Chiesi Farmaceutici

Chiesi Farmaceutici works on 13 rare diseases tracked on Trial Friend, including Acromegaly, Alpha-1 Antitrypsin Deficiency, Cystic Fibrosis and 10 more, with 9 recruiting clinical trials and 9 FDA-approved rare disease drugs.

Chiesi is an international biopharmaceutical company with a broad rare disease portfolio. Key products include Lamzede (velmanase alfa) for alfa-mannosidosis, Elfabrio (pegunigalsidase alfa) for Fabry disease, FILSUVEZ for epidermolysis bullosa, JUXTAPID/LOJUXTA (lomitapide) for homozygous familial hypercholesterolemia, Mycapssa (octreotide) for acromegaly, and FERRIPROX (deferiprone) for transfusional iron overload in sickle cell disease and thalassemia. The company also has programs in cystic fibrosis and pulmonary fibrosis.

Type
Diversified Pharma
Headquarters
Parma, Italy
Founded
1935
Website
chiesi.com
9
Active Rare Disease Trials
9
Approved Rare Disease Drugs
13
Rare Diseases in Portfolio
91
Years Active

Chiesi Farmaceutici Drug Pipeline

Chiesi Farmaceutici has 9 active clinical trials across 3 development stages, with 9 currently recruiting participants. Clinical trials advance through phases: Phase 1 tests safety in a small group, Phase 2 evaluates effectiveness and side effects, Phase 3 confirms benefit in a larger population, and Phase 4 monitors long-term safety after FDA approval.

Note: This pipeline includes all of Chiesi Farmaceutici's active interventional trials, not only those targeting rare diseases. We show the full pipeline because a company's broader research activity, therapeutic expertise, and development infrastructure directly shape its ability to advance rare disease programs. A strong overall pipeline often signals deeper clinical operations, faster enrollment capabilities, and greater commitment to bringing new treatments to patients.

Understand Chiesi Farmaceutici's pipeline
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1
Phase 21 trial
3
Phase 33 trials
Recruiting
Recruiting
Recruiting
5
Other5 trials

Chiesi Farmaceutici Clinical Trials (9)

Active and recruiting clinical trials sponsored by Chiesi Farmaceutici, sourced live from ClinicalTrials.gov. Each trial card shows the study phase, current recruitment status, conditions under investigation, study locations, eligibility criteria, and a direct link to the full ClinicalTrials.gov record. You can also download a one-page PDF summary to share with your doctor.

Note: Recruitment statuses on ClinicalTrials.gov may not immediately reflect recent FDA decisions, sponsor announcements, or enrollment changes. Always confirm a trial's current status directly with the study coordinator.

Ask about Chiesi Farmaceutici's trials
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RECRUITINGRecently updatedNCT06423573

A Study to Assess the Incidence of Skin Cancers in Patients With Epidermolysis Bullosa Receiving Filsuvez

Intervention: Filsuvez

In patients with epidermolysis bullosa (EB), collagen does not form properly, so their skin is very fragile and blisters easily. Such patients are also at greatly increased risk of developing skin cancers. Filsuvez is a topical gel used to promote healing of skin lesions in patients with certain types of EB. In this observational study, patients with either dystrophic EB (DEB) or junctional EB (JEB) will receive standard of care treatment, whether Filsuvez or something else, and will be followed for a minimum of 3 years. The main purpose is to see if the use of Filsuvez affects the likelihood of developing skin malignancies in these patient populations.

Ages not specified12 locations
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RECRUITINGPHASE2Recently updatedNCT07516951

A Study to Find an Efficacious and Safe Dose of CHF10067 (Zampilimab) in Participants With Idiopathic Pulmonary Fibrosis

Intervention: CHF10067, CHF10067, Placebo

The purpose of this study is to evaluate the efficacy, safety, and tolerability at Week 24 of 2 doses of CHF10067 (zampilimab) in participants with idiopathic pulmonary fibrosis (IPF). It is a phase IIb, multicentre, randomised, double-blind, placebo-controlled, three-arm parallel-group study. A total of 240 participants with IPF (Idiomatic Pulmonary Fibrosis) will be randomised in approximately 150 investigational sites in North and Latin America, Europe, Asia, and Oceania.

