Also on Trial Friend:Neurofibromatosis Type 1 pageMatch Me
All 36 Neurofibromatosis Type 1 trials and their US sites
Enter your ZIP code above to sort them by how far their nearest open site is from you.
- A Phase I/II Study of Trametinib and Azacitidine for Patients With Newly Diagnosed Juvenile Myelomonocytic LeukemiaMost sites in California, Arizona and ColoradoRecruitingPhase 1/2Ages 1 Month-21Therapeutic Advances in Childhood Leukemia Consortium21US sites
20 states - Selumetinib for the Prevention of Plexiform Neurofibroma Growth in NF Type 1Most sites in California, Illinois and MarylandRecruitingPhase 2Ages 1-8University of Alabama at Birmingham15US sites
12 states - A Phase 2, Open-Label Study to Evaluate the Safety and Effects of HLX-1502 in Patients With Neurofibromatosis Type 1Most sites in California, Illinois and AlabamaRecruitingPhase 2Ages 12+Healx14US sites
12 states - Study of Cabozantinib With Selumetinib for Plexiform NeurofibromasMost sites in Alabama, California and District of ColumbiaRecruitingPhase 1Ages 16+Girish Dhall, MD8US sites
8 states - Innovative Trial for Understanding the Impact of Targeted Therapies in NF2-Related Schwannomatosis (INTUITT-NF2)Most sites in California, Florida and MarylandRecruitingPhase 2Ages 12+Scott R. Plotkin, MD, PhD5US sites
5 states - A Study to Evaluate the Feasibility of a Physiologic Biomarker to Assess Pain and Other Sensory Problems Using Pupillometry in Participants With Neurofibromatosis Type 1 (NF1)Most sites in District of Columbia and MarylandRecruitingAges 1-120National Cancer Institute (NCI)2US sites
2 states - Development and Validation of Patient Reported Outcome (PRO) Measures for Individuals With Neurofibromatosis 1 (NF1) and Plexiform Neurofibromas (pNFs)Most sites in Maryland and PennsylvaniaRecruitingAges 5+National Cancer Institute (NCI)2US sites
2 states - Early Phase Study Evaluating MEK and MDM2 Inhibition in Patients With NF1 and MPNSTMost sites in District of Columbia and TexasRecruitingPhase 1/2Ages 18+AeRang Kim2US sites
2 states - Acceptance and Commitment Therapy for Caregivers of Children With a RASopathy: An Internal Pilot Feasibility Study and Follow-up Randomized Controlled TrialOnly in MarylandRecruitingAges 18+National Cancer Institute (NCI)1US site
- Cyclin-Dependent Kinase (CDK)4/6 Inhibitor Abemaciclib for Neurofibromatosis Type I (NF1) Related Atypical NeurofibromasOnly in MarylandRecruitingPhase 1/2Ages 12+National Cancer Institute (NCI)1US site
- Development of Patient-Reported Outcome Measures Assessing Tumor Visibility and Appearance Concerns in Neurofibromatosis Type 1: A Qualitative StudyOnly in MarylandRecruitingAges 5-120National Cancer Institute (NCI)1US site
- Familial Investigations of Childhood Cancer PredispositionOnly in TennesseeRecruitingSt. Jude Children's Research Hospital1US site
- Feasibility and Tolerability of IMLYGIC for the Treatment of Cutaneous Neurofibromas in Adults With NF1Only in MarylandRecruitingPhase 1Ages 18+Johns Hopkins University1US site
- Identification of Pre-Malignant Lesions In Pediatric Patients With Neurofibromatosis Type 1 Using Novel Magnetic Resonance Imaging Techniques Paired With Artificial IntelligenceOnly in CaliforniaRecruitingAges 5-17Nicole Baca1US site
- Mirdametinib Monotherapy in Adults With Neurofibromatosis 1 (NF1) and Cutaneous Neurofibromas (cNF).Only in MarylandRecruitingPhase 1/2Ages 18+Johns Hopkins University1US site
- MT2021-08T Cell Receptor Alpha/Beta Depletion PBSC Transplantation for Heme MalignanciesOnly in MinnesotaRecruitingPhase 2Up to age 60Masonic Cancer Center, University of Minnesota1US site
- Natural History Study of Patients With Neurofibromatosis Type 2Only in MarylandRecruitingAges 8-75National Institute of Neurological Disorders and Stroke (NINDS)1US site
- PAS-004 in Adults Who Have Neurofibromatosis Type 1 With Plexiform NeurofibromasOnly in AlabamaRecruitingPhase 1Ages 18+Pasithea Therapeutics1US site
- Phase I Trial of TURALIO(R) (Pexidartinib, PLX3397) in Children and Young Adults With Refractory Leukemias and Refractory Solid Tumors Including Neurofibromatosis Type 1 (NF1) Associated Plexiform Neurofibromas (PN) and Tenosynovial Giant Cell Tumor ...Only in MarylandRecruitingPhase 1Ages 3-35National Cancer Institute (NCI)1US site
- RASopathy BiorepositoryOnly in OhioRecruitingChildren's Hospital Medical Center, Cincinnati1US site
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Who runs the Neurofibromatosis Type 1 trials in the US, and what stage they are in
None of the 25 Neurofibromatosis Type 1 trials with a US site is in Phase 3, the last stage before a company can ask the FDA for approval. Earlier Phase 1 or 2 tests of safety and dosing make up 14 of them. The remaining 11 have no drug phase, such as studies that follow people over time or test a device or a way of giving care. Companies run 2 of them, and universities, hospitals, foundations and government groups run 23. The sponsors with the most are National Cancer Institute (NCI) (7), University of Alabama at Birmingham (3) and Johns Hopkins University (2). The most recently listed one first appeared on ClinicalTrials.gov on April 13, 2026.
