Suspect-and-test checklist
Idiopathic pulmonary fibrosis (IPF)
Progressive lung fibrosis of unknown cause, mostly after age 60. Exertional dyspnea, dry cough and velcro crackles at the bases call for HRCT.
ICD-10-CMJ84.112Trial Friend for Clinicians
1Red flags present
Symptoms and history
Examination
Imaging
Earlier care
Family and age
2Already labeled as
3Family to test
4Testing, in the order the sources describe
- Auscultation at the lung basesBilateral velcro crackles predicted fibrotic ILD on HRCT.Result
- HRCT chest, noncontrast, volumetricSections of 1.5mm or less; supine inspiratory and expiratory; prone optional.Result
- Radiology read: 1 of 4 patternsUIP, probable UIP, indeterminate for UIP, or alternative diagnosis.Result
- Medication and exposure historyHome, work and places visited often, including exposures linked to HP.Result
- Serologic testing for CTDRecommended by the 2018 guideline for newly detected ILD of unknown cause.Result
- Serum IgG to potential HP antigensSuggested by the 2020 HP guideline, very low confidence.Result
- Multidisciplinary discussionUIP or probable UIP in the right setting: IPF without biopsy.Result
- BAL, surgical biopsy or cryobiopsyFor indeterminate or alternative patterns. Cryobiopsy only at experienced centers.Result
- Family history; genetic testing where relevantTERT or TERC variants in about 15% of familial pulmonary fibrosis.Result
5Results the sources say do not rule it out
- Inhalers were tried. Only 33% on inhalers before IPF met asthma or COPD criteria.
- A pulmonologist already saw the patient. In Medicare data 34.7% of first visits came over 3 years before diagnosis.
- No honeycombing on CT. Probable UIP can still support IPF without biopsy.
- No exposure found. None is identified in up to 60% of HP patients.
- No clubbing. Measured prevalence in IPF ranged from 7% to 52%.
6Specialists the sources name
Diagnosis code: J84.112 Idiopathic pulmonary fibrosisCodes patients often carry before diagnosis are listed in the online guide.
Full guide and sourcesEvery point here is sourced in the online guide, which also has a patient note to print.
Trial Friend, trialfriend.com/for-clinicians. Key sources: ATS/ERS/JRS/ALAT 2018 guideline; ATS/ERS/JRS/ALAT 2022 update; ATS/JRS/ALAT 2020 HP guideline; Hoyer 2019 Danish delay study; INTENSITY survey (2018); Lamas 2011 delayed access study; all 22 with links in the online guide. Checked November 11, 2026. A reference checklist for licensed clinicians that summarizes published sources. It is not a diagnostic tool, a score or a protocol, and it does not replace clinical judgment, local practice or the prescribing information. Not coding advice. Trial Friend never receives anything written or typed on this sheet.