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All 158 Sickle Cell Disease trials and their US sites
Enter your ZIP code above to sort them by how far their nearest open site is from you.
- ATHN Transcends: A Natural History Study of Non-Neoplastic Hematologic DisordersMost sites in California, Ohio and FloridaRecruitingAmerican Thrombosis and Hemostasis Network76US sites
31 states - A Study to Evaluate How Well Etavopivat Works in People With Sickle Cell DiseaseMost sites in New York, California and North CarolinaRecruitingPhase 3Ages 12+Novo Nordisk A/S44US sites
24 states - A Phase 2/3 Study of Osivelotor in Adult and Adolescent Participants With SCDMost sites in South Carolina, North Carolina and FloridaRecruitingPhase 2/3Ages 12+Pfizer35US sites
13 states - Comparing the Effectiveness of Matched Related Donor Hematopoietic Stem Cell Transplantation to Disease Modifying Therapy in Pediatric Patients With Sickle Cell DiseaseMost sites in New York, North Carolina and TexasRecruitingAges 3-20University of Rochester31US sites
16 states - The Efficacy and Safety of Rilzabrutinib in Participants Aged 10 to 65 Years With Sickle-cell DiseaseMost sites in California, Florida and New YorkRecruitingPhase 3Ages 10-65Sanofi21US sites
17 states - Safety, Efficacy, and Pharmacokinetics of CSL889 in Adults and Adolescents With Sickle Cell Disease During Vaso-Occlusive CrisisMost sites in California, Florida and MichiganRecruitingPhase 2Ages 12+CSL Behring19US sites
13 states - A Study to Evaluate BMS-986470 in Healthy Volunteers and Participants With Sickle Cell DiseaseMost sites in Pennsylvania, California and MassachusettsRecruitingPhase 1/2Ages 18+Bristol-Myers Squibb18US sites
13 states - A Long-term Follow-up Study in Patients Who Received BEAM-101Most sites in Ohio, Tennessee and AlabamaRecruitingAges 14-37Beam Therapeutics17US sites
15 states - A Study to Investigate the Efficacy and Safety of Crizanlizumab (5 mg/kg) Compared With Placebo in Adolescent and Adult Sickle Cell Disease Patients Who Experience Frequent Vaso-Occlusive Crises (SPARKLE)Most sites in Georgia, North Carolina and TexasRecruitingPhase 3Ages 12-100Novartis Pharmaceuticals16US sites
13 states - Peer Support for Adolescents and Emerging Adults With Sickle Cell PainMost sites in New York, North Carolina and PennsylvaniaRecruitingAges 16-39University of Pittsburgh14US sites
11 states - Safety of Anumigilimab (CSL324) in Adults With Sickle Cell Disease (SCD)Most sites in New York, Arkansas and CaliforniaRecruitingPhase 2Ages 18+CSL Behring14US sites
12 states - A Phase 1b, Open-Label Study of DISC-3405 in Participants With Sickle Cell Disease (SCD)Most sites in Georgia, North Carolina and AlabamaRecruitingPhase 1Ages 18+Disc Medicine11US sites
9 states - A Research Study Looking at Long-term Treatment With Etavopivat in People With Sickle Cell Disease or ThalassaemiaMost sites in California, New York and North CarolinaRecruitingPhase 3Ages 2+Novo Nordisk A/S11US sites
7 states - Recruitment and Engagement in Care to Impact Practice Enhancement (RECIPE) for Sickle Cell DiseaseMost sites in Alabama, Arizona and CaliforniaRecruitingAges 18+RTI International9US sites
9 states - A Phase I/II Study of ITU512 in Healthy Participants and Patients With Sickle Cell DiseaseMost sites in North Carolina, Alabama and MassachusettsRecruitingPhase 1/2Ages 12-55Novartis Pharmaceuticals8US sites
7 states - Achieving Understanding of the Natural History of Sickle Cell Trait (AUNT)Most sites in North Carolina, Alabama and DelawareRecruitingAges 18+National Alliance for Sickle Cell Centers8US sites
6 states - A Study of Immune Suppression Treatment for People With Sickle Cell Disease or β-Thalassemia Who Are Going to Receive an Allogeneic Hematopoietic Cell Transplantation (HCT)Most sites in New Jersey and New YorkRecruitingPhase 2Ages 2-50Memorial Sloan Kettering Cancer Center6US sites
2 states - Gene Correction in Autologous CD34+ Hematopoietic Stem Cells (HbS to HbA) to Treat Severe Sickle Cell DiseaseMost sites in California, New York and MissouriRecruitingPhase 1/2Ages 12-50Kamau Therapeutics6US sites
4 states - Zinc Supplementation in Sickle Cell Disease: A Precursor to the Think Zinc for Bones TrialMost sites in Pennsylvania, California and North CarolinaRecruitingPhase 2Ages 15-40University of California, San Francisco6US sites
5 states - A Study to Investigate the Effect of Mitapivat on Transfusion Burden in Subjects With Sickle Cell Disease (SCD)Most sites in Indiana, Michigan and MississippiRecruitingPhase 3Ages 12+Agios Pharmaceuticals5US sites
5 states
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Who runs the Sickle Cell Disease trials in the US, and what stage they are in
Of the 120 Sickle Cell Disease trials with a US site, 10 are in Phase 3, the last stage before a company can ask the FDA for approval. Earlier Phase 1 or 2 tests of safety and dosing make up 44 of them. Phase 4 studies of an already approved treatment make up 4. The remaining 62 have no drug phase, such as studies that follow people over time or test a device or a way of giving care. Companies run 19 of them, and universities, hospitals, foundations and government groups run 101. The sponsors with the most are St. Jude Children's Research Hospital (13), National Heart, Lung, and Blood Institute (NHLBI) (6) and Children's Hospital Medical Center, Cincinnati (4). The most recently listed one first appeared on ClinicalTrials.gov on November 10, 2026.
