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All 11 Homozygous Familial Hypercholesterolemia trials and their US sites
Enter your ZIP code above to sort them by how far their nearest open site is from you.
- A Safety and Tolerability Trial Evaluating CTX310 in Participants With Refractory DyslipidemiasMost sites in Florida, North Carolina and New YorkRecruitingPhase 1Ages 18-75CRISPR Therapeutics8US sites
4 states - HoFH, the International Clinical Collaborators RegistryOnly in PennsylvaniaRecruitingUniversity of Pennsylvania1US site
- Long-term Safety and Tolerability of Inclisiran in Participants With HeFH or HoFH Who Have Completed the Pediatric ORION-16, ORION-13, ORION-20, or ORION-19 StudiesOnly in UtahRecruitingPhase 3Ages 2-100Novartis Pharmaceuticals1US site
- Study of Zodasiran in Adolescent Participants With Homozygous Familial HypercholesterolemiaOnly in MissouriRecruitingPhase 3Ages 12-17Arrowhead Pharmaceuticals1US site
- The ORIGIN-FH StudyOnly in WisconsinRecruitingAges 18+University of Wisconsin, Madison1US site
- The Rogosin Institute Homozygous Familial Hypercholesterolemia RepositoryOnly in New YorkRecruitingThe Rogosin Institute1US site
- A Dose-exploration Study of EDP167 in HoFHRecruitingPhase 2Ages 18+Eddingpharm (Zhuhai) Co.No US site yet
- Assessing the Impact of Intensification of Lipid Lowering Therapy With Guidelines-based Evinacumab Administration on Coronary Plaque Volumes Measured by Coronary Computed Tomography Angiography (CCTA) in Patients With Homozygous Familial Hypercholesterolemia (HoFH)RecruitingAges 12+Fondazione SISA (Societa Italiana per lo Studio della Arteriosclerosi)No US site yet
- Early Detection of Familial Hypercholesterolemia in ChildrenRecruitingAges 2-18Institut Investigacio Sanitaria Pere VirgiliNo US site yet
- NGGT006 Gene Therapy for Homozygous Familial HypercholesterolemiaRecruitingEarly Phase 1Ages 12-55First Affiliated Hospital Xi'an Jiaotong UniversityNo US site yet
- Phase II Clinical Trial to Evaluate the Efficacy and Safety of SYH2070 Injection in Participants With Homozygous Familial HypercholesterolemiaRecruitingPhase 2Ages 18+CSPC Zhongnuo Pharmaceutical (Shijiazhuang) Co.No US site yet
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Who runs the Homozygous Familial Hypercholesterolemia trials in the US, and what stage they are in
Of the 6 Homozygous Familial Hypercholesterolemia trials with a US site, 2 are in Phase 3, the last stage before a company can ask the FDA for approval. One more is an earlier Phase 1 or 2 test of safety and dosing. The remaining 3 have no drug phase, such as studies that follow people over time or test a device or a way of giving care. Companies run 3 of them, and universities, hospitals, foundations and government groups run 3. The most recently listed one first appeared on ClinicalTrials.gov on March 24, 2026.
Homozygous Familial Hypercholesterolemia trials in the US, state by state
Of the 6 Homozygous Familial Hypercholesterolemia trials with a US site, 4 accept children under 18. Their open sites are in 4 states, most often Missouri, New York and Pennsylvania. A trial counts once in each state where it has an open site, and some trials accept both children and adults.
US hospitals running the most Homozygous Familial Hypercholesterolemia trials
Centers that run trials for a rare condition often see more people with it than most clinics do, so this list can also help you find doctors who know Homozygous Familial Hypercholesterolemia.
