank every one of them by the distance to its closest open site, with the sites shown on a map.
Which states have Urea Cycle Disorders clinical trial sites?
Recruiting Urea Cycle Disorders trials list open sites in Colorado, District of Columbia, Maryland, New York, Oregon, Pennsylvania, Tennessee and Texas.
Are there Urea Cycle Disorders trials for children near me?
All 7 Urea Cycle Disorders trials with a US site accept children under 18. Their open sites are in 7 states and Washington, DC, most often District of Columbia, Colorado and Maryland. Each trial sets its own age limits, so check the ages listed on a trial before you contact it.
Who pays for travel to an Urea Cycle Disorders clinical trial?
Many trial sponsors pay back travel, parking and hotel costs, so ask the study team before you rule out a far-away site. The FDA's guidance says paying back these costs does not count as pressuring someone to join. Charities such as Mercy Medical Angels and Air Charity Network can also help with rides and flights.
What if there is no Urea Cycle Disorders trial near me?
Some trials send staff to your home or use a local lab, so fewer visits happen at the study site. You can also sign up on this page to get an email when an Urea Cycle Disorders trial opens a new site or changes status.
How is the distance to a trial site measured?
Distances are straight-line miles from the center of your ZIP code to each study site's listed location, not driving distance. Your browser looks up the ZIP code's coordinates with a free map service, Zippopotam.us, and the ZIP code is never sent to or stored by Trial Friend.
FDA-approved for Urea Cycle Disorders: Carbaglu (carglumic acid), Glycerol Phenylbutyrate (glycerol phenylbutyrate oral), Pheburane (sodium phenylbutyrate), Sodium phenylacetate and Sodium benzoate.
Clinical trials near you for related conditions
Source: ClinicalTrials.gov, trials with status Recruiting or Not yet recruiting. Refreshed every 6 hours; counts as of November 13, 2026. Sites that ClinicalTrials.gov lists as closed or withdrawn are left out. Children means the trial's age group includes people under 18.