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All 17 Alpha-1 Antitrypsin Deficiency trials and their US sites
Enter your ZIP code above to sort them by how far their nearest open site is from you.
- A Non-inferiority Pharmacokinetic and Safety/Tolerability Study of Two Different Doses of Weekly SC Alpha1-PI 15% Compared With Corresponding Standard IV Alpha1-PI in Participants With Alpha1-Antitrypsin Deficiency (AATD)Most sites in Arizona, Florida and AlabamaRecruitingPhase 3Ages 18-80Grifols Therapeutics9US sites
7 states - A Study of TSRA-196 in Adults With PiZZ Alpha-1 Antitrypsin Deficiency (AATD)Most sites in Florida, Massachusetts and MinnesotaRecruitingPhase 1/2Ages 18-70Tessera Therapeutics5US sites
5 states - PiMZ Longitudinal Cohort (PiMZ Logic)Most sites in Alabama, California and ColoradoRecruitingAges 18+Columbia University5US sites
5 states - A Study of KB408 for the Treatment of Alpha-1 Antitrypsin DeficiencyMost sites in Florida, South Carolina and TexasRecruitingPhase 1Ages 18-70Krystal Biotech3US sites
3 states - A Study to Evaluate the Safety and Efficacy of BEAM-302 in Adult Patients With Alpha-1 Antitrypsin Deficiency (AATD)Most sites in Alabama, Massachusetts and South CarolinaRecruitingPhase 1/2Ages 18-75Beam Therapeutics3US sites
3 states - Alpha-1 Research RegistryOnly in FloridaRecruitingAlpha-1 Foundation1US site
- Gene Therapy for Alpha 1- Antitrypsin DeficiencyOnly in New YorkRecruitingPhase 1Ages 18-70Weill Medical College of Cornell University1US site
- Genetic Variation in IgG in Alpha 1 Antitrypsin DeficiencyOnly in AlabamaRecruitingPhase 4Ages 19+University of Alabama at Birmingham1US site
- Lung Disease and Its Affect on the Work of White Blood Cells in the LungsOnly in FloridaRecruitingAges 18+University of Florida1US site
- The Alpha-1 Foundation's and University of Florida's Alpha-1 Coded Testing (ACT) StudyOnly in FloridaRecruitingUniversity of Florida1US site
- A Phase 1b/2a, Open-label Single Ascending Doses and Multiple Ascending Doses Study in Participants With Pi*ZZ AATDRecruitingPhase 1/2Ages 18-70Wave Life Sciences USANo US site yet
- A Study of AIR-001 in Adults With Alpha-1 Antitrypsin Deficiency (AATD)RecruitingPhase 1Ages 18-74AIRNANo US site yet
- A Trial Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of CTX460 in Adults With Emphysema Associated With Severe Alpha-1 Antitrypsin Deficiency (AATD)RecruitingPhase 1/2Ages 18-75CRISPR TherapeuticsNo US site yet
- Chronic Respiratory Disease Participant Engagement StudyRecruitingAges 18+Richmond Research InstituteNo US site yet
- Czech AATD RegistryRecruitingThomayer University HospitalNo US site yet
- Development of a Prediction Score for the Occurrence of Death or Lung Transplantation in Patients With Emphysema Secondary to Alpha-1-anti-tripsin DeficiencyRecruitingAges 18+University Hospital, BordeauxNo US site yet
- Screening for Alpha-1 Antitrypsin Deficiency in Patients With Airway ObstructionRecruitingAges 18+Muğla Sıtkı Koçman UniversityNo US site yet
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Who runs the Alpha-1 Antitrypsin Deficiency trials in the US, and what stage they are in
Of the 10 Alpha-1 Antitrypsin Deficiency trials with a US site, 1 is in Phase 3, the last stage before a company can ask the FDA for approval. Earlier Phase 1 or 2 tests of safety and dosing make up 4 of them. One is a Phase 4 study of an already approved treatment. The remaining 4 have no drug phase, such as studies that follow people over time or test a device or a way of giving care. Companies run 4 of them, and universities, hospitals, foundations and government groups run 6. University of Florida runs the most, with 2. The most recently listed one first appeared on ClinicalTrials.gov on April 29, 2026.
Alpha-1 Antitrypsin Deficiency trials in the US, state by state
Of the 10 Alpha-1 Antitrypsin Deficiency trials with a US site, 2 accept children under 18. Their open sites are in Florida. A trial counts once in each state where it has an open site, and some trials accept both children and adults.
