Starting Tryngolza (olezarsen)Your first 90 days with familial chylomicronemia syndrome (FCS): the steps, the dates and who to call

How you take it

One shot under the skin once a month, from an autoinjector pen kept in the refrigerator. You keep your low-fat diet, 20g of fat or less a day.

Before your first dose

• Your doctor sends the prescription to one of 4 pharmacies that supply Tryngolza. Some insurance plans pick the pharmacy.
• The pharmacy calls or texts you about your coverage and costs. Answering helps you avoid delays.
• Your insurance approves the medicine. Some plans want a triglyceride blood test from before treatment and proof of your FCS diagnosis.
• If you have insurance, the Quick Start program may send free medicine while your plan decides.
• Your doctor may check your liver with a blood test before you start.
• Someone shows you or your caregiver how to give the shot before your first dose.

The first 90 days

1. Before the first doseYour doctor sends the prescription to the pharmacy
2. After the prescriptionThe pharmacy calls or texts about coverage and costs
3. While the plan decidesInsurance approval, and free medicine while you wait if you are eligible
4. Once approvedYour first pen and a Welcome Kit are delivered
5. Day 1First dose
6. Before each monthly dose, then every 30 daysYour next pen is delivered
7. 1 month inIn the FCS study, the protein that slows the clearing of triglycerides was already lower at 1 month
8. 1 month after dose 1, then every 30 daysSecond dose, then once a month
9. 3 months inThree months in, and your doctor decides when your triglycerides are checked