Neurofibromatosis Type 1 trials in the US, state by state
Of the 25 Neurofibromatosis Type 1 trials with a US site, 18 accept children under 18. Their open sites are in 22 states and Washington, DC, most often Maryland, California and District of Columbia. A trial counts once in each state where it has an open site, and some trials accept both children and adults.
Show the other 13 states
US hospitals running the most Neurofibromatosis Type 1 trials
Centers that run trials for a rare condition often see more people with it than most clinics do, so this list can also help you find doctors who know Neurofibromatosis Type 1.
- National Institutes of Health Clinical CenterBethesda, Maryland7 trials
- Children's Hospital of PhiladelphiaPhiladelphia, Pennsylvania5 trials
- Children's National HospitalWashington D.C., District of Columbia4 trials
- Cincinnati Children's Hospital Medical CenterCincinnati, Ohio4 trials
- Childrens of AlabamaBirmingham, Alabama3 trials
- Johns Hopkins HospitalBaltimore, Maryland3 trials
- Boston Children's HospitalBoston, Massachusetts2 trials
- Children's Hospital Los AngelesLos Angeles, California2 trials
- Children's Hospital of Los AngelesLos Angeles, California2 trials
- Children's National Medical CenterWashington D.C., District of Columbia2 trials
Help getting to a Neurofibromatosis Type 1 trial far from home
Ask the study team whether the trial pays back travel, parking and hotel costs, because many sponsors do. The FDA's guidance on paying research volunteers says paying back these costs does not count as pressuring someone to join.
These nonprofits also help patients reach care, and each one sets its own rules.
- Mercy Medical Angels
- Pays for gas cards, ground rides and airline tickets anywhere in the US, and it lists clinical trials as a reason to travel. Household income at or below 300% of the federal poverty guidelines, and usually a trip of 50 miles or more each way.
- Air Charity Network
- Volunteer pilots in all 50 states fly patients for free in small private planes, and members also fly people taking part in clinical trials. You must be able to walk and sit upright for the flight, show financial need and have a backup plan if weather cancels it.
- Ronald McDonald House
- Gives families a room near the hospital while a child gets care, through 394 House programs around the world. Families of a sick child, with rules set by each local chapter.
- Healthcare Hospitality Network
- Keeps a map of hospitality houses near hospitals, and most member houses charge little or nothing to patients and families. Each house sets its own rules, so check with the house near your study site.
Program details were checked on each program's website on October 24, 2026.
Questions about finding a Neurofibromatosis Type 1 trial near you
Are there Neurofibromatosis Type 1 clinical trials near me?
As of November 13, 2026, 36 Neurofibromatosis Type 1 clinical trials are recruiting now and 14 are not yet recruiting. In the US, 25 of them have at least 1 open site, across 22 states and Washington, DC. Enter your ZIP code on this page to rank every one of them by the distance to its closest open site, with the sites shown on a map.
Which states have Neurofibromatosis Type 1 clinical trial sites?
Recruiting Neurofibromatosis Type 1 trials list open sites in 22 states and Washington, DC. Maryland, Alabama and California have the most, and the table on this page lists every state.
Are there Neurofibromatosis Type 1 trials for children near me?
Of the 25 Neurofibromatosis Type 1 trials with a US site, 18 accept children under 18. Their open sites are in 22 states and Washington, DC, most often Maryland, California and District of Columbia. Each trial sets its own age limits, so check the ages listed on a trial before you contact it.
Who pays for travel to a Neurofibromatosis Type 1 clinical trial?
Many trial sponsors pay back travel, parking and hotel costs, so ask the study team before you rule out a far-away site. The FDA's guidance says paying back these costs does not count as pressuring someone to join. Charities such as Mercy Medical Angels and Air Charity Network can also help with rides and flights.
What if there is no Neurofibromatosis Type 1 trial near me?
Some trials send staff to your home or use a local lab, so fewer visits happen at the study site. You can also sign up on this page to get an email when a Neurofibromatosis Type 1 trial opens a new site or changes status.
How is the distance to a trial site measured?
Distances are straight-line miles from the center of your ZIP code to each study site's listed location, not driving distance. Your browser looks up the ZIP code's coordinates with a free map service, Zippopotam.us, and the ZIP code is never sent to or stored by Trial Friend.
FDA-approved for Neurofibromatosis Type 1: Gomekli (mirdametinib), Koselugo (selumetinib).
Clinical trials near you for related conditions
Source: ClinicalTrials.gov, trials with status Recruiting or Not yet recruiting. Refreshed every 6 hours; counts as of November 13, 2026. Sites that ClinicalTrials.gov lists as closed or withdrawn are left out. Children means the trial's age group includes people under 18.