Starting Nexviazyme (avalglucosidase alfa-ngpt)Your first 90 days with pompe disease: the steps, the dates and who to call

Trial Friendtrialfriend.com

Fill in with your doctor's office

First dose date

Doctor who prescribed it

Doctor's office phone

Specialty pharmacy name

Specialty pharmacy phone

Get medical care right away, during an infusion or in the hours after it, for:

Chest discomfort; trouble breathing; a swollen tongue or swelling all over; hives, rash or redness; feeling faint from low blood pressure.

Also tell your doctor's office about:

Headache, chills, fever, itching or nausea during or after an infusion
Any reaction at a past infusion, before the next one
Feeling sick with a new illness before an infusion day
A change in weight, since the dose is set by weight
A pregnancy or breastfeeding, to your doctor

CareConnectPSS (CareConnect Personalized Support Services)1-800-745-4447, option 3

Monday to Friday, 8 AM to 6 PM Eastern

The drugmaker's support program, for questions about getting the medicine and paying for it. Answer calls from the specialty pharmacy; a missed call can delay your delivery.

Scan for your full plan, with every date added to your phone calendartrialfriend.com/p/nexviazyme

How you take it

An infusion into a vein every 2 weeks that takes about 4 to 7 hours. The dose is set by your weight.

Before your first dose

A lab test or a genetic test that confirms late-onset Pompe disease. Your insurance may ask for the report.
Your current weight, because it sets the dose and the size of the bag. Tell the doctor's office if your weight changes.
Your insurance approves the medicine. CareConnectPSS, the drugmaker's support program, can help. Call 1-800-745-4447 and press 3.
If you have insurance through work or a private plan, ask about QuickStart. It may let you start for free while the plan decides.
The first infusion is booked at a place that is ready to treat a serious allergic reaction.
You may get allergy, fever or steroid medicine before each infusion. Plan for a long day, since infusions run for hours.

The first 90 days

Before the first infusionSign up with the support program, insurance check
Once approved, or on QuickStartApproval, then booking the first infusion
Day 1Day 1: first infusion, starting slow and speeding up
Day 15Infusion 2
Day 29Infusion 3
Day 43Fourth infusion, and refill reminders from Sanofi
Day 57Infusion 5
Day 71Infusion 6
Day 85Infusion 7

Trial Friend, trialfriend.com. From the Nexviazyme FDA label dated June 5, 2025 and the drugmaker's program, checked November 10, 2026. Not medical advice: Trial Friend is not a medical provider, and your doctor decides your dose and tests.