Starting Dawnzera (donidalorsen)Your first 90 days with hereditary angioedema (HAE): the steps, the dates and who to call

How you take it

One shot under the skin every 4 weeks, from an autoinjector pen kept in the refrigerator. The label says every 8 weeks may also be considered, and your doctor decides.

Before your first dose

• Your doctor fills in an enrollment form for Ionis Every Step, the drugmaker's support program. You sign it too, in the office, online or by phone.
• You get a Welcome Kit with a practice pen, and a call to set up injection training.
• Your insurance approves the medicine. Some plans want blood test results that confirm your type of HAE.
• If you have insurance, the Quick Start program may send free medicine while your plan decides.
• The specialty pharmacy calls from 1-844-444-4305. The medicine does not ship until you have talked with them.

The first 90 days

1. Before the first doseEnrollment form sent, then the insurance check
2. After you sign upA Welcome Kit and a call from Ionis Every Step
3. Once approvedThe pharmacy calls to set up delivery
4. Day 1First dose
5. Before day 29, then every 28 daysYour next pen is delivered
6. Week 4In the main study, the protein behind HAE swelling was already lower at week 4
7. Day 29, then every 28 daysSecond dose, then every 4 weeks
8. Day 57Second dose on the every-8-week schedule
9. Day 90Three months in