Starting Mimrylo (rusfertide)Your first 90 days with polycythemia vera: the steps, the dates and who to call

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Fill in with your doctor's office

First dose date

Doctor who prescribed it

Doctor's office phone

Specialty pharmacy name

Specialty pharmacy phone

The label says to contact your healthcare provider for:

Unusual bruising or bleeding, chest pain, shortness of breath, leg pain or swelling, or a sudden severe headache, which can be signs of bleeding or a blood clot.

Also tell your doctor's office about:

An injection site reaction that is severe or does not go away
A pregnancy, or any chance of one, right away
A missed dose, if you are not sure when to inject it
Any new medicine, vitamin or herbal supplement

Takeda Oncology Here2Assist (MIMRYLO Patient Support)1-844-817-6468

Option 2, Monday to Friday, 8 AM to 8 PM Eastern

The drugmaker's support program, for questions about getting the medicine and paying for it. Answer calls from the specialty pharmacy; a missed call can delay your delivery.

Scan for your full plan, with every date added to your phone calendartrialfriend.com/p/mimrylo

How you take it

One shot under the skin once a week, given at home by you or a helper after training. You mix a powder with liquid first and give the shot within 4 hours.

Before your first dose

A pregnancy test, if you could become pregnant, and a plan for birth control that lasts until at least 30 days after the last dose.
A lesson on mixing and giving the shot before your first dose. Takeda's support program offers a free nurse, by video or in person.
A full list of your medicines, vitamins and herbal supplements for your blood doctor and pharmacist.
Your blood doctor's office sends a form to Takeda Oncology Here2Assist, the drugmaker's support program. You sign it too, with a real signature.
Your insurance approves the medicine. Here2Assist checks what your plan covers and may help with costs.
A specialty pharmacy ships the medicine to your home, or your doctor's office may hand it to you.

The first 90 days

Weeks beforeSign up with the support program, insurance check
Before day 1Pregnancy test, where it applies
Week beforeLesson on mixing and giving the shot
Days beforeThe first carton ships
Day 1First injection, 19mg
Day 15Blood count, and your dose may go up
Week 4Ask the pharmacy when your next box ships
Day 29Platelets at about 4 weeks
Week 9Your platelet count usually settles by now
About 3 monthsStill early by the study's measure

Trial Friend, trialfriend.com. From the Mimrylo FDA label dated August 28, 2026 and the drugmaker's program, checked November 9, 2026. Not medical advice: Trial Friend is not a medical provider, and your doctor decides your dose and tests.