Corcept Therapeutics

This is a 2-part, Phase 2 study to evaluate the safety, tolerability, dosing, pharmacokinetics (PK), and efficacy of relacorilant in combination with nab-paclitaxel and gemcitabine in chemotherapy-naïve patients with metastatic pancreatic adenocarcinoma (PDAC).

This open-label, dose-finding, and proof of concept study will evaluate the safety, tolerability, maximum-tolerated dose (MTD) and/or optimal dose of nenocorilant when administered in combination with nivolumab in patients with advanced solid malignancies.

This is a Phase 2, open-label, global, multi-arm study to evaluate efficacy and safety of relacorilant in combination with other treatments in patients with gynecological cancers.

A Phase 1b, Open-Label Study Evaluating the Pharmacokinetics and Safety of Miricorilant in Adult Patients With Presumed Metabolic Dysfunction-Associated Steatohepatitis (MASH)

The researchers are doing this study to find out if the study drug, enzalutamide, alone or combined with the study drug, mifepristone, is effective in treating advanced or metastatic androgen receptor-positive (AR+) triple negative breast cancer (TNBC) or estrogen receptor-low breast cancer (ER-low BC), and whether these study treatments work as well as standard chemotherapy with carboplatin, paclitaxel, capecitabine, or eribulin.Show more

Rationale: Post-traumatic stress disorder (PTSD) is a psychiatric disorder that can develop in people who have experienced or witnessed a traumatic event. Symptoms of PTSD include flashbacks, nightmares, difficulty sleeping, difficulty concentrating, irritability, and avoidance of people, places, or activities that remind the person of the traumatic event. Even though there are effective treatments (e.g. exposure-based psychotherapies and antidepressants), not all patients respond. Glucocorticoid receptor (GR) antagonism is a potential therapy for the treatment of treatment-resistant post traumatic stress disorder (PTSD) based on the idea that PTSD may be caused or exacerbated by dysregulation of the body's stress response system, and on the results of several small clinical trials. By blocking the actions of cortisol at the GR, it is thought that GR antagonists may be able to reduce the severity of PTSD symptoms and improve treatment outcomes. Randomized controlled trials (RCT) can provide high-quality evidence on treatment efficacy, and optimize evidence-based selection of off-label treatments for patients. Therefore the aim is to investigate whether the psychological and biological sequelae of traumatic stress and PTSD can be targeted by blocking the glucocorticoid receptor (GR) using the generic drug mifepristone in a double blind, placebo controlled RCT. Objective: To test the hypothesis that treatment with the GR-antagonist mifepristone is more effective than placebo to reduce PTSD symptom severity in treatment-resistant PTSD. Main trial endpoints: Improvement of PTSD symptoms, as measured with the monthly version of the CAPS-5 (Clinician Administered PTSD scale) in patients with treatment-resistant PTSD, 4 weeks after the start of the intervention. Secondary trial endpoints * PTSD symptom severity as measured with the weekly version of the PCL-5, from baseline till 12 weeks after the start of the intervention (T3). * Long-term PTSD symptom severity as measured with the CAPS-5, at 12 weeks after the start of the intervention (T3). * Loss of diagnosis (score of \<26 and absence of PTSD criteria with CAPS-5), 4 weeks after the start of the intervention. * Treatment response (minimum decrease of 10 point on the PCL-5 and CAPS-5 scores) at 1, 4 and 12 weeks after the start of the intervention. * Other clinical outcomes 1, 4, and 12 weeks after the start the intervention: * disability (WHO Disability Schedule 2.0; WHO-DAS II), * sleep (Insomnia Severity Index; ISI), * subjective stress (Perceived Stress Scale; PSS), * anxiety symptoms (Beck Anxiety Inventory; BAI), * depressive symptoms (IDS-SR), * suicidal ideation and behaviour (Columbia-Suicide Severity Rating Scale). Trial design: The experimental protocol consists of a placebo-controlled double-blind RCT with 4 face-to-face meetings: * baseline (T0, 2,5 hrs); * post-intervention T1, 8 days after start (1hr); * post-intervention T2, 4 weeks after start (2hr). * post-intervention T3, 12 weeks (2hr). Trial population: 60 adult patients (male/female, 18+ years), with treatment-resistant PTSD (non-response to two evidence-based PTSD treatments, at least one of which is trauma-focused psychotherapy). Intervention Patients are randomized for treatment with the GR antagonist mifepristone (1200 mg/day for 7 days) or matching placebo (daily for 7 days). Study medication will be dispensed during the baseline measurement (T0), and taken once daily for 7 consecutive days. Clinical measurements consist of clinical interviews and questionnaires. During baseline visits a pregnancy test is conducted in woman of child bearing potential (WOCBP), and blood is drawn at T1 to assess mifepristone plasma levels. Ethical considerations relating to the clinical trial including the expected benefit to the individual subject or group of patients represented by the trial subjects as well as the nature and extent of burden and risks: Mifepristone has been clinically used for Cushing's syndrome (anti-glucocorticoid effects) and termination of pregnancy (anti-progesterone effects) for several decades. Mifepristone is generally well-tolerated, and several double-blind studies using the identical duration and dose have shown (7 days, 1200 mg) that the safety profile of mifepristone is comparable to that of placebo treatment, and study dropouts due to side effects were higher for placebo (1.6%) than for mifepristone (1.4%). The most common adverse events (AEs) were nausea, headache, dizziness, and a dry mouth and were comparable between the mifepristone and placebo groups. With regard to mifepristone's progesterone receptor activity and its indication for pregnancy termination, WOCBP who do not agree to use a non-hormonal contraceptive method (condom) during the intervention and up to 1 month after the intervention, are strictly excluded from participating in this study.Show more