Ages 40 Years+3 locations
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RECRUITINGPHASE2, PHASE3Recently updatedNCT06328608

A Study to Learn About the Safety and Effects of the Study Drug PRX-102 in Children and Adolescents With Fabry Disease

Intervention: PRX-102 1 mg/kg every two weeks

A Study to Learn About the Safety and Effects of the Study Drug PRX-102 in Children and Adolescents with Fabry Disease.

Ages 2 Years - 17 Years12 locations
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RECRUITINGRecently updatedNCT07109375

Observational Study on Long-term Use of Pegunigalsidase Alfa in Fabry Patients in a Real-world Setting

Intervention: pegunigalsidase alfa

PEGASO is an observational study designed to collect prospective data on the effectiveness and safety of pegunigalsidase alfa in adult patients with Fabry disease, being treated or planning to start treatment, under real-world setting.

Ages 18 Years+7 locations
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RECRUITINGNAUpdated a few months agoNCT07366879

Exercise Intervention as an Adjunct to Medical Therapy in Newly Diagnosed Patients With Pulmonary Arterial Hypertension

Intervention: Home-based, remotely delivered, supervised Exercise programme

The goal of this clinical trial is to learn if an exercise programme started shortly after diagnosis improves the fitness and mental wellbeing of patients with pulmonary hypertenion over and above medication alone. It will also learn about whether extra support can help patients keep up with exercise in the long term. The main questions it aims to answer are: * Doe exercise improve how far patients can walk over six minutes * Does exercise improve quality of life scores * Does exercise improve mental health scores * Does extra support after an exercise programme help patients to continue exercising in the long term Researchers will compare the exercise programme to a control group (a group of similar patients who do not receive the exercise programme) to see the effect that exercise has. Participants in the exercise programme group will: * Undergo an exercise programme for 12 weeks, starting around 3 months after their diagnosis * They will undertake the exercise programme at home, remotely supervised by the research team with regular contact * Visit the clinic at the end of the programme for checkups and tests * Keep a diary of their exercise and how they are feeling Participants in the control group will: -Still undergo the exercise programme, but this will happen at a delayed time, starting around 6 months after diagnosis, to allow for a comparison between the two groups. Following completion of the exerise programme: * Half of participants will receive extra support to help them continue to exercise * The other half will not receive any additional support * All patients will be reviewed 1 year following the completion of their exercise programme to monitor their ongoing exercise levels.

Ages 18 Years+1 location
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RECRUITINGNo updates in a whileNCT06941025

Maternal and Postnatal Outcomes Study (MOS): A Global Observational Registry Assessing the Safety of Elfabrio® in Women With Fabry Disease and Their Infants During Pregnancy and Breastfeeding

Intervention: Not applicable- observational study

Fabry DiseasePregnancyPregnancy Complications

The goal of this observational registry is to evaluate the safety and outcomes of pregnancy and lactation in women with Fabry disease who are exposed to pegunigalsidase alfa within 30 days prior to conception and/or during pregnancy and lactation. The main objectives are to: * Assess pregnancy outcomes, including maternal and infant health. * Evaluate the occurrence of congenital malformations and other neonatal outcomes. This is a global, decentralized, single-arm, prospective and retrospective registry planned to enroll participants over a 10-year period. Eligible patients may be enrolled by their physician or may self-enroll, where permitted by local regulations. Data will be collected through a secure web-based platform, allowing patients and physicians to enter information via electronic case report forms (eCRFs). Pregnancy and clinical outcomes will be documented throughout pregnancy and up to 12 months post-birth. Data from self-enrolled patients will be confirmed by their primary care or attending physician. This registry is observational and does not impact clinical care or treatment decisions.

Ages not specified5 locations
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RECRUITINGPHASE2, PHASE3No updates in a whileNCT05710692

Study to Evaluate the Safety, PK, PD, and Efficacy of PRX-102 in Japanese Patients With Fabry Disease

Intervention: PRX-102 1 mg/kg every 2 weeks, PRX-102 2 mg/kg every 4 weeks

The aim of this study is to evaluate the safety and efficacy of pegunigalsidase alfa in Japanese patients (adults and adolescents) affected by Fabry disease. It is planned of a total of approximately 16 male and female Fabry disease patients between the ages of 13 and 70 years to be part of the study. The study is conducted in Japan.

