Also on Trial Friend:Leigh Syndrome pageMatch Me
All 5 Leigh Syndrome trials and their US sites
Enter your ZIP code above to sort them by how far their nearest open site is from you.
- Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at SanfordOnly in South DakotaRecruitingSanford Health1US site
- The International Registry for Leigh SyndromeOnly in TexasRecruitingAges 0 Days-100The University of Texas Health Science Center, Houston1US site
- The NIH MINI Study: Metabolism, Infection, and Immunity in Inborn Errors of MetabolismOnly in MarylandRecruitingAges 4 Weeks-115National Human Genome Research Institute (NHGRI)1US site
- Drug Repurposing for Mitochondrial Disorders Using iPSCs Derived Neural CellsRecruitingCharite University, Berlin, GermanyNo US site yet
- Global Registry and Natural History Study for Mitochondrial DisordersRecruitingLMU KlinikumNo US site yet
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Who runs the Leigh Syndrome trials in the US, and what stage they are in
None of the 3 Leigh Syndrome trials with a US site is in Phase 3, the last stage before a company can ask the FDA for approval. The remaining 3 have no drug phase, such as studies that follow people over time or test a device or a way of giving care. Universities, hospitals, foundations and government groups run all of them, with no company leading one. The most recently listed one first appeared on ClinicalTrials.gov on May 2, 2017.
Leigh Syndrome trials in the US, state by state
All 3 Leigh Syndrome trials with a US site accept children under 18. Their open sites are in Maryland, South Dakota and Texas. A trial counts once in each state where it has an open site, and some trials accept both children and adults.
US hospitals running the most Leigh Syndrome trials
Centers that run trials for a rare condition often see more people with it than most clinics do, so this list can also help you find doctors who know Leigh Syndrome.
- National Institutes of Health Clinical CenterBethesda, Maryland1 trial
- Sanford HealthSioux Falls, South Dakota1 trial
- The University of Texas Health Science Center at HoustonHouston, Texas1 trial
Help getting to a Leigh Syndrome trial far from home
Ask the study team whether the trial pays back travel, parking and hotel costs, because many sponsors do. The FDA's guidance on paying research volunteers says paying back these costs does not count as pressuring someone to join.
These nonprofits also help patients reach care, and each one sets its own rules.
- Mercy Medical Angels
- Pays for gas cards, ground rides and airline tickets anywhere in the US, and it lists clinical trials as a reason to travel. Household income at or below 300% of the federal poverty guidelines, and usually a trip of 50 miles or more each way.
- Air Charity Network
- Volunteer pilots in all 50 states fly patients for free in small private planes, and members also fly people taking part in clinical trials. You must be able to walk and sit upright for the flight, show financial need and have a backup plan if weather cancels it.
- Ronald McDonald House
- Gives families a room near the hospital while a child gets care, through 394 House programs around the world. Families of a sick child, with rules set by each local chapter.
- Healthcare Hospitality Network
- Keeps a map of hospitality houses near hospitals, and most member houses charge little or nothing to patients and families. Each house sets its own rules, so check with the house near your study site.
Program details were checked on each program's website on October 24, 2026.
Questions about finding a Leigh Syndrome trial near you
Are there Leigh Syndrome clinical trials near me?
As of November 13, 2026, 5 Leigh Syndrome clinical trials are recruiting now and 1 is not yet recruiting. In the US, 3 of them have at least 1 open site, across 3 states. Enter your ZIP code on this page to rank every one of them by the distance to its closest open site, with the sites shown on a map.
Which states have Leigh Syndrome clinical trial sites?
Recruiting Leigh Syndrome trials list open sites in Maryland, South Dakota and Texas.
Are there Leigh Syndrome trials for children near me?
All 3 Leigh Syndrome trials with a US site accept children under 18. Their open sites are in Maryland, South Dakota and Texas. Each trial sets its own age limits, so check the ages listed on a trial before you contact it.
Who pays for travel to a Leigh Syndrome clinical trial?
Many trial sponsors pay back travel, parking and hotel costs, so ask the study team before you rule out a far-away site. The FDA's guidance says paying back these costs does not count as pressuring someone to join. Charities such as Mercy Medical Angels and Air Charity Network can also help with rides and flights.
What if there is no Leigh Syndrome trial near me?
Some trials send staff to your home or use a local lab, so fewer visits happen at the study site. You can also sign up on this page to get an email when a Leigh Syndrome trial opens a new site or changes status.
How is the distance to a trial site measured?
Distances are straight-line miles from the center of your ZIP code to each study site's listed location, not driving distance. Your browser looks up the ZIP code's coordinates with a free map service, Zippopotam.us, and the ZIP code is never sent to or stored by Trial Friend.
Clinical trials near you for related conditions
Source: ClinicalTrials.gov, trials with status Recruiting or Not yet recruiting. Refreshed every 6 hours; counts as of November 13, 2026. Sites that ClinicalTrials.gov lists as closed or withdrawn are left out. Children means the trial's age group includes people under 18.