Starting Redemplo (plozasiran)Your first 90 days with familial chylomicronemia syndrome (FCS): the steps, the dates and who to call

How you take it

One 25mg shot under the skin every 3 months, in the front of the thigh or the belly. You or a caregiver give it at home after a healthcare provider shows you how. The label says to keep to a low-fat diet of 20g of fat or less a day.

Before your first dose

• Your doctor fills out the Redemplo Start Form. It is the prescription, and it can also sign you up for Rely On Redemplo, the drugmaker's support program.
• You give your consent for the support program, on the form or later with a Care Coordinator. The program is not required to get the medicine.
• Your insurance approves the medicine. Plans such as Cigna ask for a triglyceride blood test result and proof that you have FCS.
• If insurance is slow, you may be able to get a dose at no cost through Quick Start, if you are eligible. Your doctor checks a box on the form.
• One specialty pharmacy, Vanscoy Rare Specialty Pharmacy, sends the medicine. A Starter Kit can come to your home with the first dose.
• Your healthcare provider shows you or your caregiver how to give the shot before the first dose.

The first 90 days

1. About 2 weeks beforeYour doctor sends the Start Form
2. After the formInsurance review and approval
3. If approval stallsA no-cost dose may be possible if insurance is slow
4. Days beforeThe carton and the Starter Kit
5. Day 1Dose 1, one 25mg injection
6. OngoingThe low-fat diet continues
7. Days afterThe injection site
8. About 1 monthAbout 1 month in
9. Week before dose 2Next carton, with 1 syringe inside
10. By 3 monthsBy 3 months, what the trial saw on blood tests
11. 3 months after dose 1, then every 91 daysSecond shot, 3 months after the first, then every 3 months