Sickle Cell Disease trials in the US, state by state
Of the 120 Sickle Cell Disease trials with a US site, 82 accept children under 18. Their open sites are in 38 states and Washington, DC, most often Georgia, New York and North Carolina. A trial counts once in each state where it has an open site, and some trials accept both children and adults.
Show the other 29 states
US hospitals running the most Sickle Cell Disease trials
Centers that run trials for a rare condition often see more people with it than most clinics do, so this list can also help you find doctors who know Sickle Cell Disease.
- St. Jude Children's Research HospitalMemphis, Tennessee14 trials
- National Institutes of Health Clinical CenterBethesda, Maryland10 trials
- Boston Children's HospitalBoston, Massachusetts8 trials
- Children's Hospital of PhiladelphiaPhiladelphia, Pennsylvania7 trials
- Cincinnati Children's Hospital Medical CenterCincinnati, Ohio6 trials
- University of Alabama at BirminghamBirmingham, Alabama6 trials
- Children's Healthcare of AtlantaAtlanta, Georgia5 trials
- Children's National HospitalWashington D.C., District of Columbia5 trials
- Connecticut Children's Medical CenterHartford, Connecticut5 trials
- Duke University Medical CenterDurham, North Carolina5 trials
Help getting to a Sickle Cell Disease trial far from home
Ask the study team whether the trial pays back travel, parking and hotel costs, because many sponsors do. The FDA's guidance on paying research volunteers says paying back these costs does not count as pressuring someone to join.
These nonprofits also help patients reach care, and each one sets its own rules.
- Mercy Medical Angels
- Pays for gas cards, ground rides and airline tickets anywhere in the US, and it lists clinical trials as a reason to travel. Household income at or below 300% of the federal poverty guidelines, and usually a trip of 50 miles or more each way.
- Air Charity Network
- Volunteer pilots in all 50 states fly patients for free in small private planes, and members also fly people taking part in clinical trials. You must be able to walk and sit upright for the flight, show financial need and have a backup plan if weather cancels it.
- Ronald McDonald House
- Gives families a room near the hospital while a child gets care, through 394 House programs around the world. Families of a sick child, with rules set by each local chapter.
- Healthcare Hospitality Network
- Keeps a map of hospitality houses near hospitals, and most member houses charge little or nothing to patients and families. Each house sets its own rules, so check with the house near your study site.
Program details were checked on each program's website on October 24, 2026.
Questions about finding a Sickle Cell Disease trial near you
Are there Sickle Cell Disease clinical trials near me?
As of November 13, 2026, 158 Sickle Cell Disease clinical trials are recruiting now and 40 are not yet recruiting. In the US, 120 of them have at least 1 open site, across 38 states and Washington, DC. Enter your ZIP code on this page to rank every one of them by the distance to its closest open site, with the sites shown on a map.
Which states have Sickle Cell Disease clinical trial sites?
Recruiting Sickle Cell Disease trials list open sites in 38 states and Washington, DC. Georgia, Ohio and New York have the most, and the table on this page lists every state.
Are there Sickle Cell Disease trials for children near me?
Of the 120 Sickle Cell Disease trials with a US site, 82 accept children under 18. Their open sites are in 38 states and Washington, DC, most often Georgia, New York and North Carolina. Each trial sets its own age limits, so check the ages listed on a trial before you contact it.
Who pays for travel to a Sickle Cell Disease clinical trial?
Many trial sponsors pay back travel, parking and hotel costs, so ask the study team before you rule out a far-away site. The FDA's guidance says paying back these costs does not count as pressuring someone to join. Charities such as Mercy Medical Angels and Air Charity Network can also help with rides and flights.
What if there is no Sickle Cell Disease trial near me?
Some trials send staff to your home or use a local lab, so fewer visits happen at the study site. You can also sign up on this page to get an email when a Sickle Cell Disease trial opens a new site or changes status.
How is the distance to a trial site measured?
Distances are straight-line miles from the center of your ZIP code to each study site's listed location, not driving distance. Your browser looks up the ZIP code's coordinates with a free map service, Zippopotam.us, and the ZIP code is never sent to or stored by Trial Friend.
FDA-approved for Sickle Cell Disease: Adakveo (crizanlizumab), Casgevy (exagamglogene autotemcel), Droxia (hydroxyurea), Endari (l-glutamine), Lyfgenia (lovotibeglogene autotemcel), Ferriprox (deferiprone).
Clinical trials near you for related conditions
Source: ClinicalTrials.gov, trials with status Recruiting or Not yet recruiting. Refreshed every 6 hours; counts as of November 13, 2026. Sites that ClinicalTrials.gov lists as closed or withdrawn are left out. Children means the trial's age group includes people under 18.