Starting Strensiq (asfotase alfa)Your first 90 days with hypophosphatasia (HPP): the steps, the dates and who to call

Trial Friendtrialfriend.com

Fill in with your doctor's office

First dose date

Doctor who prescribed it

Doctor's office phone

Specialty pharmacy name

Specialty pharmacy phone

The Patient Information says to go to the nearest hospital emergency room right away for:

Trouble breathing, a choking feeling, swelling of the eyes, lips or tongue, dizziness, nausea or vomiting, fever, sweating, chills, rash or hives, or itching or numbness of the mouth, during or after a shot, even after more than a year of treatment.

Also tell your doctor's office about:

HPP symptoms that get worse, such as harder breathing or walking, tiredness, bone pain, stiff joints or loss of appetite
New broken bones, or needing more breathing support
Redness, swelling, pain, lumps, dents or color changes where the shots go
Changes in vision, or new problems with the kidneys
A change in weight, since the dose is based on it
A pregnancy, plans for one, or breastfeeding

Alexion OneSource1-888-765-4747

Monday to Friday, 8:30am to 8pm ET

The drugmaker's support program, for questions about getting the medicine and paying for it. Answer calls from the specialty pharmacy; a missed call can delay your delivery.

Scan for your full plan, with every date added to your phone calendartrialfriend.com/p/strensiq

How you take it

A small shot under the skin, 3 or 6 times a week. The dose is based on weight. A parent, guardian, caregiver or the patient gives it, following the Instructions for Use that come with it. The first shot is given with a healthcare provider.

Before your first dose

Blood tests that show HPP, and a note of when the first signs began.
A recent weight, because every dose is worked out from it.
An eye exam and a kidney ultrasound. HPP can leave calcium in the eyes and kidneys, so doctors check before and during treatment.
Your doctor's office sends the prescription to PANTHERx Rare, the pharmacy that ships Strensiq. You sign a separate form for OneSource, the drugmaker's support program, at 1-888-765-4747.
Your insurance approves the medicine. PANTHERx Rare then ships cold vials, needles and syringes. The vials go straight into the refrigerator.

The first 90 days

Weeks beforePrescription form and OneSource enrollment
Before treatmentEye exam and kidney ultrasound before the first shot
Days beforeInsurance approval, then the pharmacy schedules shipping
Days beforeThe cold shipment arrives
Day 1First shot, with a healthcare provider watching
Day 3Next shot on the schedule
Day 8One week in
Day 29, then every 28 daysNew box every 28 days
About 3 monthsA new weight can change the dose

Trial Friend, trialfriend.com. From the Strensiq FDA label dated December 12, 2025 and the drugmaker's program, checked November 10, 2026. Not medical advice: Trial Friend is not a medical provider, and your doctor decides your dose and tests.