Starting Lynavoy (linerixibat)Your first 90 days with primary biliary cholangitis (PBC): the steps, the dates and who to call

How you take it

One 40mg tablet morning and evening, swallowed whole with water, at least 30 minutes before any food or drink except water.

Before your first dose

• Blood tests of your liver, your vitamin A, D and E levels, and how well your blood clots.
• A check by your doctor that your liver disease is not too advanced for Lynavoy.
• A full medicine check. Bile acid binding resins, such as cholestyramine or colesevelam, are taken at least 4 hours apart from Lynavoy.
• Your doctor fills out the Interconnect enrollment forms, and you sign them.
• Your insurance approves the medicine. Plans such as Cigna want to see moderate to severe itch and one other itch medicine already tried.
• PANTHERx Rare, the only specialty pharmacy for Lynavoy, ships it to your home or your place of work.

The first 90 days

1. 2 weeks beforeBlood tests before your first dose
2. Week beforeYou sign the forms, then a Care Manager calls
3. Day 1First dose, 40mg morning and evening
4. Day 14Two weeks in
5. Day 20Most diarrhea in the trial began in the first 20 days
6. Week 4Order your refill about a week before you run out
7. Day 31, then every 30 daysRefill, then about every 30 days
8. Day 90Three months in
9. Month 5Your insurance approval may need renewing around month 6