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Hereditary Spastic Paraplegia Clinical Trials Near Me

As of November 13, 2026, 17 Hereditary Spastic Paraplegia clinical trials are recruiting now and 1 is not yet recruiting. In the US, 8 of them have at least 1 open site, across 10 states. Enter your ZIP code below to see which are closest to you.

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All 17 Hereditary Spastic Paraplegia trials and their US sites

Enter your ZIP code above to sort them by how far their nearest open site is from you.

  1. Spastic Paraplegia - Centers of Excellence Research Network
    Most sites in Massachusetts, Texas and Washington
    RecruitingBoston Children's Hospital
    11US sites
    8 states
  2. Hereditary Spastic Paraplegia Genomic Sequencing Initiative (HSPseq)
    Only in Massachusetts
    RecruitingAges 1 Month-30Boston Children's Hospital
    1US site
  3. Melpida: Recombinant Adeno-associated Virus (Serotype 9) Encoding a Codon Optimized Human AP4M1 Transgene (hAP4M1opt)
    Only in Texas
    RecruitingPhase 1/2Ages 4 Months-10Elpida Therapeutics SPC
    1US site
  4. Natural History Study of Patients with HPDL Mutations
    Only in California
    RecruitingUniversity of California, San Diego
    1US site
  5. Neuromodulation to Enhance Motor Function in HSP
    Only in Kentucky
    RecruitingAges 18+Rahul Sachdeva
    1US site
  6. Phase 3 Efficacy Study With Concurrent Control of IT MELPIDA in SPG50.Concurrent Controls.
    Only in Texas
    RecruitingPhase 3Ages 4 Months-72 MonthsElpida Therapeutics SPC
    1US site
  7. Registry and Natural History Study for Early Onset Hereditary Spastic Paraplegia
    Only in Massachusetts
    RecruitingUp to age 30Boston Children's Hospital
    1US site
  8. A Prospective Cohort Study of ITB Treatment for HSP
    RecruitingAges 14-70Shanghai 6th People's Hospital
    No US site yet
  9. A Prospective Cohort Study of Surgical Treatment for Foot Deformities in HSP
    RecruitingAges 10-45Shanghai 6th People's Hospital
    No US site yet
  10. Calcium Folinate Treatment of Spastic Paraplegia 56
    RecruitingEarly Phase 1Shanghai 6th People's Hospital
    No US site yet
  11. Gait Analysis Parameter and Upper Limb Evaluation in Adult Patients With Neurological or Metabolic Pathology
    RecruitingAges 18+Centre Hospitalier Universitaire de Liege
    No US site yet
  12. Phenotypes, Biomarkers and Pathophysiology in Hereditary Spastic Paraplegias and Related Disorders
    RecruitingDr. Rebecca Schule
    No US site yet
  13. Rare Disease Registry Database for Movement Disorders in Southern Anhui Province
    RecruitingFirst Affiliated Hospital of Wannan Medical College
    No US site yet
  14. Robot-assisted Walking Treatment in Hereditary Spastic Paraplegia (HSP)
    RecruitingAges 4-70IRCCS Eugenio Medea
    No US site yet
  15. STOP-HSP.Net: a Registry for Hereditary Spastic Paraplegia as an Integration Tool for Future Therapeutic Strategies
    RecruitingIRCCS Fondazione Stella Maris
    No US site yet
  16. The preSPG4 Study - Studying the Prodromal and Early Phase of SPG4
    RecruitingAges 18-70University Hospital Tuebingen
    No US site yet
  17. TreatHSP Platform: Adaptive Natural History Platform for Ataxias, HSPs, and Spastic Ataxias
    RecruitingAges 5+Heidelberg University
    No US site yet
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Who runs the Hereditary Spastic Paraplegia trials in the US, and what stage they are in

Of the 8 Hereditary Spastic Paraplegia trials with a US site, 1 is in Phase 3, the last stage before a company can ask the FDA for approval. Earlier Phase 1 or 2 tests of safety and dosing make up 2 of them. The remaining 5 have no drug phase, such as studies that follow people over time or test a device or a way of giving care. Companies run 3 of them, and universities, hospitals, foundations and government groups run 5. The sponsors with the most are Boston Children's Hospital (3) and Elpida Therapeutics SPC (2). The most recently listed one first appeared on ClinicalTrials.gov on February 18, 2026.

Hereditary Spastic Paraplegia trials in the US, state by state

Of the 8 Hereditary Spastic Paraplegia trials with a US site, 7 accept children under 18. Their open sites are in 9 states, most often Massachusetts, Texas and California. A trial counts once in each state where it has an open site, and some trials accept both children and adults.

