Also on Trial Friend:Multiple Sclerosis pageMatch Me
All 370 Multiple Sclerosis trials and their US sites
Enter your ZIP code above to sort them by how far their nearest open site is from you.
- A Study Evaluating the Real World Experience of Participants Treated With BRIUMVI® (Ublituximab-xiiy) for Relapsing Multiple Sclerosis (RMS)Most sites in Florida, Texas and ColoradoRecruitingAges 18+TG Therapeutics111US sites
35 states - Efficacy and Safety of Remibrutinib After Switching From Ocrelizumab in Participants Living With Relapsing Multiple Sclerosis.Most sites in Florida, Ohio and TexasRecruitingPhase 3Ages 40-70Novartis Pharmaceuticals44US sites
23 states - A Study to Evaluate the Efficacy and Safety of Remibrutinib in Secondary Progressive Multiple SclerosisMost sites in Florida, Arizona and CaliforniaRecruitingPhase 3Ages 18-65Novartis Pharmaceuticals42US sites
20 states - Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVOMost sites in Kansas, Missouri and TexasRecruitingPhase 1Ages 18+National Cancer Institute (NCI)40US sites
14 states - Study to Evaluate Safety, Efficacy and Pharmacokinetics (PK) of a Modified Regimen of UblituximabMost sites in Massachusetts, Georgia and OhioRecruitingPhase 3Ages 18-65TG Therapeutics39US sites
25 states - Non-inferiority Study of Frexalimab Subcutaneous Administration Compared to Intravenous Administration in Adult Participants With Multiple SclerosisMost sites in Florida, Texas and ArizonaRecruitingPhase 3Ages 18-60Sanofi34US sites
17 states - A Study of Orelabrutinib in Patients With Secondary Progressive Multiple SclerosisMost sites in Florida, California and ArizonaRecruitingPhase 3Ages 18-60Zenas BioPharma (USA)26US sites
15 states - Best Available Therapy Versus Autologous Hematopoietic Stem Cell Transplant for Multiple Sclerosis (BEAT-MS)Most sites in New York, Ohio and TexasRecruitingPhase 3Ages 18-55National Institute of Allergy and Infectious Diseases (NIAID)20US sites
15 states - A Study of Orelabrutinib in Patients With Primary Progressive Multiple SclerosisMost sites in Florida, Kansas and OhioRecruitingPhase 3Ages 18-60Zenas BioPharma (USA)18US sites
12 states - A Study to Evaluate the Efficacy, Safety and Tolerability of BMS-986368 in Participants With Multiple Sclerosis SpasticityMost sites in Florida, Michigan and OhioRecruitingPhase 2Ages 18-70Celgene15US sites
12 states - Study to Evaluate the Effectiveness and Safety of Ozanimod Compared to Fingolimod in Children and Adolescents With Relapsing Remitting Multiple SclerosisMost sites in California, Florida and IllinoisRecruitingPhase 3Ages 10-17Bristol-Myers Squibb9US sites
8 states - The SetPoint System as a Pro-Remyelination Therapy for Relapsing-Remitting Multiple Sclerosis: A Pilot StudyMost sites in Texas, California and GeorgiaRecruitingAges 22-60SetPoint Medical9US sites
8 states - An Open-label Study of AZD0120 in Adults With Multiple SclerosisMost sites in New York, Colorado and District of ColumbiaRecruitingPhase 1Ages 18-60AstraZeneca8US sites
7 states - Treatment of Participants With Primary or Secondary Progressive Multiple SclerosisMost sites in California, Kansas and MinnesotaRecruitingPhase 1/2Ages 18-65Tr1X8US sites
8 states - A Phase 2a Study of SUN-627 in Participants With Non-Active Secondary Progressive and Primary Progressive Multiple Sclerosis (SPMS/PPMS)Most sites in Florida, Georgia and New YorkRecruitingPhase 2Ages 18-70Sundance Biosciences7US sites
7 states - A Study of Ocrelizumab Administered Subcutaneously in Participants With Multiple Sclerosis Who Switch From an Approved Anti-CD20 TherapyMost sites in Georgia, Alabama and ArizonaRecruitingPhase 4Ages 18-65Genentech7US sites
6 states - A Study to Investigate Multiple Sclerosis Relapse Prevention With mRNA-1195 Compared With Placebo in Participants Aged 18 to ≤55 YearsMost sites in Texas, Michigan and MissouriRecruitingPhase 2Ages 18-55ModernaTX6US sites
4 states - Care in Multiple Sclerosis (MS)Most sites in Alabama, California and ColoradoRecruitingAges 18-29NYU Langone Health6US sites
6 states - Study of KITE-363 in Participants With Autoimmune Neurologic Diseases That Did Not Respond to Usual TreatmentMost sites in California, New York and UtahRecruitingPhase 1Ages 18-75Kite, A Gilead Company5US sites
4 states - Central Vein Sign in Multiple Sclerosis Extension StudyMost sites in California, Ohio and PennsylvaniaRecruitingAges 18-65The Cleveland Clinic3US sites
3 states
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Who runs the Multiple Sclerosis trials in the US, and what stage they are in
Of the 160 Multiple Sclerosis trials with a US site, 11 are in Phase 3, the last stage before a company can ask the FDA for approval. Earlier Phase 1 or 2 tests of safety and dosing make up 39 of them. Phase 4 studies of an already approved treatment make up 7. The remaining 103 have no drug phase, such as studies that follow people over time or test a device or a way of giving care. Companies run 33 of them, and universities, hospitals, foundations and government groups run 127. The sponsors with the most are University of Illinois Chicago (6), Novartis Pharmaceuticals (5) and Brigham and Women's Hospital (4). The most recently listed one first appeared on ClinicalTrials.gov on November 10, 2026.
