IgA Vasculitis with Nephritis Clinical Trials and Treatments

IgA vasculitis (formerly Henoch-Schönlein purpura) is a small-vessel immune complex vasculitis characterized by predominant IgA deposition in involved organs (kidneys, skin, GI tract). The condition presents with characteristic tetrad of palpable purpura (small red spots on lower extremities and buttocks), arthritis/arthralgias, abdominal pain, and glomerulonephritis, though not all features present in every patient. IgA-dominant glomerulonephritis develops in approximately 40-50% of patients with systemic disease; when kidney biopsy performed in all patients, IgA deposition found in ~100%.

The most common symptoms of IgA Vasculitis with Nephritis include Palpable purpura on lower extremities and buttocks, Arthritis and arthralgias, Glomerulonephritis with hematuria and proteinuria, Abdominal pain and GI bleeding, Renal dysfunction and hypertension, among others. About 3 to 27 new cases per 100,000 children each year; the most common vasculitis of childhood. Symptoms can range from mild to severe and may vary between individuals.

Trial Friend lists all active clinical trials for IgA Vasculitis with Nephritis from ClinicalTrials.gov, with eligibility criteria translated into plain English. Patients can filter by trial phase and recruitment status, search by location, and use the Match Me tool to score trials against their profile. Clinical trials are investigating immunomodulatory therapies targeting IgA production (BAFF inhibitors, complement inhibitors) and inflammation for IgA vasculitis, particularly for those with progressive glomerulonephritis. Supportive care with ACE inhibitors or ARBs to reduce proteinuria and blood pressure remains the foundation of therapy for all patients.

As of September 2026, Trial Friend's curated drug index does not include an FDA-approved treatment specific to IgA Vasculitis with Nephritis. The Treatments section of this page checks FDA drug labels live and lists any approved drug whose label names the condition, and the trials listed below cover the investigational options.

The exact cause of IgA Vasculitis with Nephritis is not fully understood. It is not caused by a single gene; inherited variants raise risk, and immune, environmental or other triggers are thought to set it off. IgA vasculitis (Henoch-Schönlein purpura) is an immune-complex vasculitis of unknown cause, often following an upper respiratory infection; no genetic test has a diagnostic role. About 3 to 27 new cases per 100,000 children each year; the most common vasculitis of childhood. Research is ongoing to better understand the disease mechanism.

No single gene test diagnoses IgA Vasculitis with Nephritis. The diagnosis rests on clinical findings and laboratory or imaging results; genetic variants shift risk rather than cause the disease. IgA vasculitis (Henoch-Schönlein purpura) is an immune-complex vasculitis of unknown cause, often following an upper respiratory infection; no genetic test has a diagnostic role.

Some trials collect genetic samples for research or check specific risk markers. The Genetic Testing section of this page shows any tests listed in the NIH Genetic Testing Registry, which for this condition are usually research or risk-marker tests rather than diagnostic ones.

Eligibility for IgA Vasculitis with Nephritis clinical trials depends on factors like age, diagnosis, treatment history, and overall health. Each trial sets its own inclusion and exclusion criteria. Trial Friend translates these requirements from medical language into plain English so patients can review them more easily. The Match Me tool can score your profile against active trials to help identify studies that may be a fit.

Participating in a IgA Vasculitis with Nephritis clinical trial typically involves scheduled visits, medical tests, and close monitoring by a research team. Depending on the study phase, you may receive an investigational treatment, a placebo, or the current standard of care. Trials may last from a few weeks to several years. Study participation is voluntary, and you can withdraw at any time.