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How you take it

One shot under the skin every 3 months, given by a nurse or doctor at an office, a treatment center or your home. The label also advises a daily vitamin A supplement at the recommended amount, and no more.

Before your first dose

• You and your heart doctor sign a Start Form for Alnylam Assist, the drugmaker's support program. The form also works as your prescription.
• An Alnylam Case Manager calls you within 2 business days to explain what your insurance covers.
• Your insurance approves the medicine. If it says no, or has not answered after 7 days, a new patient may get one dose free.
• You and your doctor pick where you get the shot. That can be the office, a treatment center, or your home if your insurance pays for it.
• Ask your heart doctor which vitamin A supplement to take, how much, and when to start. The label says not to take more than the recommended amount.

The first 90 days

1. 3 weeks beforeStart Form signed and sent
2. 2 business daysA Case Manager calls
3. About 2 weeks beforeInsurance approval, and a free dose if it is slow
4. Week beforeWhere the shot is given
5. Day 1Dose 1, one 25mg injection
6. OngoingDaily vitamin A, at the recommended amount
7. Days afterThe injection site
8. Week before dose 2A reminder or check-in before your second shot
9. 3 months after dose 1, then every 91 daysSecond shot, 3 months after the first, then every 3 months