Show the other 3 states
US hospitals running the most Alpha-1 Antitrypsin Deficiency trials
Centers that run trials for a rare condition often see more people with it than most clinics do, so this list can also help you find doctors who know Alpha-1 Antitrypsin Deficiency.
- Clinical Study CenterBoston, Massachusetts2 trials
- Clinical Study CenterCharleston, South Carolina2 trials
- University of Alabama at BirminghamBirmingham, Alabama2 trials
- Alpha-1 FoundationCoral Gables, Florida1 trial
- Clinical Study CenterJacksonville, Florida1 trial
- Clinical Study CenterRochester, Minnesota1 trial
- Clinical Study CenterSeattle, Washington1 trial
- Clinical Study CenterBirmingham, Alabama1 trial
- Columbia University Irving Medical CenterNew York, New York1 trial
- Medical University of South CarolinaCharleston, South Carolina1 trial
Help getting to an Alpha-1 Antitrypsin Deficiency trial far from home
Ask the study team whether the trial pays back travel, parking and hotel costs, because many sponsors do. The FDA's guidance on paying research volunteers says paying back these costs does not count as pressuring someone to join.
These nonprofits also help patients reach care, and each one sets its own rules.
- Mercy Medical Angels
- Pays for gas cards, ground rides and airline tickets anywhere in the US, and it lists clinical trials as a reason to travel. Household income at or below 300% of the federal poverty guidelines, and usually a trip of 50 miles or more each way.
- Air Charity Network
- Volunteer pilots in all 50 states fly patients for free in small private planes, and members also fly people taking part in clinical trials. You must be able to walk and sit upright for the flight, show financial need and have a backup plan if weather cancels it.
- Ronald McDonald House
- Gives families a room near the hospital while a child gets care, through 394 House programs around the world. Families of a sick child, with rules set by each local chapter.
- Healthcare Hospitality Network
- Keeps a map of hospitality houses near hospitals, and most member houses charge little or nothing to patients and families. Each house sets its own rules, so check with the house near your study site.
Program details were checked on each program's website on October 24, 2026.
Questions about finding an Alpha-1 Antitrypsin Deficiency trial near you
Are there Alpha-1 Antitrypsin Deficiency clinical trials near me?
As of November 13, 2026, 17 Alpha-1 Antitrypsin Deficiency clinical trials are recruiting now and 3 are not yet recruiting. In the US, 10 of them have at least 1 open site, across 13 states. Enter your ZIP code on this page to rank every one of them by the distance to its closest open site, with the sites shown on a map.
Which states have Alpha-1 Antitrypsin Deficiency clinical trial sites?
Recruiting Alpha-1 Antitrypsin Deficiency trials list open sites in 13 states. Florida, Alabama and South Carolina have the most, and the table on this page lists every state.
Are there Alpha-1 Antitrypsin Deficiency trials for children near me?
Of the 10 Alpha-1 Antitrypsin Deficiency trials with a US site, 2 accept children under 18. Their open sites are in Florida. Each trial sets its own age limits, so check the ages listed on a trial before you contact it.
Who pays for travel to an Alpha-1 Antitrypsin Deficiency clinical trial?
Many trial sponsors pay back travel, parking and hotel costs, so ask the study team before you rule out a far-away site. The FDA's guidance says paying back these costs does not count as pressuring someone to join. Charities such as Mercy Medical Angels and Air Charity Network can also help with rides and flights.
What if there is no Alpha-1 Antitrypsin Deficiency trial near me?
Some trials send staff to your home or use a local lab, so fewer visits happen at the study site. You can also sign up on this page to get an email when an Alpha-1 Antitrypsin Deficiency trial opens a new site or changes status.
How is the distance to a trial site measured?
Distances are straight-line miles from the center of your ZIP code to each study site's listed location, not driving distance. Your browser looks up the ZIP code's coordinates with a free map service, Zippopotam.us, and the ZIP code is never sent to or stored by Trial Friend.
FDA-approved for Alpha-1 Antitrypsin Deficiency: Prolastin-C (alpha-1 proteinase inhibitor (human)).
Clinical trials near you for related conditions
Source: ClinicalTrials.gov, trials with status Recruiting or Not yet recruiting. Refreshed every 6 hours; counts as of November 13, 2026. Sites that ClinicalTrials.gov lists as closed or withdrawn are left out. Children means the trial's age group includes people under 18.
