Also on Trial Friend:Focal Epilepsy pageMatch Me
All 42 Focal Epilepsy trials and their US sites
Enter your ZIP code above to sort them by how far their nearest open site is from you.
- RENAISSANCE 2: SPN-817 Phase 2, Double-Blind, Placebo-Controlled Study in Adults With Focal Onset SeizuresMost sites in Florida, Arizona and CaliforniaRecruitingPhase 2Ages 18-70Supernus Pharmaceuticals37US sites
18 states - Study of NRTX-1001 Neural Cell Therapy in Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy (EPIC (EPIlepsy Cell Therapy))Most sites in California, New York and North CarolinaRecruitingPhase 3Ages 18-75Neurona Therapeutics36US sites
22 states - Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Focal Seizures FOCUS-1Most sites in California, New Jersey and New YorkRecruitingPhase 3Ages 18-75Rapport Therapeutics17US sites
14 states - A Randomized Study of XEN1101 Versus Placebo in Focal-Onset Seizures (X-TOLE3)Most sites in California, Florida and OhioRecruitingPhase 3Ages 18+Xenon Pharmaceuticals15US sites
12 states - Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Focal SeizuresMost sites in Florida, Texas and AlabamaRecruitingPhase 3Ages 18-75Rapport Therapeutics13US sites
11 states - An Open Label Trial to Evaluate the Efficacy and Safety of PRAX-628 in Adults With Focal Onset or Tonic-Clonic SeizuresMost sites in Texas, Arizona and FloridaRecruitingPhase 2Ages 18-75Praxis Precision Medicines8US sites
7 states - A Long-term Study of the Safety and Effectiveness of RAP-219 in Adults With Focal Onset SeizuresMost sites in Idaho, Minnesota and New YorkRecruitingPhase 2Ages 18-70Rapport Therapeutics7US sites
7 states - A Safety, Tolerability, and Preliminary Efficacy of Low-intensity Focused Ultrasound Neuromodulation in Patients With Drug-resistant EpilepsyMost sites in California, Massachusetts and VirginiaRecruitingPhase 1/2Ages 18+NaviFUS3US sites
3 states - Optimizing Therapy in Epilepsy Using Seizure Forecasts Via EEG and WearablesMost sites in Arizona, Florida and MinnesotaRecruitingEarly Phase 1Ages 18-75Mayo Clinic3US sites
3 states - Spatial Scene Recognition Memory in Epilepsy SurgeryMost sites in California and GeorgiaRecruitingAges 18-55University of California, Davis2US sites
2 states - Breathing Rescue for SUDEP PreventionOnly in TexasRecruitingAges 18+The University of Texas Health Science Center, Houston1US site
- Investigating Epilepsy: Screening and EvaluationOnly in MarylandRecruitingAges 8-110National Institute of Neurological Disorders and Stroke (NINDS)1US site
- Links Between Epileptic Activity, Sleep Disruption and Mental Content During SleepOnly in North CarolinaRecruitingAges 18-55Hospices Civils de Lyon1US site
- Localizing Epileptic Networks Using MRI and iEEGOnly in PennsylvaniaRecruitingEarly Phase 1Ages 18+University of Pennsylvania1US site
- Non-Invasive Low Intensity Focused Ultrasound Stimulation for Drug-Resistant EpilepsyOnly in CaliforniaRecruitingAges 21-65University of California, San Francisco1US site
- Sleep Architecture & Cognition in Focal EpilepsyOnly in CaliforniaRecruitingAges 18-40University of California, Davis1US site
- Study of Transcranial Direct Current Stimulation to Treat EpilepsyOnly in MinnesotaRecruitingAges 6+Mayo Clinic1US site
- Surgery as a Treatment for Medically Intractable EpilepsyOnly in MarylandRecruitingAges 8-99National Institute of Neurological Disorders and Stroke (NINDS)1US site
- Temporal Interference Brain Stimulation for Adults With Drug-Resistant Epilepsy Undergoing Stereo-EEG MonitoringOnly in North CarolinaRecruitingAges 18+Duke University1US site
- A Clinical Study on the Efficacy and Safety of Zonisamide as a First Add-On Treatment in Epileptic SeizuresRecruitingPhase 4Ages 1-14Affiliated Hospital of Nantong UniversityNo US site yet
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Who runs the Focal Epilepsy trials in the US, and what stage they are in
Of the 21 Focal Epilepsy trials with a US site, 4 are in Phase 3, the last stage before a company can ask the FDA for approval. Earlier Phase 1 or 2 tests of safety and dosing make up 6 of them. One is a Phase 4 study of an already approved treatment. The remaining 10 have no drug phase, such as studies that follow people over time or test a device or a way of giving care. Companies run 10 of them, and universities, hospitals, foundations and government groups run 11. The sponsors with the most are Rapport Therapeutics (3), Mayo Clinic (2) and National Institute of Neurological Disorders and Stroke (NINDS) (2). The most recently listed one first appeared on ClinicalTrials.gov on August 14, 2026.
