Also on Trial Friend:Systemic Sclerosis pageMatch Me
All 136 Systemic Sclerosis trials and their US sites
Enter your ZIP code above to sort them by how far their nearest open site is from you.
- Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVOMost sites in Kansas, Missouri and TexasRecruitingPhase 1Ages 18+National Cancer Institute (NCI)40US sites
14 states - AlloNK®, an Allogeneic Non-genetically Modified, Cord Blood-derived NK Cell Therapy, in Combination With Rituximab, Studied in Relapsing Forms of B-cell Dependent Rheumatologic Diseases.Most sites in Texas, California and FloridaRecruitingPhase 2Ages 18+Artiva Biotherapeutics31US sites
13 states - A Study to Test Whether Nerandomilast Helps People With Systemic SclerosisMost sites in California, Florida and New YorkRecruitingPhase 3Ages 18+Boehringer Ingelheim30US sites
17 states - Platform Clinical Study for Conquering SclerodermaMost sites in California, New York and MassachusettsRecruitingPhase 2Ages 18+Scleroderma Research Foundation24US sites
18 states - EncompaSSc: Evaluation of MTX-474 in Participants With Diffuse Cutaneous Systemic Sclerosis (dcSSc)Most sites in California, Florida and TexasRecruitingPhase 2Ages 18+Mediar Therapeutics23US sites
13 states - A Study of the Efficacy and Safety of Belimumab in Adults With Systemic Sclerosis Associated Interstitial Lung DiseaseMost sites in California, Arizona and PennsylvaniaRecruitingPhase 2/3Ages 18+GlaxoSmithKline22US sites
12 states - Rollover Study for Participants Who Have Completed a Previous Clinical Study With Anifrolumab (Saphnelo) and Clinically Benefited From Continued TreatmentMost sites in California, Florida and OhioRecruitingPhase 3Ages 5-80AstraZeneca21US sites
17 states - A Phase 1 Study of FT819 in B-cell Mediated Autoimmune DiseaseMost sites in California, Florida and KentuckyRecruitingPhase 1Ages 12-70Fate Therapeutics16US sites
11 states - A Study to Investigate the Safety and Preliminary Efficacy of ALLO-329, an Allogeneic CAR T-cell Therapy, in Adults With Autoimmune DiseaseMost sites in North Carolina, South Carolina and ArizonaRecruitingPhase 1Ages 18-74Allogene Therapeutics16US sites
14 states - A Phase 1/2 Study of NKX019 in Subjects With Immune-Mediated Diseases (Ntrust-2)Most sites in Florida, New Jersey and New YorkRecruitingPhase 1/2Ages 18-75Nkarta12US sites
9 states - A Study of AZD0120 in Autoimmune DiseasesMost sites in California, New York and ArizonaRecruitingPhase 1/2Ages 18-75AstraZeneca12US sites
10 states - RESET-SSc: An Open-Label Study to Evaluate the Safety and Efficacy of CABA-201, a CD19-CAR T Cell Therapy, in Subjects With Systemic SclerosisMost sites in Illinois, New York and ConnecticutRecruitingPhase 2/3Ages 18-75Cabaletta Bio10US sites
8 states - A Safety and Efficacy Study Evaluating CTX112 in Adult Subjects With Refractory Autoimmune DiseaseMost sites in California, Illinois and IowaRecruitingPhase 1Ages 18-70CRISPR Therapeutics9US sites
8 states - The Apollo Device in Systemic Sclerosis for the Management of fatiguE, Raynaud Phenomenon and qualiTy of LifeMost sites in Louisiana, Michigan and PennsylvaniaRecruitingAges 18+Robyn T. Domsic, MD, MPH4US sites
4 states - Autologous Stem Cell Transplantation in Patients With Systemic SclerosisOnly in PennsylvaniaRecruitingPhase 2Ages 8-60Paul Szabolcs3US sites
- A Study of Nemolizumab for the Treatment of Adults With Systemic SclerosisMost sites in Michigan and TexasRecruitingPhase 2Ages 18+Galderma R&D2US sites
2 states - Phase I/II Study of AD-PluReceptor Plus Tafasitamab-cxix and Lymphodepleting Chemotherapy in Patients With Autoimmune DisordersOnly in TexasRecruitingPhase 1/2Ages 18+M.D. Anderson Cancer Center2US sites
- Sildenafil for Early Pulmonary Vascular Disease in SclerodermaMost sites in Louisiana and MarylandRecruitingPhase 2Ages 18+Johns Hopkins University2US sites
2 states - A Long-Term Follow-Up Study for Participants Previously Treated With KYV-101Only in ColoradoRecruitingAges 18+Kyverna Therapeutics1US site
- Autologous Stem Cell Transplant (ASCT) for Autoimmune DiseasesOnly in PennsylvaniaRecruitingPhase 2Ages 8-25Stephan Grupp MD PhD1US site
New trials, status changes and new sites, straight from ClinicalTrials.gov. Unsubscribe anytime.
