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Alpha-1 Antitrypsin Deficiency Clinical Trials Near Me

As of November 13, 2026, 17 Alpha-1 Antitrypsin Deficiency clinical trials are recruiting now and 3 are not yet recruiting. In the US, 10 of them have at least 1 open site, across 13 states. Enter your ZIP code below to see which are closest to you.

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All 17 Alpha-1 Antitrypsin Deficiency trials and their US sites

Enter your ZIP code above to sort them by how far their nearest open site is from you.

  1. A Non-inferiority Pharmacokinetic and Safety/Tolerability Study of Two Different Doses of Weekly SC Alpha1-PI 15% Compared With Corresponding Standard IV Alpha1-PI in Participants With Alpha1-Antitrypsin Deficiency (AATD)
    Most sites in Arizona, Florida and Alabama
    RecruitingPhase 3Ages 18-80Grifols Therapeutics
    9US sites
    7 states
  2. A Study of TSRA-196 in Adults With PiZZ Alpha-1 Antitrypsin Deficiency (AATD)
    Most sites in Florida, Massachusetts and Minnesota
    RecruitingPhase 1/2Ages 18-70Tessera Therapeutics
    5US sites
    5 states
  3. PiMZ Longitudinal Cohort (PiMZ Logic)
    Most sites in Alabama, California and Colorado
    RecruitingAges 18+Columbia University
    5US sites
    5 states
  4. A Study of KB408 for the Treatment of Alpha-1 Antitrypsin Deficiency
    Most sites in Florida, South Carolina and Texas
    RecruitingPhase 1Ages 18-70Krystal Biotech
    3US sites
    3 states
  5. A Study to Evaluate the Safety and Efficacy of BEAM-302 in Adult Patients With Alpha-1 Antitrypsin Deficiency (AATD)
    Most sites in Alabama, Massachusetts and South Carolina
    RecruitingPhase 1/2Ages 18-75Beam Therapeutics
    3US sites
    3 states
  6. Alpha-1 Research Registry
    Only in Florida
    RecruitingAlpha-1 Foundation
    1US site
  7. Gene Therapy for Alpha 1- Antitrypsin Deficiency
    Only in New York
    RecruitingPhase 1Ages 18-70Weill Medical College of Cornell University
    1US site
  8. Genetic Variation in IgG in Alpha 1 Antitrypsin Deficiency
    Only in Alabama
    RecruitingPhase 4Ages 19+University of Alabama at Birmingham
    1US site
  9. Lung Disease and Its Affect on the Work of White Blood Cells in the Lungs
    Only in Florida
    RecruitingAges 18+University of Florida
    1US site
  10. The Alpha-1 Foundation's and University of Florida's Alpha-1 Coded Testing (ACT) Study
    Only in Florida
    RecruitingUniversity of Florida
    1US site
  11. A Phase 1b/2a, Open-label Single Ascending Doses and Multiple Ascending Doses Study in Participants With Pi*ZZ AATD
    RecruitingPhase 1/2Ages 18-70Wave Life Sciences USA
    No US site yet
  12. A Study of AIR-001 in Adults With Alpha-1 Antitrypsin Deficiency (AATD)
    RecruitingPhase 1Ages 18-74AIRNA
    No US site yet
  13. A Trial Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of CTX460 in Adults With Emphysema Associated With Severe Alpha-1 Antitrypsin Deficiency (AATD)
    RecruitingPhase 1/2Ages 18-75CRISPR Therapeutics
    No US site yet
  14. Chronic Respiratory Disease Participant Engagement Study
    RecruitingAges 18+Richmond Research Institute
    No US site yet
  15. Czech AATD Registry
    RecruitingThomayer University Hospital
    No US site yet
  16. Development of a Prediction Score for the Occurrence of Death or Lung Transplantation in Patients With Emphysema Secondary to Alpha-1-anti-tripsin Deficiency
    RecruitingAges 18+University Hospital, Bordeaux
    No US site yet
  17. Screening for Alpha-1 Antitrypsin Deficiency in Patients With Airway Obstruction
    RecruitingAges 18+Muğla Sıtkı Koçman University
    No US site yet
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Who runs the Alpha-1 Antitrypsin Deficiency trials in the US, and what stage they are in

Of the 10 Alpha-1 Antitrypsin Deficiency trials with a US site, 1 is in Phase 3, the last stage before a company can ask the FDA for approval. Earlier Phase 1 or 2 tests of safety and dosing make up 4 of them. One is a Phase 4 study of an already approved treatment. The remaining 4 have no drug phase, such as studies that follow people over time or test a device or a way of giving care. Companies run 4 of them, and universities, hospitals, foundations and government groups run 6. University of Florida runs the most, with 2. The most recently listed one first appeared on ClinicalTrials.gov on April 29, 2026.

Alpha-1 Antitrypsin Deficiency trials in the US, state by state

Of the 10 Alpha-1 Antitrypsin Deficiency trials with a US site, 2 accept children under 18. Their open sites are in Florida. A trial counts once in each state where it has an open site, and some trials accept both children and adults.