Ages 13 Years - 70 Years10 locations
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Chiesi Farmaceutici FDA-Approved Drugs (9)

Medications developed or marketed by Chiesi Farmaceutici that have received U.S. Food and Drug Administration approval. Drug data is sourced from the openFDA database and includes brand names, generic names, approval dates, and matched rare disease indications. Where a drug treats a condition covered by Trial Friend, the disease name links directly to that disease page.

Drug NameBrand NameRare DiseasesApproval Date
TOBRAMYCIN
Aminoglycoside Antibacterial [EPC]
BETHKIS
respiratory (inhalation)
Oct 12, 2012
PEGUNIGALSIDASE ALFA
Hydrolytic Lysosomal Neutral Glycosphingolipid-specific Enzyme [EPC]
ELFABRIO
intravenous
May 9, 2023
DEFERIPRONE
Iron Chelator [EPC]
FERRIPROX
oral
Oct 14, 2011
BIRCH TRITERPENESFILSUVEZ
topical
Dec 18, 2023
LOMITAPIDE MESYLATEJuxtapid
oral
Dec 21, 2012

Chiesi Farmaceutici Trial Locations

Chiesi Farmaceutici clinical trials are running at 66 sites in 12 countries. Click any country to drill down by state, city, and individual research facility. Proximity to a trial site is one of the most important factors in deciding whether to participate.

United States
21▼
Japan
16▼
Italy
8▼
United Kingdom
7▼
Spain
4▼
France
3▼
Germany
2▼
Greece
1▼
North Macedonia
1▼
Austria
1▼
Norway
1▼
Slovenia
1▼

Rare Disease Focus Areas (13)

Diseases targeted by Chiesi Farmaceutici's clinical trial and drug development programs

AcromegalyEndocrine & Hormonal

Acromegaly is a rare hormonal disorder caused by excessive growth hormone production, typically from a pituitary adenoma, resulting in abnormal growth of hands, feet, and facial features. It also caus...

Prevalence: Approximately 50-130 cases per million people; estimated 25,000-30,000 people in the United States with about 3,000 new cases diagnosed per year
Alpha-1 Antitrypsin DeficiencyPulmonary & Respiratory

Alpha-1 antitrypsin deficiency is a genetic disorder affecting the lungs and liver, caused by insufficient production of the protective enzyme alpha-1 antitrypsin. Without adequate protection, neutrop...

Prevalence: 1 in 2,500 to 3,500 people; affects approximately 100,000 Americans
Cystic FibrosisPulmonary & Respiratory

Cystic fibrosis is an autosomal recessive genetic disorder affecting the CFTR protein, which normally regulates chloride transport. Defective CFTR causes thick, sticky secretions in the lungs and dige...

Prevalence: About 30,000 people in the U.S.; 1 in 2,500 to 3,500 births among Caucasians
Epidermolysis BullosaDermatologic

Epidermolysis bullosa is a group of rare genetic blistering disorders caused by mutations affecting proteins anchoring the epidermis to the dermis. Fragile skin blisters and erodes with minimal trauma...

Prevalence: 1 in 50,000 births; approximately 25,000-30,000 Americans affected
Fabry DiseaseMetabolic & Lysosomal

Fabry disease is a rare inherited lysosomal storage disorder where a missing enzyme causes fatty substances called globotriaosylceramide to accumulate in cells throughout the body. This buildup damage...

Prevalence: 1 in 40,000 to 60,000 males; higher in females when accounting for carrier status
Familial Chylomicronemia SyndromeMetabolic & Lysosomal

Familial Chylomicronemia Syndrome is a rare inherited metabolic disorder where the body cannot break down certain fats (triglycerides) normally, causing dangerously high blood fat levels. People with ...

Prevalence: 1 to 2 per 1,000,000 people globally

Patient Resources

Organizations and resources related to Chiesi Farmaceutici's rare disease focus areas

Frequently Asked Questions About Chiesi Farmaceutici

Common questions about Chiesi Farmaceutici's rare disease programs, clinical trials, and treatments.