Starting Vyndamax (tafamidis)Your first 90 days with ATTR amyloidosis with cardiomyopathy: the steps, the dates and who to call

How you take it

One capsule once a day, swallowed whole, not crushed or cut. The label found food makes no meaningful difference.

Before your first dose

• Proof of your diagnosis for your insurance: a heart scan, a tissue sample (biopsy) or a genetic test, plus a heart ultrasound or MRI showing the heart is affected.
• If you took Vyndaqel, the 4-capsule form, you will likely need a new prescription for Vyndamax. The doses are not swapped by milligrams, and your insurance will likely want a new approval.
• If you take Attruby or a gene-silencing drug, your heart doctor decides the plan. Some insurers will not pay for both.
• A medicine check. Vyndamax can raise levels of a few medicines, such as rosuvastatin and methotrexate.
• Your insurance approves the medicine. VynAssist, the drugmaker's support program, can explain your coverage and costs.
• A specialty pharmacy calls you and mails the capsules to your home.

The first 90 days

1. 2 weeks beforeDiagnosis records sent to your insurance
2. Days beforeThe specialty pharmacy calls
3. Day 1First dose, one 61mg capsule
4. Day 31, then every 30 daysRefill, then about every 30 days
5. Day 90Three months in
6. Before 1 yearYour insurance approval comes up for renewal