StateTrialsChildrenAdultsCities with the most
Florida626Gainesville (4), Coral Gables (1), Jacksonville (1), plus 1 more
Alabama404Birmingham (4)
South Carolina404Charleston (4)
Massachusetts202Boston (2)
Minnesota202Rochester (2)
New York202New York (2)
Texas202Dallas (1), The Woodlands (1)
Arizona101Phoenix (1), Scottsdale (1)
California101Los Angeles (1)
Colorado101Denver (1)
Show the other 3 states
Illinois101Chicago (1)
Ohio101Cleveland (1)
Washington101Seattle (1)

US hospitals running the most Alpha-1 Antitrypsin Deficiency trials

Centers that run trials for a rare condition often see more people with it than most clinics do, so this list can also help you find doctors who know Alpha-1 Antitrypsin Deficiency.

  1. Clinical Study CenterBoston, Massachusetts2 trials
  2. Clinical Study CenterCharleston, South Carolina2 trials
  3. University of Alabama at BirminghamBirmingham, Alabama2 trials
  4. Alpha-1 FoundationCoral Gables, Florida1 trial
  5. Clinical Study CenterJacksonville, Florida1 trial
  6. Clinical Study CenterRochester, Minnesota1 trial
  7. Clinical Study CenterSeattle, Washington1 trial
  8. Clinical Study CenterBirmingham, Alabama1 trial
  9. Columbia University Irving Medical CenterNew York, New York1 trial
  10. Medical University of South CarolinaCharleston, South Carolina1 trial

Help getting to an Alpha-1 Antitrypsin Deficiency trial far from home

Ask the study team whether the trial pays back travel, parking and hotel costs, because many sponsors do. The FDA's guidance on paying research volunteers says paying back these costs does not count as pressuring someone to join.

These nonprofits also help patients reach care, and each one sets its own rules.

Mercy Medical Angels
Pays for gas cards, ground rides and airline tickets anywhere in the US, and it lists clinical trials as a reason to travel. Household income at or below 300% of the federal poverty guidelines, and usually a trip of 50 miles or more each way.
Air Charity Network
Volunteer pilots in all 50 states fly patients for free in small private planes, and members also fly people taking part in clinical trials. You must be able to walk and sit upright for the flight, show financial need and have a backup plan if weather cancels it.
Ronald McDonald House
Gives families a room near the hospital while a child gets care, through 394 House programs around the world. Families of a sick child, with rules set by each local chapter.
Healthcare Hospitality Network
Keeps a map of hospitality houses near hospitals, and most member houses charge little or nothing to patients and families. Each house sets its own rules, so check with the house near your study site.

Program details were checked on each program's website on October 24, 2026.

Questions about finding an Alpha-1 Antitrypsin Deficiency trial near you

Are there Alpha-1 Antitrypsin Deficiency clinical trials near me?

As of November 13, 2026, 17 Alpha-1 Antitrypsin Deficiency clinical trials are recruiting now and 3 are not yet recruiting. In the US, 10 of them have at least 1 open site, across 13 states. Enter your ZIP code on this page to rank every one of them by the distance to its closest open site, with the sites shown on a map.

Which states have Alpha-1 Antitrypsin Deficiency clinical trial sites?

Recruiting Alpha-1 Antitrypsin Deficiency trials list open sites in 13 states. Florida, Alabama and South Carolina have the most, and the table on this page lists every state.

Are there Alpha-1 Antitrypsin Deficiency trials for children near me?

Of the 10 Alpha-1 Antitrypsin Deficiency trials with a US site, 2 accept children under 18. Their open sites are in Florida. Each trial sets its own age limits, so check the ages listed on a trial before you contact it.

Who pays for travel to an Alpha-1 Antitrypsin Deficiency clinical trial?

Many trial sponsors pay back travel, parking and hotel costs, so ask the study team before you rule out a far-away site. The FDA's guidance says paying back these costs does not count as pressuring someone to join. Charities such as Mercy Medical Angels and Air Charity Network can also help with rides and flights.

What if there is no Alpha-1 Antitrypsin Deficiency trial near me?

Some trials send staff to your home or use a local lab, so fewer visits happen at the study site. You can also sign up on this page to get an email when an Alpha-1 Antitrypsin Deficiency trial opens a new site or changes status.

How is the distance to a trial site measured?

Distances are straight-line miles from the center of your ZIP code to each study site's listed location, not driving distance. Your browser looks up the ZIP code's coordinates with a free map service, Zippopotam.us, and the ZIP code is never sent to or stored by Trial Friend.

FDA-approved for Alpha-1 Antitrypsin Deficiency: Prolastin-C (alpha-1 proteinase inhibitor (human)).

Source: ClinicalTrials.gov, trials with status Recruiting or Not yet recruiting. Refreshed every 6 hours; counts as of November 13, 2026. Sites that ClinicalTrials.gov lists as closed or withdrawn are left out. Children means the trial's age group includes people under 18.