Starting Besremi (ropeginterferon alfa-2b-njft)Your first 90 days with polycythemia vera: the steps, the dates and who to call

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Fill in with your doctor's office

First dose date

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Specialty pharmacy name

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The Medication Guide says to stop using Besremi and get medical help right away for:

Thoughts of hurting yourself or of suicide, or signs of a serious allergic reaction, which are skin rash or hives, itching, swelling of your face, eyes, lips, tongue or throat, trouble breathing, chest pain, or feeling dizzy or faint.

Also tell your doctor's office about:

Right away, mood or behavior changes: thoughts about suicide or dying, suicide attempts, new or worse depression, anxiety or irritability, panic attacks, feeling very agitated or restless, trouble sleeping, acting aggressive, angry or violent, acting on dangerous impulses, an extreme increase in activity or talking, or other unusual changes
Right away, heart or clot signs: fast or abnormal heartbeat, trouble breathing or chest pain, pain, swelling or redness in the arms, legs, ankles or feet, tiredness, sudden confusion, numbness or weakness, loss of coordination, trouble speaking clearly, or sudden vision changes
Right away, bleeding or infection signs: weakness and tiredness, bruising easily, frequent nosebleeds, gum or tongue bleeding, bleeding in the eye, fever, chills, burning and painful urination, urinating often, or coughing up yellow or pink mucus
Right away, thyroid or blood sugar signs: tiredness, urinating more often than normal, being very thirsty, increased appetite, problems concentrating, sensitivity to heat or cold, weight changes, or skin changes
Pancreas or bowel signs: nausea, vomiting, pain in the stomach area, bloating, fever, bloody diarrhea, or blood in your stool
Lung or eye signs: shortness of breath, cough, difficulty breathing, blurred vision, dry eyes, floaters or flashes of light, sudden loss of vision, or eye pain or redness
Liver or kidney signs: yellowing of the skin or the whites of the eyes, swelling, pain or discomfort in the stomach area, confusion, sleepiness, nausea, loss of appetite, tiredness, diarrhea, bleeding more easily than normal, changes in the amount or color of urine, blood in the urine, or swollen ankles
Skin problems, where the Medication Guide says to get medical help: itching, hair loss, rash, redness, dry skin, red scaly patches, acne, thickening of the skin, or excessive sweating
Dizziness, sleepiness or hallucinations, and avoid driving or heavy machinery if you have them
An injection of too much Besremi, right away, or a pregnancy during treatment

PharmaEssentia SOURCE800-700-5053

Monday through Friday, 8:00 AM to 8:00 PM Eastern

The drugmaker's support program, for questions about getting the medicine and paying for it. Answer calls from the specialty pharmacy; a missed call can delay your delivery.

Scan for your full plan, with every date added to your phone calendartrialfriend.com/p/besremi

How you take it

One shot under the skin every 2 weeks, in the lower belly or the top of the thigh. Each syringe or pen holds more than most doses, so you set your dose first and throw the rest away.

Before your first dose

A check that Besremi is safe for you. The label says some people must not use it, such as people who have had severe depression or thoughts of suicide.
Blood tests of your blood counts, liver, kidneys and blood fats, so there is a starting point to compare with later.
A pregnancy test, if you could become pregnant, and a plan for birth control that lasts until at least 8 weeks after the last dose.
An eye exam, which the label advises before and during treatment, especially if you have diabetes or high blood pressure.
A full list of your medicines, vitamins and herbal supplements for your blood doctor and pharmacist.
A lesson on storing, setting up and giving the shot before you give one yourself.
You call PharmaEssentia SOURCE, the drugmaker's support program, at 800-700-5053, or your doctor faxes its form. SOURCE checks your insurance and may help with costs.
A specialty pharmacy ships the medicine to your home. Keep it in the refrigerator, in its box, and never freeze it.

The first 90 days

Weeks beforeSign up with the support program, insurance check
Before day 1Blood tests, and a pregnancy test if it applies
Before day 1Eye exam
Week beforeLesson on giving the shot
Days beforeWelcome Kit
Day 1First injection
Day 15, then every 14 daysBlood count, and your dose may go up
Weeks 3 to 12Blood count, and your dose may go up
About 1 monthAsk the pharmacy when your next box ships
Week 13Hydroxyurea ends by now, if you were coming off it
About 3 monthsStill early by the study's measure

Trial Friend, trialfriend.com. From the Besremi FDA label dated August 25, 2026 and the drugmaker's program, checked November 12, 2026. Not medical advice: Trial Friend is not a medical provider, and your doctor decides your dose and tests.