This is an open-label extension study to evaluate the long-term safety of relacorilant in patients with endogenous Cushing syndrome who successfully completed participation in a Corcept-sponsored study of relacorilant and may benefit from continuing treatment.

Corcept Therapeutics is a Redwood City, California company focused on cortisol modulation, founded in 1998 by Stanford psychiatrists Alan Schatzberg and Joseph Belanoff. Korlym (mifepristone), approved in 2012, was the first FDA-approved treatment for hypercortisolism (Cushing syndrome). Its next-generation cortisol modulator relacorilant received a complete response letter for hypercortisolism in December 2025. Corcept resubmitted the application in June 2026, and the FDA decision date is December 17, 2026. The same molecule was approved as Lifyorli in March 2026 for platinum-resistant ovarian cancer in combination with nab-paclitaxel.

Corcept Therapeutics has active programs across 3 rare diseases: Adrenocortical Carcinoma, Amyotrophic Lateral Sclerosis, Cushing Disease. Each disease page on Trial Friend shows the latest recruiting trials, FDA-approved treatments, and patient resources.

Yes. Corcept Therapeutics is a rare disease specialist headquartered in Redwood City, United States, founded in 1998. The company focuses primarily on developing treatments for rare and orphan diseases, with programs targeting Adrenocortical Carcinoma, Amyotrophic Lateral Sclerosis, Cushing Disease.

The clinical trials section on this page shows active and recruiting rare disease trials sponsored by Corcept Therapeutics, pulled live from ClinicalTrials.gov. Each trial card includes the study phase, recruitment status, conditions being studied, number of trial sites, and a direct link to the full study record. You can also explore individual disease pages to see trials from all sponsors for a specific condition.

To explore enrollment, find a recruiting trial in the clinical trials list on this page and click "View full study" to see the full ClinicalTrials.gov record, which includes eligibility criteria, study locations, and contact information for each trial site. Your doctor can also help determine if a specific trial is appropriate for your condition. Not all trials are open at every location, so check the site list for one near you.

Corcept Therapeutics was founded in 1998 and is headquartered in Redwood City, United States. The company has been active for 28 years. It trades publicly under the ticker symbol CORT. As a rare disease specialist, the company dedicates its resources to developing therapies for patients with rare and orphan conditions.