Multiple Sclerosis trials in the US, state by state
Of the 160 Multiple Sclerosis trials with a US site, 13 accept children under 18. Their open sites are in 15 states, most often California, Florida and Maryland. A trial counts once in each state where it has an open site, and some trials accept both children and adults.
Show the other 31 states
US hospitals running the most Multiple Sclerosis trials
Centers that run trials for a rare condition often see more people with it than most clinics do, so this list can also help you find doctors who know Multiple Sclerosis.
- National Institutes of Health Clinical CenterBethesda, Maryland6 trials
- Medical College of WisconsinMilwaukee, Wisconsin5 trials
- University of Kansas Medical CenterKansas City, Kansas5 trials
- Aqualane Clinical ResearchNaples, Florida4 trials
- Northwestern Memorial HospitalChicago, Illinois4 trials
- Premier NeurologyGreenville, South Carolina4 trials
- Shirley Ryan AbilityLabChicago, Illinois4 trials
- University of Illinois at ChicagoChicago, Illinois4 trials
- Washington University School of MedicineSt Louis, Missouri4 trials
- Cleveland ClinicCleveland, Ohio3 trials
Help getting to a Multiple Sclerosis trial far from home
Ask the study team whether the trial pays back travel, parking and hotel costs, because many sponsors do. The FDA's guidance on paying research volunteers says paying back these costs does not count as pressuring someone to join.
These nonprofits also help patients reach care, and each one sets its own rules.
- Mercy Medical Angels
- Pays for gas cards, ground rides and airline tickets anywhere in the US, and it lists clinical trials as a reason to travel. Household income at or below 300% of the federal poverty guidelines, and usually a trip of 50 miles or more each way.
- Air Charity Network
- Volunteer pilots in all 50 states fly patients for free in small private planes, and members also fly people taking part in clinical trials. You must be able to walk and sit upright for the flight, show financial need and have a backup plan if weather cancels it.
- Ronald McDonald House
- Gives families a room near the hospital while a child gets care, through 394 House programs around the world. Families of a sick child, with rules set by each local chapter.
- Healthcare Hospitality Network
- Keeps a map of hospitality houses near hospitals, and most member houses charge little or nothing to patients and families. Each house sets its own rules, so check with the house near your study site.
Program details were checked on each program's website on October 24, 2026.
Questions about finding a Multiple Sclerosis trial near you
Are there Multiple Sclerosis clinical trials near me?
As of November 13, 2026, 370 Multiple Sclerosis clinical trials are recruiting now and 154 are not yet recruiting. In the US, 160 of them have at least 1 open site, across 40 states and Washington, DC. Enter your ZIP code on this page to rank every one of them by the distance to its closest open site, with the sites shown on a map.
Which states have Multiple Sclerosis clinical trial sites?
Recruiting Multiple Sclerosis trials list open sites in 40 states and Washington, DC. California, Illinois and New York have the most, and the table on this page lists every state.
Are there Multiple Sclerosis trials for children near me?
Of the 160 Multiple Sclerosis trials with a US site, 13 accept children under 18. Their open sites are in 15 states, most often California, Florida and Maryland. Each trial sets its own age limits, so check the ages listed on a trial before you contact it.
Who pays for travel to a Multiple Sclerosis clinical trial?
Many trial sponsors pay back travel, parking and hotel costs, so ask the study team before you rule out a far-away site. The FDA's guidance says paying back these costs does not count as pressuring someone to join. Charities such as Mercy Medical Angels and Air Charity Network can also help with rides and flights.
What if there is no Multiple Sclerosis trial near me?
Some trials send staff to your home or use a local lab, so fewer visits happen at the study site. You can also sign up on this page to get an email when a Multiple Sclerosis trial opens a new site or changes status.
How is the distance to a trial site measured?
Distances are straight-line miles from the center of your ZIP code to each study site's listed location, not driving distance. Your browser looks up the ZIP code's coordinates with a free map service, Zippopotam.us, and the ZIP code is never sent to or stored by Trial Friend.
FDA-approved for Multiple Sclerosis: Aubagio (teriflunomide), Briumvi (ublituximab), Copaxone (glatiramer acetate), Gilenya (fingolimod), Kesimpta (ofatumumab), Mayzent (siponimod), Ocrevus (ocrelizumab), Tecfidera (dimethyl fumarate) and 15 more on the disease page.
Clinical trials near you for related conditions
Source: ClinicalTrials.gov, trials with status Recruiting or Not yet recruiting. Refreshed every 6 hours; counts as of November 13, 2026. Sites that ClinicalTrials.gov lists as closed or withdrawn are left out. Children means the trial's age group includes people under 18.