Focal Epilepsy trials in the US, state by state
Of the 21 Focal Epilepsy trials with a US site, 4 accept children under 18. Their open sites are in 4 states, most often Maryland, Minnesota and North Carolina. A trial counts once in each state where it has an open site, and some trials accept both children and adults.
Show the other 25 states
US hospitals running the most Focal Epilepsy trials
Centers that run trials for a rare condition often see more people with it than most clinics do, so this list can also help you find doctors who know Focal Epilepsy.
- Vanderbilt University Medical CenterNashville, Tennessee4 trials
- Asheville Neurology SpecialistsAsheville, North Carolina2 trials
- Baylor College of MedicineHouston, Texas2 trials
- Cleveland ClinicCleveland, Ohio2 trials
- Consultants in Epilepsy and Neurology, PLLCBoise, Idaho2 trials
- Mid-Atlantic Epilepsy and Sleep CenterBethesda, Maryland2 trials
- National Institutes of Health Clinical CenterBethesda, Maryland2 trials
- Northeast Regional Epilepsy GroupHackensack, New Jersey2 trials
- NYU Langone Comprehensive Epilepsy CenterNew York, New York2 trials
- Southern Illinois University School of MedicineSpringfield, Illinois2 trials
Help getting to a Focal Epilepsy trial far from home
Ask the study team whether the trial pays back travel, parking and hotel costs, because many sponsors do. The FDA's guidance on paying research volunteers says paying back these costs does not count as pressuring someone to join.
These nonprofits also help patients reach care, and each one sets its own rules.
- Mercy Medical Angels
- Pays for gas cards, ground rides and airline tickets anywhere in the US, and it lists clinical trials as a reason to travel. Household income at or below 300% of the federal poverty guidelines, and usually a trip of 50 miles or more each way.
- Air Charity Network
- Volunteer pilots in all 50 states fly patients for free in small private planes, and members also fly people taking part in clinical trials. You must be able to walk and sit upright for the flight, show financial need and have a backup plan if weather cancels it.
- Ronald McDonald House
- Gives families a room near the hospital while a child gets care, through 394 House programs around the world. Families of a sick child, with rules set by each local chapter.
- Healthcare Hospitality Network
- Keeps a map of hospitality houses near hospitals, and most member houses charge little or nothing to patients and families. Each house sets its own rules, so check with the house near your study site.
Program details were checked on each program's website on October 24, 2026.
Questions about finding a Focal Epilepsy trial near you
Are there Focal Epilepsy clinical trials near me?
As of November 13, 2026, 42 Focal Epilepsy clinical trials are recruiting now and 5 are not yet recruiting. In the US, 21 of them have at least 1 open site, across 34 states and Washington, DC. Enter your ZIP code on this page to rank every one of them by the distance to its closest open site, with the sites shown on a map.
Which states have Focal Epilepsy clinical trial sites?
Recruiting Focal Epilepsy trials list open sites in 34 states and Washington, DC. California, North Carolina and Florida have the most, and the table on this page lists every state.
Are there Focal Epilepsy trials for children near me?
Of the 21 Focal Epilepsy trials with a US site, 4 accept children under 18. Their open sites are in 4 states, most often Maryland, Minnesota and North Carolina. Each trial sets its own age limits, so check the ages listed on a trial before you contact it.
Who pays for travel to a Focal Epilepsy clinical trial?
Many trial sponsors pay back travel, parking and hotel costs, so ask the study team before you rule out a far-away site. The FDA's guidance says paying back these costs does not count as pressuring someone to join. Charities such as Mercy Medical Angels and Air Charity Network can also help with rides and flights.
What if there is no Focal Epilepsy trial near me?
Some trials send staff to your home or use a local lab, so fewer visits happen at the study site. You can also sign up on this page to get an email when a Focal Epilepsy trial opens a new site or changes status.
How is the distance to a trial site measured?
Distances are straight-line miles from the center of your ZIP code to each study site's listed location, not driving distance. Your browser looks up the ZIP code's coordinates with a free map service, Zippopotam.us, and the ZIP code is never sent to or stored by Trial Friend.
FDA-approved for Focal Epilepsy: Briviact (brivaracetam), Fycompa (perampanel), Keppra (levetiracetam), Lamictal (lamotrigine), Vimpat (lacosamide), Xcopri (cenobamate), Afinitor Disperz (everolimus), Aptiom (eslicarbazepine acetate) and 13 more on the disease page.
Clinical trials near you for related conditions
Source: ClinicalTrials.gov, trials with status Recruiting or Not yet recruiting. Refreshed every 6 hours; counts as of November 13, 2026. Sites that ClinicalTrials.gov lists as closed or withdrawn are left out. Children means the trial's age group includes people under 18.