- Duke Early Phase Clinical ResearchDurham, North Carolina1 trial
- Flourish OrlandoOrlando, Florida1 trial
- Integrity Clinical ResearchHialeah, Florida1 trial
- Jacksonville Center for Clinical ResearchJacksonville, Florida1 trial
- Oregon Health & Science University (OHSU)Portland, Oregon1 trial
- Peters Medical ResearchHigh Point, North Carolina1 trial
- Primary Childrens Medical CenterSalt Lake City, Utah1 trial
- United Medical ResearchPort Orange, Florida1 trial
- University of PennsylvaniaPhiladelphia, Pennsylvania1 trial
- University of RochesterRochester, New York1 trial
Help getting to a Homozygous Familial Hypercholesterolemia trial far from home
Ask the study team whether the trial pays back travel, parking and hotel costs, because many sponsors do. The FDA's guidance on paying research volunteers says paying back these costs does not count as pressuring someone to join.
These nonprofits also help patients reach care, and each one sets its own rules.
- Mercy Medical Angels
- Pays for gas cards, ground rides and airline tickets anywhere in the US, and it lists clinical trials as a reason to travel. Household income at or below 300% of the federal poverty guidelines, and usually a trip of 50 miles or more each way.
- Air Charity Network
- Volunteer pilots in all 50 states fly patients for free in small private planes, and members also fly people taking part in clinical trials. You must be able to walk and sit upright for the flight, show financial need and have a backup plan if weather cancels it.
- Ronald McDonald House
- Gives families a room near the hospital while a child gets care, through 394 House programs around the world. Families of a sick child, with rules set by each local chapter.
- Healthcare Hospitality Network
- Keeps a map of hospitality houses near hospitals, and most member houses charge little or nothing to patients and families. Each house sets its own rules, so check with the house near your study site.
Program details were checked on each program's website on October 24, 2026.
Questions about finding a Homozygous Familial Hypercholesterolemia trial near you
Are there Homozygous Familial Hypercholesterolemia clinical trials near me?
As of November 13, 2026, 11 Homozygous Familial Hypercholesterolemia clinical trials are recruiting now and 1 is not yet recruiting. In the US, 6 of them have at least 1 open site, across 8 states. Enter your ZIP code on this page to rank every one of them by the distance to its closest open site, with the sites shown on a map.
Which states have Homozygous Familial Hypercholesterolemia clinical trial sites?
Recruiting Homozygous Familial Hypercholesterolemia trials list open sites in Florida, Missouri, New York, North Carolina, Oregon, Pennsylvania, Utah and Wisconsin.
Are there Homozygous Familial Hypercholesterolemia trials for children near me?
Of the 6 Homozygous Familial Hypercholesterolemia trials with a US site, 4 accept children under 18. Their open sites are in 4 states, most often Missouri, New York and Pennsylvania. Each trial sets its own age limits, so check the ages listed on a trial before you contact it.
Who pays for travel to a Homozygous Familial Hypercholesterolemia clinical trial?
Many trial sponsors pay back travel, parking and hotel costs, so ask the study team before you rule out a far-away site. The FDA's guidance says paying back these costs does not count as pressuring someone to join. Charities such as Mercy Medical Angels and Air Charity Network can also help with rides and flights.
What if there is no Homozygous Familial Hypercholesterolemia trial near me?
Some trials send staff to your home or use a local lab, so fewer visits happen at the study site. You can also sign up on this page to get an email when a Homozygous Familial Hypercholesterolemia trial opens a new site or changes status.
How is the distance to a trial site measured?
Distances are straight-line miles from the center of your ZIP code to each study site's listed location, not driving distance. Your browser looks up the ZIP code's coordinates with a free map service, Zippopotam.us, and the ZIP code is never sent to or stored by Trial Friend.
FDA-approved for Homozygous Familial Hypercholesterolemia: Atorvastatin Calcium (atorvastatin calcium, film coated), Caduet (amlodipine and atorvastatin), Evkeeza (evinacumab-dgnb), Juxtapid (lomitapide mesylate), Leqvio (inclisiran), Praluent (alirocumab), Repatha (evolocumab), Rosuvastatin calcium and 3 more on the disease page.
Clinical trials near you for related conditions
Source: ClinicalTrials.gov, trials with status Recruiting or Not yet recruiting. Refreshed every 6 hours; counts as of November 13, 2026. Sites that ClinicalTrials.gov lists as closed or withdrawn are left out. Children means the trial's age group includes people under 18.