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Who runs the Systemic Sclerosis trials in the US, and what stage they are in
Of the 44 Systemic Sclerosis trials with a US site, 5 are in Phase 3, the last stage before a company can ask the FDA for approval. Earlier Phase 1 or 2 tests of safety and dosing make up 23 of them. The remaining 16 have no drug phase, such as studies that follow people over time or test a device or a way of giving care. Companies run 20 of them, and universities, hospitals, foundations and government groups run 24. The sponsors with the most are AstraZeneca (2), Fate Therapeutics (2) and Robyn T. Domsic, MD, MPH (2). The most recently listed one first appeared on ClinicalTrials.gov on November 9, 2026.
Systemic Sclerosis trials in the US, state by state
Of the 44 Systemic Sclerosis trials with a US site, 10 accept children under 18. Their open sites are in 26 states, most often Pennsylvania, Florida and Massachusetts. A trial counts once in each state where it has an open site, and some trials accept both children and adults.
Show the other 26 states
US hospitals running the most Systemic Sclerosis trials
Centers that run trials for a rare condition often see more people with it than most clinics do, so this list can also help you find doctors who know Systemic Sclerosis.
- University of MichiganAnn Arbor, Michigan5 trials
- Hospital for Special SurgeryNew York, New York3 trials
- The University of Chicago Medical CenterChicago, Illinois3 trials
- The University of Texas Health Science Center at HoustonHouston, Texas3 trials
- Vanderbilt University Medical CenterNashville, Tennessee3 trials
- Boston Medical CenterBoston, Massachusetts2 trials
- Duke UniversityDurham, North Carolina2 trials
- Duke University Medical CenterDurham, North Carolina2 trials
- Froedtert Hospital and the Medical College of WisconsinMilwaukee, Wisconsin2 trials
- Icahn School of Medicine at Mount SinaiNew York, New York2 trials
Help getting to a Systemic Sclerosis trial far from home
Ask the study team whether the trial pays back travel, parking and hotel costs, because many sponsors do. The FDA's guidance on paying research volunteers says paying back these costs does not count as pressuring someone to join.
These nonprofits also help patients reach care, and each one sets its own rules.
- Mercy Medical Angels
- Pays for gas cards, ground rides and airline tickets anywhere in the US, and it lists clinical trials as a reason to travel. Household income at or below 300% of the federal poverty guidelines, and usually a trip of 50 miles or more each way.
- Air Charity Network
- Volunteer pilots in all 50 states fly patients for free in small private planes, and members also fly people taking part in clinical trials. You must be able to walk and sit upright for the flight, show financial need and have a backup plan if weather cancels it.
- Ronald McDonald House
- Gives families a room near the hospital while a child gets care, through 394 House programs around the world. Families of a sick child, with rules set by each local chapter.
- Healthcare Hospitality Network
- Keeps a map of hospitality houses near hospitals, and most member houses charge little or nothing to patients and families. Each house sets its own rules, so check with the house near your study site.
Program details were checked on each program's website on October 24, 2026.
Questions about finding a Systemic Sclerosis trial near you
Are there Systemic Sclerosis clinical trials near me?
As of November 13, 2026, 136 Systemic Sclerosis clinical trials are recruiting now and 67 are not yet recruiting. In the US, 44 of them have at least 1 open site, across 35 states and Washington, DC. Enter your ZIP code on this page to rank every one of them by the distance to its closest open site, with the sites shown on a map.
Which states have Systemic Sclerosis clinical trial sites?
Recruiting Systemic Sclerosis trials list open sites in 35 states and Washington, DC. California, New York and Texas have the most, and the table on this page lists every state.
Are there Systemic Sclerosis trials for children near me?
Of the 44 Systemic Sclerosis trials with a US site, 10 accept children under 18. Their open sites are in 26 states, most often Pennsylvania, Florida and Massachusetts. Each trial sets its own age limits, so check the ages listed on a trial before you contact it.
Who pays for travel to a Systemic Sclerosis clinical trial?
Many trial sponsors pay back travel, parking and hotel costs, so ask the study team before you rule out a far-away site. The FDA's guidance says paying back these costs does not count as pressuring someone to join. Charities such as Mercy Medical Angels and Air Charity Network can also help with rides and flights.
What if there is no Systemic Sclerosis trial near me?
Some trials send staff to your home or use a local lab, so fewer visits happen at the study site. You can also sign up on this page to get an email when a Systemic Sclerosis trial opens a new site or changes status.
How is the distance to a trial site measured?
Distances are straight-line miles from the center of your ZIP code to each study site's listed location, not driving distance. Your browser looks up the ZIP code's coordinates with a free map service, Zippopotam.us, and the ZIP code is never sent to or stored by Trial Friend.
FDA-approved for Systemic Sclerosis: Actemra (tocilizumab), Ofev (nintedanib).
Clinical trials near you for related conditions
Source: ClinicalTrials.gov, trials with status Recruiting or Not yet recruiting. Refreshed every 6 hours; counts as of November 13, 2026. Sites that ClinicalTrials.gov lists as closed or withdrawn are left out. Children means the trial's age group includes people under 18.