StateTrialsChildrenAdultsCities with the most
Massachusetts443Boston (4)
Texas331Dallas (3), Houston (1)
California111San Diego (1)
Florida111Miami (1)
Iowa111Iowa City (1)
Kentucky101Lexington (1)
Michigan111Ann Arbor (1)
New York111New York (1)
Ohio111Cincinnati (1)
Washington111Seattle (1)

US hospitals running the most Hereditary Spastic Paraplegia trials

Centers that run trials for a rare condition often see more people with it than most clinics do, so this list can also help you find doctors who know Hereditary Spastic Paraplegia.

  1. Boston Children's HospitalBoston, Massachusetts4 trials
  2. Children's Medical Center DallasDallas, Texas1 trial
  3. Cincinnati Children's Hospital Medical CenterCincinnati, Ohio1 trial
  4. Columbia University - Irving Medical CenterNew York, New York1 trial
  5. Eun Hae LeeSan Diego, California1 trial
  6. Massachusetts General HospitalBoston, Massachusetts1 trial
  7. Scottish Rite for ChildrenDallas, Texas1 trial
  8. Seattle Children's HospitalSeattle, Washington1 trial
  9. Texas Children's HospitalHouston, Texas1 trial
  10. University of Iowa Carver College of MedicineIowa City, Iowa1 trial

Help getting to a Hereditary Spastic Paraplegia trial far from home

Ask the study team whether the trial pays back travel, parking and hotel costs, because many sponsors do. The FDA's guidance on paying research volunteers says paying back these costs does not count as pressuring someone to join.

These nonprofits also help patients reach care, and each one sets its own rules.

Mercy Medical Angels
Pays for gas cards, ground rides and airline tickets anywhere in the US, and it lists clinical trials as a reason to travel. Household income at or below 300% of the federal poverty guidelines, and usually a trip of 50 miles or more each way.
Air Charity Network
Volunteer pilots in all 50 states fly patients for free in small private planes, and members also fly people taking part in clinical trials. You must be able to walk and sit upright for the flight, show financial need and have a backup plan if weather cancels it.
Ronald McDonald House
Gives families a room near the hospital while a child gets care, through 394 House programs around the world. Families of a sick child, with rules set by each local chapter.
Healthcare Hospitality Network
Keeps a map of hospitality houses near hospitals, and most member houses charge little or nothing to patients and families. Each house sets its own rules, so check with the house near your study site.

Program details were checked on each program's website on October 24, 2026.

Questions about finding a Hereditary Spastic Paraplegia trial near you

Are there Hereditary Spastic Paraplegia clinical trials near me?

As of November 13, 2026, 17 Hereditary Spastic Paraplegia clinical trials are recruiting now and 1 is not yet recruiting. In the US, 8 of them have at least 1 open site, across 10 states. Enter your ZIP code on this page to rank every one of them by the distance to its closest open site, with the sites shown on a map.

Which states have Hereditary Spastic Paraplegia clinical trial sites?

Recruiting Hereditary Spastic Paraplegia trials list open sites in California, Florida, Iowa, Kentucky, Massachusetts, Michigan, New York, Ohio, Texas and Washington.

Are there Hereditary Spastic Paraplegia trials for children near me?

Of the 8 Hereditary Spastic Paraplegia trials with a US site, 7 accept children under 18. Their open sites are in 9 states, most often Massachusetts, Texas and California. Each trial sets its own age limits, so check the ages listed on a trial before you contact it.

Who pays for travel to a Hereditary Spastic Paraplegia clinical trial?

Many trial sponsors pay back travel, parking and hotel costs, so ask the study team before you rule out a far-away site. The FDA's guidance says paying back these costs does not count as pressuring someone to join. Charities such as Mercy Medical Angels and Air Charity Network can also help with rides and flights.

What if there is no Hereditary Spastic Paraplegia trial near me?

Some trials send staff to your home or use a local lab, so fewer visits happen at the study site. You can also sign up on this page to get an email when a Hereditary Spastic Paraplegia trial opens a new site or changes status.

How is the distance to a trial site measured?

Distances are straight-line miles from the center of your ZIP code to each study site's listed location, not driving distance. Your browser looks up the ZIP code's coordinates with a free map service, Zippopotam.us, and the ZIP code is never sent to or stored by Trial Friend.

Source: ClinicalTrials.gov, trials with status Recruiting or Not yet recruiting. Refreshed every 6 hours; counts as of November 13, 2026. Sites that ClinicalTrials.gov lists as closed or withdrawn are left out. Children means the trial's age group includes people under 18.